A5022111952- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory and Cough-Related Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Plant Molecular Biology Research
- Plant Reproductive Biology
- Respiratory Support and Mechanisms
- Accounting and Organizational Management
- Operations Management Techniques
- Allergic Rhinitis and Sensitization
- Prosthetics and Rehabilitation Robotics
- Soft Robotics and Applications
- Photosynthetic Processes and Mechanisms
- Hydraulic and Pneumatic Systems
- Sinusitis and nasal conditions
- Sarcoidosis and Beryllium Toxicity Research
- Sarcoma Diagnosis and Treatment
- Analytical Chemistry and Chromatography
- Cancer Immunotherapy and Biomarkers
- Innovation and Knowledge Management
- Urologic and reproductive health conditions
- Collaboration in agile enterprises
- Corporate Taxation and Avoidance
- Molecular spectroscopy and chirality
- Muscle activation and electromyography studies
Yamaguchi University
1995-2025
University of Tsukuba
2018-2024
Okayama Shoka University
2023
Meiji University
2008-2022
Okayama University
2008-2021
Kwansei Gakuin University
2007-2016
Ryukoku University
2013-2016
Showa University Hospital
2014
Kagoshima University
2010
Osaka University
2010
Gibberellins (GAs) play important roles in regulating reproductive development, especially anther development. Our previous studies revealed that the MYB transcriptional factor GAMYB, an component of GA signaling cereal aleurone cells, is also for Here, we examined physiological functions during development through phenotypic analyses rice (Oryza sativa) GA-deficient, GA-insensitive, and gamyb mutants. The mutants exhibited common defects programmed cell death (PCD) tapetal cells formation...
Plant male reproductive development is highly organized and sensitive to various environmental stressors, including high temperature. We have established an experimental procedure evaluate temperature injury in japonica rice plants. High treatment (39°C/30°C) starting at the microspore stage repeatedly reduced spikelet fertility our system. Morphological observations revealed that pollen viability plants exposed temperatures was lower than control Most grains temperature-treated displayed a...
Gene expression throughout the reproductive process in rice (Oryza sativa) beginning with primordia development through pollination/fertilization to zygote formation was analyzed. We analyzed 25 stages/organs of including early microsporogenesis stages 57,381 probe sets, and identified around 26,000 expressed sets each stage. Fine dissection combined detailed microarray profiling revealed dramatic, coordinated finely tuned changes gene expression. A decrease genes pollen maturation observed...
Recent advances in biologics have provided new insights into the clinical course of asthma, including disease modification, remission (CR), and deep (DR). However, extent to which achieve CR DR severe asthma patients is poorly understood.To assess achievement rate predictors using long-term biologics, we retrospectively evaluated 54 recently started on biologics. "CR" denotes all three criteria: (1) absence symptoms, (2) no exacerbations, (3) use oral corticosteroids. denoted plus (4)...
The male gametophyte and tapetum play different roles during anther development although they are differentiated from the same cell lineage, L2 layer. Until now, it has not been possible to delineate their transcriptomes due technical difficulties in separating two types. In present study, we characterized separated of rice microspore/pollen using laser microdissection (LM)-mediated microarray. Spatiotemporal expression patterns 28,141 anther-expressed genes were classified into 20 clusters,...
Similarity of gene expression profiles provides important clues for understanding the biological functions genes, processes and metabolic pathways related to genes. A network (GEN) is an ideal choice grasp such profile similarities among genes simultaneously. For GEN construction, Pearson correlation coefficient (PCC) has been widely used as index evaluate pairs. However, calculation PCCs all pairs requires large amounts both time computer resources. Based on correspondence analysis, we...
Correlations of gene-to-gene co-expression and metabolite-to-metabolite co-accumulation calculated from large amounts transcriptome metabolome data are useful for uncovering unknown functions genes, functional diversities gene family members regulatory mechanisms metabolic pathway flows. Many databases tools available to interpret quantitative data, but there only limited ones that connect correlation biological knowledge can be utilized find significance it. We report here a new database,...
ABSTRACT Many plant species are susceptible to high‐temperature (HT) injury during reproductive development. We recently demonstrated that HT represses the expression of YUCCA auxin biosynthesis genes and reduces endogenous in developing anthers barley Arabidopsis . Here, we show DNA proliferation mitochondria, chloroplasts nuclei panicles is inhibited with increasing temperatures barley. Following suppression, terminal abnormalities were observed organelles anther wall cells, including...
Unstable and low absorption of laser energy is experienced in copper welding at around 1000 nm wavelength. At 532 wavelength, there stable high by copper. Past researches have shown that transitional processing condition between keyhole heat conduction results a micro-welding process characterized good surface quality deep penetration. In order to adapt using pulsed Nd:YAG lasers, investigations efficiency were addressed. Processing was done under welding. Copper C1020 specimens processed...
Abstract Although the 6 min walk test (6MWT) is well-established for assessing desaturation in patients with interstitial lung disease (ILD), it cannot be easily performed primary healthcare settings. This retrospective observational study aimed to evaluate usefulness of 1 sit-to-stand (1STST) during 6MWT ILD normal resting blood oxygen levels. We included 116 patients, and pulse saturation (SpO 2 ) both methods was analyzed. The SpO nadir 1STST correlated strongly (ρ = 0.82). frequency <...
Yellow nail syndrome (YNS), a rare condition characterized by thickened yellow nails, lymphedema, and respiratory manifestations, is rarely caused bucillamine, an anti-rheumatic agent. Respiratory manifestations of YNS include chylothorax in 18.8%-22% patients with pleural effusion. We herein report the first case bucillamine-induced chylothorax. Lymphangiography revealed narrowing lymphatic vessels stagnation fluid, suggesting impaired drainage. The persisted despite discontinuation...
Cool temperature conditions are known to lead pollen sterility in rice. Pollen is an agriculturally important phenomenon because it imparts a large influence directly on rice yield. However, cool stress tolerance varies among cultivars and avoidance of difficult by practical method agriculture. In this study using two cultivars, Hitomebore (high tolerance) Sasanishiki (low tolerance), we analyzed morphological features gene expression profiles, under stress, anther development was given (19...
Objective: Asthma is frequently associated with chronic rhinosinusitis nasal polyps (CRSwNP). Although endoscopic sinus surgery (ESS) improves asthma control in CRSwNP patients asthma, the mechanism that underlies response to surgical treatment still unclear. We evaluated relevance of changes and airway/systemic inflammation eosinophilic not well controlled who underwent ESS.Methods: prospectively assessed questionnaire (ACQ) score, blood eosinophil counts (B-Eos), forced expiratory volume 1...
(1) Background: Reduced lung function in early adulthood is associated with future risks to health outcomes that have not been fully explored by gender. We investigated gender-specific relationships between and extrapulmonary variables, assessing their potential as screening markers for respiratory dysfunction young adults. (2) Methods: The participants were 151 medical students. Clinical data, handgrip strength (HS); body composition parameters such skeletal muscle mass index (SMI),...
The size and shape of the chiral cavity a macrocyclic receptor were tuned by alteration binaphthyl moiety to improve recognition/discrimination ability. For example, host 3 with 3,5-bis(trifluoromethyl)phenyl group at 3,3′-positions showed improved enantioselectivity for small molecules such as 2-chloropropionic acid methyl lactate evaluated binding constants. This also had an excellent ability NMR solvating agent.
Cytoplasmic male sterility (CMS) is one of the most ideal phenomena known in higher plants to describe incompatibilities between mitochondrial-nuclear genomic interactions. To elucidate dependency pollen development on mitochondrial genotypes and cytoplasmic-nuclear barriers, we employed five CMS isogenic lines rice, CW-, W11-, LD-, BT- WA-type lines, that exhibit distinct pollen-defective phenotypes, characterized phenotypes nuclear gene expression patterns conjunction with their...
Chronic obstructive pulmonary disease (COPD) is a heterogeneous inflammatory lung disease. It important to identify patients who would respond anti-inflammatory treatment. This prospective study aims determine how biomarkers could be used predict the potential effect of inhaled corticosteroids (ICS) in terms symptoms and function. We evaluated levels blood eosinophils, exhaled nitric oxide fraction at flow rate 50 ml s-1 (FeNO), alveolar concentration (Calv), immunoglobulin E atopy 43 with...
Chiral macrocycles with the hydrogen bond donor/acceptor sites in cavity were synthesized and covalently bonded to silica gel give chiral stationary phases (CSPs), which showed excellent abilities resolve various compounds including ketones, esters, carboxylic acids, sulfoxides, amines, amino acid derivatives, metal complexes. The effect of linker connecting macrocyclic moiety was examined, a more electronegative substituent found be better. Various organic solvents could used as mobile...
Bud dormancy in temperate woody perennials is a complex process consisting of three different stages; paradormancy, endodormancy, and ecodormancy. Endodormant buds differ from the other types dormant that they cannot resume growth under favorable conditions. Because endodormant require certain amount chilling accumulation for transition to ecodormancy, genes showing chilling-mediated differential expression patterns are candidates internal factors controlling endodormancy. To search...
Abstract Background Genitourinary sarcomas are rare in adults and few large-scale studies on adult genitourinary sarcoma reported. We aimed to elucidate the clinical characteristics, survival outcomes, prognostic factors for overall of Japan. Methods A hospital-based cancer registry data Japan was used identify enroll patients diagnosed with 2013. The datasets were registered from 121 institutions. Results total 116 men 39 women included, a median age 66 years. most common primary site...
Sedentary behavior and cognitive impairment have a direct impact on patients’ outcomes. An energy metabolic disorder may be involved in the overlap of these comorbid conditions (motoric risk (MCR)) patients with chronic obstructive pulmonary disease (COPD). We aimed to explore linkage between proapoptotic protein, growth differentiation factor (GDF)-15, MCR. Physical activity (PA), function (Japanese version Montreal Cognitive Assessment: MOCA-J), serum GDF-15 levels were assessed healthy...