A5046936386- Maternal and fetal healthcare
- Pregnancy and preeclampsia studies
- Maternal and Perinatal Health Interventions
- Ectopic Pregnancy Diagnosis and Management
- Uterine Myomas and Treatments
- Cardiovascular Issues in Pregnancy
- Birth, Development, and Health
- Pregnancy-related medical research
- Preterm Birth and Chorioamnionitis
- Artificial Intelligence in Healthcare and Education
- Reproductive System and Pregnancy
- Assisted Reproductive Technology and Twin Pregnancy
- Asthma and respiratory diseases
- Neonatal Respiratory Health Research
- Prenatal Screening and Diagnostics
- Gestational Trophoblastic Disease Studies
- Gestational Diabetes Research and Management
- Urban and spatial planning
- Neonatal Health and Biochemistry
- Neurological Complications and Syndromes
- Blood Coagulation and Thrombosis Mechanisms
- Allergic Rhinitis and Sensitization
- Pelvic floor disorders treatments
- Endometriosis Research and Treatment
- Vascular Procedures and Complications
Jichi Medical University
2016-2025
Koga Hospital
2021-2025
Tokyo Medical University Ibaraki Medical Center
2023-2025
Osaka University
2012-2024
Jichi Medical University Hospital
2013-2024
Otsuka (Japan)
2024
Nagoya University
2023
Jichi Medical University Saitama Medical Center
2022
Otemae University
2021
Obayashi (Japan)
2020
In this study, we performed small RNA library sequencing using human placental tissues to identify placenta-specific miRNAs. We also tested the hypothesis that chorionic villi could secrete miRNAs extracellularly via exosomes, which in turn enter into maternal circulation. By sequencing, most (e.g., MIR517A) were linked a miRNA cluster on chromosome 19. The genes differentially expressed development. Subsequent validation by real-time PCR and situ hybridization revealed villous trophoblasts...
Abstract The ‘ C linical G uidelines for O bstetrical P ractice, 2011 edition’ were revised and published as a 2014 edition (in J apanese) in A pril by the apan S ociety of bstetrics ynecology ssociation bstetricians ynecologists. aims this publication include determination current standard care practices pregnant women apan, widespread use practices, enhancement safety obstetrical practice, reduction burdens associated with medico‐legal medico‐economical problems, better understanding...
Abstract Aim ChatGPT's role in medical writing is a topic of discussion. I experimented whether ChatGPT almost automatically generates Correspondence or Letter addressed to “translated” article, and thereby wish arouse discussion regarding use writing. Methods input an English article mine into ChatGPT, tasking it with generating Disagreement (Letter 1). Next, tasked translating the manuscript from English‐French‐Spanish‐German. Then, once again German (triplicate translated manuscript) 2)....
Abstract Aim To determine whether ChatGPT generates a manuscript with “human touch” appropriate inputs, and if yes, what's the difference between human writing versus writing. This is because presence or absence of touch may characterize Methods A descriptive study. The first author wrote Disagreement Letter (Letter 1). Then, disagreement points were provided as input into ChatGPT‐4 tasked generating 2). authors, seven experienced researchers, evaluated readability Letters 1 2. Results...
Abstract Clinical guidelines for obstetrical practice were first published by the Japan Society of Obstetrics and Gynecology (JSOG) Association Obstetricians Gynecologists (JAOG) in 2008, a revised version was 2011. The aims this publication include determination current standard care practices pregnant women Japan, widespread use practices, enhancement safety practice, reduction burdens associated with medico‐legal medico‐economical problems, better understanding between maternity‐service...
In this study, to search for novel preeclampsia (PE) biomarkers, we focused on microRNA expression and function in the human placenta complicated with PE. By comprehensive analyses of expression, identified 22 microRNAs significantly upregulated preeclamptic placentas, 5 which were predicted silico commonly target mRNA encoding hydroxysteroid (17-β) dehydrogenase 1 (HSD17B1), a steroidogenetic enzyme expressed predominantly placenta. vivo HSD17B1 at both protein levels, was decreased...
For cesarean hysterectomy with placenta previa accreta, "universally achievable" measures are required. We propose eight measures: (i) placement of intra-iliac arterial occlusion balloon catheters; (ii) ureter stents; (iii) "holding the cervix" to identify site be transected; (iv) uterine fundal incision; (v) avoidance uterotonics; (vi) "M cross double ligation" for ligating ovarian ligament; (vii) "filling bladder" bladder separation and "opening accreta invasion; (viii) continue clamp...
High‑risk human papillomavirus (HPV) is a common cause of cervical cancer. HPV E6 oncoprotein promotes the degradation host tumor suppressor gene p53, leading to development tumors. Therapeutic strategies that specifically target E6, which constitutively expressed in tumors and not present normal tissues, may be highly effective safe. CRISPR‑CRISPR associated protein 9 (Cas9) one genome editing technologies has recently garnered attention, used knockout expression. By combining cancer cell...
Abstract Aim Artificial intelligence, especially ChatGPT, has been used in various aspects of medicine; however, whether ChatGPT can be case report writing is unknown. This study aimed to provoke discussion and provide a platform for it. Methods I wrote theoretical where cyst aspiration cured twisted ovarian (Manuscript 4). tasked with generating reports by inputting information at three different levels: (1) key message profile, (2) addition introduction (including known facts problems...
Abstract Recent studies in both human and rodents have indicated that addition to CD4+ T cells, CD8+ cells play an important role allergic inflammation. We previously demonstrated allergen-sensitized -challenged CD8-deficient (CD8−/−) mice develop significantly lower airway hyperresponsiveness (AHR), eosinophilic inflammation, IL-13 levels bronchoalveolar lavage fluid compared with wild-type mice, all these responses were restored by adoptive transfer of vivo-primed or vitro-generated...
During pregnancy, human placenta-associated microRNAs (miRNAs) derived from the miRNA cluster in chromosome 19 are expressed villous trophoblasts and secreted into maternal circulation via exosomes; however, little is known about whether circulating miRNAs transferred immune cells exosomes, modulate expression of target genes recipient cells. We employed an vitro model trophoblast-immune cell communication using BeWo (a trophoblast line) Jurkat leukemic T-cell investigated exosomal can...
Abstract Aim In placenta previa ( PP ), anterior placentation, compared with posterior is reported to more frequently cause massive hemorrhage during cesarean section CS ). Whether this due the high incidence of accreta, previous , or a transplacental approach in unclear. We attempted clarify issue. Material and Methods retrospectively analyzed relation between bleeding amount for various factors that may (>2400 m L ) n = 205) tertiary center. If preoperatively ultrasound‐measured...
Rationale: Leukotriene B4 (LTB4) is a rapidly synthesized, early leukocyte chemoattractant that signals via its cell surface receptor, leukotriene receptor 1 (BLT1), to attract and activate leukocytes during inflammation. A role for the LTB4–BLT1 pathway in allergen-induced airway hyperresponsiveness inflammation not well defined. Objectives: To define of LTB4 (BLT1) development altered function. Methods: BLT1-deficient (BLT1−/−) mice wild-type were sensitized ovalbumin by intraperitoneal...
Spleen tyrosine kinase (Syk) is important for Fc and B-cell receptor-mediated signaling.To determine the activity of a specific Syk inhibitor (R406) on mast cell activation in vitro development allergen-induced airway hyperresponsiveness (AHR) inflammation vivo.AHR were induced after 10 d allergen (ovalbumin [OVA]) exposure exclusively via airways absence adjuvant. This approach was previously established to be IgE, FcepsilonRI, dependent. Alternatively, mice passively sensitized with...