A5101733925- Probiotics and Fermented Foods
- Gut microbiota and health
- Microbial Metabolites in Food Biotechnology
- Multiple Sclerosis Research Studies
- Helicobacter pylori-related gastroenterology studies
- Infant Nutrition and Health
- Dermatology and Skin Diseases
- Skin Protection and Aging
- Peripheral Neuropathies and Disorders
- Extracellular vesicles in disease
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Antimicrobial Peptides and Activities
- RNA Interference and Gene Delivery
- Digestive system and related health
- Animal health and immunology
- Diet and metabolism studies
- Bee Products Chemical Analysis
- Cardiac Imaging and Diagnostics
- melanin and skin pigmentation
- Asthma and respiratory diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Boron Compounds in Chemistry
- Psoriasis: Treatment and Pathogenesis
- Autoimmune Neurological Disorders and Treatments
Institute of Livestock and Grassland Science
2009-2025
National Agriculture and Food Research Organization
2012-2025
Chiba University
2020-2023
Kanazawa University Hospital
2023
Osaka Prefecture University
2017-2022
Japan Women's University
2019-2021
Tonami General Hospital
2021
The University of Tokyo
2013-2019
Chiba Rosai Hospital
2017-2018
Hokkaido University
2009-2016
ABSTRACT Although hibernating mammals wake occasionally to eat during torpor, this period represents a state of fasting. Fasting is known alter the gut microbiota in nonhibernating mammals; therefore, hibernation may also affect microbiota. However, there are few reports mammals. The present study aimed compare torpid Syrian hamsters with that active counterparts by using culture-independent analyses. Hamsters were allocated either torpid, fed active, or fasted groups. Hibernation was...
Because gut microbiota has recently attracted much attention as an environmental factor involved in the development of obesity, probiotics may be useful preventing and/or improving obesity and its related disorders. The present study aimed to investigate effects Lactobacillus plantarum strain No. 14 (LP14), a bacterial reported decrease body fat percentage healthy volunteers, on adipocyte size mice. Female C57BL/6 mice were fed either normal- or high-fat diet administered intragastrically...
Extracellular vesicles (EVs) including exosomes have been shown to play crucial roles in cell-to-cell communication because of their ability carry biofunctional molecules (e.g., microRNAs and enzymes). EVs also pharmaceutical advantages are highly anticipated be a next-generation intracellular delivery tool. Here, we demonstrate an experimental technique that uses arginine-rich cell-penetrating peptide (CPP)-modified induce active macropinocytosis for effective cellular EV uptake....
Abstract Aryl hydrocarbon receptor (AHR) agonists are promising immunomodulators that potentially maintain immune tolerance. In this study, we examined the ability of indole-3-pyruvic acid (IPA), a major precursor microbiota-derived AHR and proagonist AHR, to activate AHR. The anti-inflammatory effects IPA were also evaluated in mouse model colitis comparison with other aromatic pyruvic acids (phenylpyruvic 4-hydroxyphenylpyruvic acid). Among them, showed strongest vitro vivo, only improved...
This study examined the role of degree polymerization (DP) inulin-fructans in modulating interaction between lactic acid bacteria and IgA cecal secretion. Rats were fed a control diet or containing one fructans with different DP. Consuming increased concentrations order DP4 > DP8 DP16. Cecal lactobacilli counts higher DP4, DP8, DP16, whereas bifidobacteria DP23. correlated (P < 0.01). but not DP23, significantly IgA-producing plasma cells mucosa. IFN-γ IL-10 production CD4+ T was enhanced...
The microbiota–gut–brain axis plays an important role in the development of stress-induced mental disorders. We previously established subchronic and mild social defeat stress (sCSDS) model, a murine experimental model depression, investigated metabolomic profiles plasma liver. Here we used omics approaches to identify changes gastrointestinal tract. Mice exposed sCSDS for 10 days showed following changes: (1) elevation cholic acid reduction 5-aminovaleric among cecal metabolites; (2)...
Strategies to manipulate the gut microbiota in infancy have been considered prevent development of allergic diseases later life. We aimed elucidate effects maternal dietary supplementation with a prebiotic oligosaccharide on and spontaneously developing atopic dermatitis-like skin lesions offspring NC/Nga mice. Female mice were fed diets either or without fructo-oligosaccharide during pregnancy lactation. After weaning, supplemented for 11 weeks an air-uncontrolled conventional room. Changes...
Boron neutron capture therapy (BNCT) is a radiation for cancer. In BNCT, the internalization of boron-10 atoms by cancer cells induces cell death through generation α particles and recoiling lithium-7 nuclei when irradiated with low-energy thermal neutrons. this study, we aimed to construct exosomes [extracellular vesicles (EVs)]-based drug delivery technology in BNCT. Because their pharmaceutical advantages, such as controlled immune responses effective usage cell-to-cell communication, EVs...
Boron neutron capture therapy (BNCT), a type of nuclear capture-based radiotherapy, has received extensive attention because its strong anticancer effects, especially in head and neck cancers. This was approved for clinical use 2020 Japan. study demonstrated technique that effectively uses the electrostatic interactions negatively charged borane cage (polyhedral anion) disodium mercaptoundecahydro-closo-dodecaborate (BSH) positively cationic lipids or arginine-rich cell-penetrating peptides...
Elimination of transient pulmonary vein recurrences (dormant PVs) induced by an ATP injection and ablation at the PV carina region is effective strategy for atrial fibrillation (AF) ablation. The relationship between dormant PVs has not been evaluated.A total 212 consecutive symptomatic AF patients underwent circumferential electrical isolation (CPVEI) with a double lasso technique. They were divided into 2 groups in retrospective review; Group 1: those given during intravenous isoproterenol...
To investigate longitudinal brain atrophy in patients with neuromyelitis optica spectrum disorder (NMOSD).We investigated the rate aquaporin-4 antibody-positive NMOSD (AQP4+NMOSD) and those multiple sclerosis (MS) a retrospective cohort study. Brain volume was calculated statistical parametric mapping-12.We enrolled 36 AQP4+NMOSD 60 MS. Patients were older had higher Kurtzke's expanded disability status scale score at baseline MRI compared Disease duration, annual relapse intervals from last...
Abstract We conducted a double-blind, placebo-controlled trial to evaluate the effect of heat-killed cells Lactococcus lactis strain H61 on various skin properties Japanese women. Volunteers (age 31–62 years) were randomly assigned receive test food with or without 60 mg (fifteen women in each group; and control groups, respectively) daily for 8 weeks. Results analysed three age categories (30s, 40s 50–60s). Compared that at week 0, hydration inner forearm weeks 4 decreased all volunteers...
Excess accumulation of white adipose tissue can lead to obesity-related metabolic abnormalities such as insulin resistance. We previously reported that intragastric administration Lactobacillus plantarum No. 14 reduced adipocyte size in diet-induced obese C57BL/6 mice. The present study tested whether L. affects adiposity and sensitivity an animal model type-2 diabetes mellitus. Male KK/Ta mice were fed a normal-fat diet intragastrically given (10(8) CFU/mouse) or vehicle daily for 10 weeks....
Lactoferrin exerts its biological activities by interacting with receptors on target cells, including LDL receptor-related protein-1 (LRP-1/CD91), intelectin-1 (omentin-1), and Toll-like receptor 4 (TLR4). However, the effects mediated these are not sufficient to fully explain many functions of lactoferrin. C-X-C-motif cytokine (CXCR4) is a ubiquitously expressed G-protein coupled for stromal cell-derived factor-1 (SDF-1/CXCL12). was found be as capable SDF-1 in blocking infection an HIV...
Boron neutron capture therapy (BNCT) is a radiation method used for cancer therapy. Cellular uptake of boron-10 (10B) atoms induces cell death by the generation alpha particles and recoiling lithium-7 (7Li) nuclei when cells are irradiated with low-energy thermal neutrons. Current BNCT technology shows effective therapeutic benefits in refractory cancers such as brain tumors head neck cancers. However, improvements to targeting cellular efficacy boron compounds expansion diseases treatable...
Transesophageal echocardiography (TEE) is useful for detecting left atrial (LA) thrombus prior to percutaneous LA catheter ablation in patients with fibrillation (AF). This study was designed evaluate clinical predictors of and determine indications TEE screening ablation.The consisted 446 drug-resistant AF who were scheduled undergo initial (age 59+/-11 years, 312 males, 136 persistent AF). performed all cases within 24 h before ablation. We assessed parameters including CHADS(2) score...
Probiotics such as lactic acid bacteria directly influence the host's health and have beneficial effects decreasing number of enteric pathogens, regulating intestinal immune responses preventing diseases. Among domestic animals, probiotics been expected to be an alternative antibiotics added in diet; fermented liquid diet (FLD) containing has great potential a for reducing use antibiotics. In this study, we evaluated immunomodulatory FLD, prepared using Lactobacillus plantarum LQ80 (LQ80),...
Administration of Lactobacillus rhamnosus GG (LGG) has been reported to be therapeutically effective against acute secretory diarrhoea resulting from the structural and functional intestinal mucosal lesions induced by rotavirus infection; however, underlying mechanisms remain completely elucidated. Because Toll-like receptor 3 (TLR3) plays a key role in innate immune responses following recognition rotavirus, present study examined whether LGG influences TLR3 gene expression murine small...
Food allergy is a serious problem for infants and young children. Induction of antigen-specific oral tolerance one therapeutic strategy. Enhancement induction by diet promising strategy to prevent food in infants. Thus, this study, we evaluate the effect probiotic Lactobacillus gasseri OLL2809 (LG2809) on mouse model. The degree was evaluated measuring proliferation level IL-2 production splenic CD4+ T cells from DO11.10 mice fed ovalbumin (OVA) alone or OVA with LG2809. Oral administration...