A5041703058- Maternal and fetal healthcare
- Kawasaki Disease and Coronary Complications
- Congenital Heart Disease Studies
- Coronary Artery Anomalies
- Artificial Intelligence in Healthcare and Education
- Cardiovascular Function and Risk Factors
- Cardiac Structural Anomalies and Repair
- Pregnancy and preeclampsia studies
- Ectopic Pregnancy Diagnosis and Management
- Maternal and Perinatal Health Interventions
- Congenital Diaphragmatic Hernia Studies
- Tracheal and airway disorders
- Lung Cancer Research Studies
- Mechanical Circulatory Support Devices
- Cardiovascular Issues in Pregnancy
- Neurological Complications and Syndromes
- Academic Writing and Publishing
- Neuroblastoma Research and Treatments
- Cardiac Valve Diseases and Treatments
- Vasculitis and related conditions
- Uterine Myomas and Treatments
- Cardiovascular and exercise physiology
- Meta-analysis and systematic reviews
- Acute Myeloid Leukemia Research
- Neuroendocrine Tumor Research Advances
Jichi Medical University
2016-2025
University of Tsukuba
2021-2025
Jichi Medical University Hospital
2018-2025
Children's Hospital of Philadelphia
2020-2024
John Wiley & Sons (Germany)
2024
International University of Health and Welfare
2023-2024
RELX Group (Netherlands)
2024
University of Pennsylvania
2020-2023
Philadelphia University
2020-2023
Weatherford College
2021
Abstract Aim To determine whether ChatGPT generates a manuscript with “human touch” appropriate inputs, and if yes, what's the difference between human writing versus writing. This is because presence or absence of touch may characterize Methods A descriptive study. The first author wrote Disagreement Letter (Letter 1). Then, disagreement points were provided as input into ChatGPT‐4 tasked generating 2). authors, seven experienced researchers, evaluated readability Letters 1 2. Results...
Background In multisystem inflammatory syndrome in children, there is paucity of longitudinal data on cardiac outcomes. We analyzed outcomes 3 to 4 months after initial presentation using echocardiography and magnetic resonance imaging. Methods Results included 60 controls cases children. Conventional echocardiograms deformation parameters were at time points: (1) acute phase (n=60), (2) subacute (n=50; median, days echocardiography), (3) 1‐month follow‐up (n=39; 22 days), (4) 3‐ 4‐month...
A manuscript written not adhering to the fundamentals of academic writing (so-called paper-writing rules) may be rejected before significance study is recognized. Submitting authors, especially those with little experience, neglect such fundamentals. simple checklist, which would enable authors check whether a for submission adheres fundamentals, should appear at beginning Author Guidelines medical journal. This checklist contribute following writing, thereby preventing rejection based...
Recent genetic analysis has identified frequent mutations in ten-eleven translocation 2 (TET2), DNA methyltransferase 3A (DNMT3A), isocitrate dehydrogenase (IDH2) and ras homolog family member A (RHOA) nodal T-cell lymphomas, including angioimmunoblastic lymphoma peripheral lymphoma, not otherwise specified. We examined the distribution of these subtypes mature T-/natural killer cell neoplasms to determine their clonal architecture. Targeted sequencing was performed for 71 genes...
Immune cells harboring somatic mutations reportedly infiltrate cancer tissues in patients with solid cancers and accompanying clonal hematopoiesis. Loss-of-function TET2 are frequently observed hematopoiesis cancers. Here, using a mouse lung model, we evaluated the activity of Tet2-deficient immune tumor tissues. Myeloid-specific Tet2 deficiency enhanced growth mice relative to that seen controls. Single-cell sequencing analysis infiltrating tumors showed relatively high expression...
ABSTRACT Introduction Secondary extramammary Paget's disease features intraepidermal carcinoma caused by tumor invasion and migration into adjacent skin. Case Presentation A 68‐year‐old man underwent radical cystectomy bilateral cutaneous ureterostomy for bladder cancer right ureteral cancer. Postoperative follow‐up computed tomography urine cytology at 3 years suggested recurrence. Contemporaneous erythema bulging of the skin around ureterocutaneous fistula were observed, necessitating...
Abstract Pulmonary high-grade neuroendocrine carcinomas (HGNECs), including small cell (SCLCs) and large (LCNECs), are highly aggressive have a poor prognosis. The molecular subtyping of HGNECs has recently attracted attention, Wang et al. proposed cross-tissue classification framework NECs, the hepatocellular nuclear factor 4 alpha (HNF4A) subtype [Cancer Cell, 2024]. HNF4α, transcription associated with gastrointestinal differentiation, TTF-1 mutually exclusively expressed in lung...
Background Cardiac dysfunction is a prominent feature of multisystem inflammatory syndrome in children (MIS-C), yet the etiology poorly understood. We determined whether global or regional, and it associated with cytokine milieu, microangiopathy, severity shock. Methods Results analyzed echocardiographic parameters myocardial deformation compared segmental left ventricular strain between 43 cases MIS-C ≤18 years old 40 controls. Primary outcomes included longitudinal strain, right free wall...
Atypical polypoid adenomyoma (APA) is a lesion that comprised of atypical endometrial glands and fibromuscular stroma, which pathologists often confuse with myoinvasive endometrioid carcinoma. Here, we characterized the immunohistochemical molecular features stromal components APA to find distinct markers between First, examined expression gene mutations were previously investigated in uterine breast fibroepithelial lesions using 12 cases APA. α-smooth muscle actin was diffusely positive...
Background Detection of coronary artery lesions (CALs) at initial echocardiography can aid in diagnosing Kawasaki disease (KD) and inform primary adjunctive treatments. We aimed to characterize patients with KD CALs detected echocardiography. Methods Results analyzed data from the nationwide Japanese survey that contained information on 103 222 population-based diagnosed across Japan during 2011 2018. Patients were assessed by age, day illness, number principal signs (≥3). Multivariable...
OBJECTIVE: Adenosquamous carcinoma originating in the stomach is an unusual neoplasm with few existing histological studies. This study was aimed to gain insight into histogenetic and clinicopathological characteristics of gastric cancer squamous cell (SCC) components. METHODS: From January 2001 June 2010 a total 1735 patients underwent resection cancer. Histopathologically, eight had adenocarcinoma containing SCC components, which proportion components above 25% tumor mass four patients....
We hypothesized left atrial (LA) stiffness may serve as a surrogate marker in children to differentiate elevated pulmonary capillary wedge pressure (PCWP) from normal and help detect diastolic dysfunction myocardial injury due multisystem inflammatory syndrome (MIS-C).We validated LA 76 patients (median age 10.5 years), 33 had PCWP (<12 mmHg) 43 (≥12 mmHg). was applied 42 MIS-C [28 with (+) 14 without (-)], defined by serum biomarkers. The validation group consisted of cardiomyopathies,...