PURPOSE: We have introduced magnifying colonoscopy into clinical practice and analyzed its diagnostic efficacy, especially regarding the ability to distinguish neoplastic from non-neoplastic polyps. METHODS: The materials consisted of 923 After identifying lesions during normal colonoscopy, a dye was sprayed, then zoom apparatus colonoscope used make magnified observation at maximum 100 times magnification. classified crypt orifices six categories labeled them A F as follows: A, medium round...

Nonalcoholic steatohepatitis (NASH) occurs worldwide and is characterized by lipid accumulation in hepatocytes, hepatic inflammation, fibrosis, an increased risk of cirrhosis. Although a major proportion NASH patients exhibit obesity insulin resistance, 20% lack high body mass are categorized as “non-obese NASH”. Time-restricted feeding (TRF), limiting daily food intake within certain hours, improves obesity, metabolism, liver inflammation. Here, we determined whether TRF affects pathology...

Polymethoxyflavones are flavonoids that abundant in citrus fruit peels and have beneficial effects on human health. Previous studies demonstrated the polymethoxyflavones, namely sudachitin nobiletin, ameliorate obesity diabetes humans rodents. Although nobiletin induces lipolysis adipocytes, lipolytic pathway activation by has not been clarified adipocytes. In this study, effect of was elucidated murine 3T3-L1 Glycerol release into medium cyclic AMP (cAMP)/protein kinase A...

Background:Right ventricular (RV) volumetric and functional assessments are both crucial for the management of patients with hypoplastic left heart syndrome (HLHS). 3-dimensional echocardiography (3DE) volume measurements 2D speckle-tracking (2D-STE) strain analysis performed separately. 3D-STE is capable evaluating those parameters simultaneously providing principal (PS), unifying concepts myofiber orientation contraction into a single, maximal contractile direction. However, application to...

We have cloned from rat brain a family of alternatively spliced cDNAs single gene, which encodes norepinephrine transporter (NET) having variations at the 3′-region including both coding and noncoding regions. This produces two isoforms, rNETa rNETb, differ their COOH termini. The isoform reveals terminus homologous to human NET transports norepinephrine. In contrast, rNETb revealed no detectable transport function but reduced functional expression when isoforms were expressed in same cell....

A coculture method with a pathogenic actinomycete of the genus Nocardia and an animal cell line was designed to reconstruct emulate initial infection state, new cyclic nonapeptide, named nocarjamide (1), obtained by tenerifensis IFM 10554T mouse macrophage-like J774.1 in modified Czapek–Dox medium. Nocarjamide (1) exhibited Wnt signal-activating effects.

Troglitazone, a member of the thiazolidinedione class antidiabetic drugs, was withdrawn from market because it causes severe liver injury. One mechanisms for this adverse effect is thought to be mitochondrial toxicity. To investigate characteristics troglitazone-induced toxicity in more depth, toxicological effects troglitazone on hepatocytes and mitochondria were investigated using rat model type 2 diabetes mellitus (T2DM). Troglitazone found increase permeability transition (MPT) diabetic...

To achieve higher power supply reliability, it is important to reduce lightning outages. In addition, the cost-benefit of protection methods should be good. Many factors including causes surge, topology and insulation level distribution lines considered establish efficient for lines. Furthermore, necessary clarify flashover characteristics 6.6-kV insulators examine coordination throughout system. This study experimentally clarifies currently used by considering polarity differences pollution...

Heart failure is a progressive pathology that represents the main life-threatening cardiac disease. Its models are typically based on clinical observations and not consistently predictive. This study employs an approach both fluid dynamics solid mechanics to uncover flow-tissue interplay may anticipate development of heart failure. The physiological fluid-structure interaction analyzed in children with single right ventricle (SRV), where has been surgically transformed take role...

In Japan, porcelain-housed internally gapped lightning surge arresters are applied for 6.6kV distribution lines. A arrester is composed of Metal Oxide Varistors (MOVs) and an internal gap, which installed in a porcelain housing having sealing structure. It well known that dominant degradation factor follow current interrupting ability MOV. This paper focused on degraded MOV due to current. The characteristics examined by measuring the reference voltage after impulse currents variation...

Right atrial (RA) mechanics have been studied infrequently in children the past due to technical constraints. With advent of strain imaging, RA physiology can now be greater detail. The principal aim this study was describe functional changes right heart with idiopathic pulmonary arterial hypertension (PAH), by using new applications strain. In retrospective study, we evaluated 20 patients (age range = 3–23 years) PAH and 18 control patients. longitudinal (RALS) displacement (LD) were...

Abstract A stereoselective synthetic route to chiral C3‐spirooxindole‐ and C2‐spiropseudoindoxyl‐pyrrolidines was accomplished by an enantioselective organocatalyzed Pictet‐Spengler reaction of tryptamines isotryptamines followed a diastereoselective oxidative rearrangement using eco‐friendly oxidants (i. e., NaOCl ⋅ 5H 2 O Oxone®). This sequential enables rapid access in one‐pot process. Wnt signaling inhibitory assay the prepared enantioenriched spiro compounds demonstrated that they...

Insulated wires are clarified to have different characters from bare conductors in the viewpoint of lightning performance by experiments a laboratory and field surveys. First, attachment manner strokes an insulated wire has been studied using high voltage impulse generator. Sparkover between rod electrode (high side) is 6-7% higher than conductor for negative polarity. Second, when insulator (small capacitance) combined with (large capacitance), accounts large part total applied flashover...

PURPOSE: No prospective observations of “flat” tumors the colon have yet been reported. The purpose this study was to investigate progression small flat by using colonoscopy. METHODS: shapes were classified into three types, including slightly elevated lesions with a top (flat-top type), wide depression in center (wide-depressed and slit-like (slit-depressed type). A total 14 13 patients (2 women; median age, 58; range, 46-72 years) examined project. All cases followed up prospectively...

Described herein is the case of an 8‐year‐old boy who developed a hepatic nodular lesion after having received anti‐neoplastic therapy for nephroblastoma. Histological examination excised specimen indicated disordered arrangement components with hemangioma‐like features. This was diagnosed as variant focal hyperplasia. It speculated that this late complication treatment nephroblastoma and might develop from congenital malformative area liver.