A5058445531- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Urologic and reproductive health conditions
- Sarcoma Diagnosis and Treatment
- Testicular diseases and treatments
- Renal cell carcinoma treatment
- Prostate Cancer Diagnosis and Treatment
- Circadian rhythm and melatonin
- Intestinal and Peritoneal Adhesions
- Prostate Cancer Treatment and Research
- Adrenal and Paraganglionic Tumors
- Birth, Development, and Health
- Urological Disorders and Treatments
- Ovarian cancer diagnosis and treatment
- Cancer, Hypoxia, and Metabolism
- Urinary Bladder and Prostate Research
- Sexual Differentiation and Disorders
- Hormonal Regulation and Hypertension
- Wnt/β-catenin signaling in development and cancer
- Multiple and Secondary Primary Cancers
- Vascular Tumors and Angiosarcomas
- Ferroptosis and cancer prognosis
- Surgical Simulation and Training
- Ureteral procedures and complications
- Spaceflight effects on biology
University of Tsukuba
2016-2025
Kyoto University
2022
Tsukuba Medical Center Hospital
2022
Shizuoka General Hospital
2018-2020
Osaka University
1982
Institute for Laser Technology
1982
ABSTRACT Introduction Secondary extramammary Paget's disease features intraepidermal carcinoma caused by tumor invasion and migration into adjacent skin. Case Presentation A 68‐year‐old man underwent radical cystectomy bilateral cutaneous ureterostomy for bladder cancer right ureteral cancer. Postoperative follow‐up computed tomography urine cytology at 3 years suggested recurrence. Contemporaneous erythema bulging of the skin around ureterocutaneous fistula were observed, necessitating...
Abstract Background Genitourinary sarcomas are rare in adults and few large-scale studies on adult genitourinary sarcoma reported. We aimed to elucidate the clinical characteristics, survival outcomes, prognostic factors for overall of Japan. Methods A hospital-based cancer registry data Japan was used identify enroll patients diagnosed with 2013. The datasets were registered from 121 institutions. Results total 116 men 39 women included, a median age 66 years. most common primary site...
Urological education is as important surgical training for undergraduates. However, students in undergraduate medical schools have less exposure to urology their curriculum focuses more on clinical skills, particularly community-based healthcare a super-aging society. This study aimed evaluate whether urology-related hands-on could increase the interest of urology.A 1-day elective program urological surgery at University Tsukuba, robotic, laparoscopic, and endoscopic surgeries, was offered...
: Identification of patient subclasses that correlate with the diagnostic performance photodynamic (PDD)-assisted transurethral resection bladder tumors (TURBT) may improve outcomes. Data were extracted from patients underwent PDD-assisted TURBT at University Tsukuba Hospital between 2018-2023. Sensitivity and specificity evaluated based on PDD findings (excluding WL findings) pathology results. Cluster analysis using uniform manifold approximation projection k-means methods was performed,...
Peripheral clocks function to regulate each organ and are synchronized though various molecular behavioral signals. However, signals that entrain the bladder clock remain elusive. Here, we show glucocorticoids a key cue for in vitro vivo. A pBmal1-dLuc human urothelial cell-line showed significant shifts gene expression after cortisol treatment. In vivo, rhythmic was unchanged by bilateral adrenalectomy but shifted 4 h forward corticosterone administration at inactive phase. Moreover, 8-12...
Worsening lower urinary tract symptoms (LUTS) are a frequent adverse event following proton beam therapy (PBT) for localized prostate cancer. We investigated the differences in worsening LUTS among patients who received PBT at different times of day.Among 173 underwent cancer, 168 (median age 68.5 years) completed international symptom score (IPSS) questionnaires and were included. Changes IPSS from baseline to end assessed by multiple linear regression analysis age, National Comprehensive...
A 74-year-old man presented at our hospital with complaints of abdominal pain, nausea, and vomiting. He had undergone laparoscopic radical cystectomy ileal conduit for urinary bladder cancer 1 month earlier. The patient distention, resonant sounds on percussion, diffuse tenderness without rebound or guarding. Abdominal CT revealed dilated jejunal loops herniated through a cord-like structure. Based these findings, emergency surgery was performed, intestinal dilatation into the space between...
Objective To examine the discrepancy between clinical and pathological T stages in patients with urothelial carcinoma of upper urinary tract treated radical surgery, to compare them corresponding bladder. Methods We used Hospital‐Based Cancer Registry data Japan extract bladder cases ( n = 3747) 6831), including renal pelvis 3295) ureter 3536) cT1‐4N0M0 diagnosed 2012–2015, histologically confirmed, surgery without chemotherapy or radiotherapy. compared T‐stage among different tumor...
To evaluate the impact of relative dose intensity for gemcitabine-cisplatin chemotherapy in patients with metastatic urothelial carcinoma.We retrospectively reviewed medical records 18 carcinoma, who received regimen as first-line between 2009 and 2015. The doses gemcitabine cisplatin were reduced or intervals treatment cycles prolonged according to efficacy adverse events during first second cycles. individually optimal was set actual per standard From third course onward, same intensity....
Objective This study investigated the efficacy of docetaxel (DOC) and cabazitaxel (CBZ) examined factors associated with prognosis patients castration‐resistant prostate cancer (CRPC) receiving DOC‐CBZ sequential treatment in Japanese real‐world data. Methods We retrospectively evaluated data for 146 who received DOC followed by CBZ. The correlations specific antigen (PSA) decrease rate time to progression between CBZ were examined. Combined progression‐free survival (PFS) overall (OS) from...
Objectives To investigate the clinical characteristics of patients with penile cancer in Japan using nationwide hospital‐based registry database. Methods Using data, we described distribution age, pathology, tumor–node–metastases classification, and first‐course treatment treated between 2012 2015. We compared patterns first‐line elderly non‐elderly patients. Results A total 1012 were diagnosed squamous cell carcinoma among 1773 tumors who registered under topography code C60. The median age...
In metastatic renal cell carcinoma (mRCC), the clinical response to immune checkpoint inhibitors (ICIs) is limited in a subset of patients and need exists identify non-invasive, blood-based, predictive biomarkers for responses. We performed RNA sequencing using whole-blood samples prospectively collected from 49 with mRCC prior administration ipilimumab (IPI) and/or nivolumab (NIVO) determine whether gene expression profiles were associated An analysis 33 complete responses (n = 5), partial...
A 54-year-old woman presented withtransient back pain. She was diagnosed withleiomyosarcoma of the inferior vena cava (IVC) by computed tomography (CT) and referred to our hospital. Contrastenhanced CT revealed a mass (38×42 mm) located in retroperitoneal space along course right ovarian vein. The compressed IVC into crescent shape. tumor thrombus also found IVC. 18 F-fluoro-2-deoxy-D-glucose positron emission (PET) high uptake at caudal side tumor. These radiological findings strongly...
Objectives Molecular analysis of tumor tissues has been extensively analyzed in germ cell tumors. However, genetic plasma circulating DNA limited. Our objective was to analyze alterations as well its impact on prognosis patients with chemo‐refractory Methods We included 13 tumors who relapsed after second‐line or higher previous chemotherapy and performed targeted sequencing cell‐free using an AVENIO Expanded kit. Results Tumor‐specific were identified all patients. The most frequently...
No standard procedure has been established for laparoendoscopic single-site surgery urachal remnants (LESS-U). This study aimed to report the novel surgical techniques and initial outcomes of with an extraperitoneal approach through a suprapubic port (spLESS).Fifty-five patients (median age, 27 years; range, 15-69 years) who underwent LESS-U were analyzed. To overcome limitations inherent in conventional (LESS-U umbilical port: uLESS), we modified placement approached via space. spLESS is...
We reported two cases of hyperthyroidism that developed during induction chemotherapy for advanced germ cell tumors with high serum human chorionic gonadotropin (hCG) levels. Case 1 : An 18-year-old man mediastinal choriocarcinoma complained tachycardia and tremor. His pretreatment hCG level was 1.37 million mIU/ml. The free thyroxine (fT4) measured on day 2 the first course bleomycin, etoposide cisplatin (BEP) elevated to 7.8 ng/dl (＜1.7 ng/dl), whereasthe thyroidstimulating hormone (TSH)...
Abstract Peripheral clocks function to regulate each organ and are synchronized though various molecular behavioral signals. However, signals that entrain the bladder clock remain elusive. Here, we show glucocorticoids a key cue for in vitro vivo . A p Bmal1 -dLuc human urothelial cell-line showed significant shifts gene expression after cortisol treatment. In , rhythmic was unchanged by bilateral adrenalectomy but shifted 4 hours forward corticosterone administration at inactive phase....
Objective To identify the clinicopathological features of adrenal malignancies and analyze prognoses patients with cortical carcinoma (ACC) malignant pheochromocytoma (MPCC). Patients methods We used a hospital‐based cancer registry data in Japan to extract cases that were histologically confirmed, diagnosed, initially treated from 2012–2015. For survival analysis, we 2008–2009 cohort estimate 5‐year overall (OS) by Kaplan–Meier method. Results A total 989 identified 2012–2015 cohort. The...
Abstract Background To identify the prognostic impact of treatment centralization in patients with testicular germ cell tumors (TGCT). Methods We used a hospital-based cancer registry data Japan to extract seminoma and non-seminoma cases that were diagnosed 2013, histologically confirmed, received first course treatment. compare 5-year overall survival (OS) rates stratified by institutional care volume, we performed Cox proportional hazards regression analysis using inverse probability...
Abstract Objectives We aimed to elucidate the clinical characteristics, survival outcomes and prognostic factors for overall of adult genitourinary sarcoma in Japan. Methods A hospital-based cancer registry data Japan was used identify enroll patients diagnosed with 2013. The datasets were registered from 121 institutions. Results total 116 men 39 women included, a median age 66 years. most common primary site kidney 47 patients, followed by paratestis 36 patients. histological type...
A technique capable of determining proton energies below 1 MeV by the Boron-Nitride (BN) nuclear activation method is described. This convenient and can be used even in a gas plasma. situation often occures light ion beam transport experiment for particle fusion research. Activation results were compared with obtained from biased charge collectors.
A 66-year-old male with bladder cancer underwent radical cystectomy and ileal conduit construction. The pathological diagnosis was urothelial carcinoma squamous differentiation (pT3b). Computed tomography (CT) 18 months postoperatively revealed a right external iliac lymph node metastasis. He treated systemic chemotherapy after placement of bilateral ureteral stents, but CT following an increase in the size metastasis, patient diagnosed progressive disease. Radiotherapy to metastasis...