A5000159004- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- Cardiomyopathy and Myosin Studies
- Cardiac Structural Anomalies and Repair
- Mechanical Circulatory Support Devices
- Congenital Heart Disease Studies
- Cardiac Imaging and Diagnostics
- Elasticity and Material Modeling
- Cardiovascular Effects of Exercise
- Cardiac electrophysiology and arrhythmias
- Advanced MRI Techniques and Applications
- Pulmonary Hypertension Research and Treatments
- Vascular anomalies and interventions
- Cardiac pacing and defibrillation studies
- Cardiac Arrhythmias and Treatments
- Probabilistic and Robust Engineering Design
- Tissue Engineering and Regenerative Medicine
- Cardiac and Coronary Surgery Techniques
Icahn School of Medicine at Mount Sinai
2024-2025
University of Trieste
2018-2024
University of Bologna
2022
Abstract Background The LV myocardial strain and hemodynamic forces (HDFs) are innovative markers of function. Aortic coarctation is safely repaired in infancy; however, mortality morbidity remain increased later life. study investigated the role left ventricular deformation HDFs asymptomatic patients who underwent successful aortic repair. Methods Clinical echocardiographic data were analyzed from 42 CoA, 32 ± 20 years after surgery, 2D global longitudinal (GLS), circumferential (GCS)...
The geometric properties of the mitral valve (MV), controlling inflow blood to left ventricle (LV), is a primary subject study in clinical cardiology since its movements represent central points for differentiating physiological from pathological conditions. ability describing and modeling MV-LV dynamics fundamental improving MV repair surgical procedure. realistic challenging each individual patient because mechanical tissues are not accessible noninvasively, making rigorous fluid–structure...
The clinical syndrome of mitral insufficiency is a common consequence valve (MV) prolapse, when the MV leaflets do not seal closed orifice and blood regurgitates back to atrium during ventricular contraction. There are different types prolapse that may influence degree regurgitation also in relation left ventricle (LV) geometry. This study aims provide some insight into fluid dynamics view improving measurements available setting. analysis performed by computational model coupled with an...
The right and left sides of the human heart operate with a common timing pump same amount blood. Therefore, ventricle (RV) presents function that is comparable to (LV) in terms flow generation; nevertheless, RV operates against much lower arterial pressure (afterload) requires muscular strength. This study compares fluid dynamics normal ventricles better understand role streamlined geometry provide some physics-based ground for construction clinical indicators side. analysis performed by...
Background Advancements in cardiac imaging have revolutionized our understanding of ventricular contraction. While ejection fraction (EF) is still the gold standard parameter to assess left ventricle (LV) function, strain (SI) has provided valuable insights into mechanics. The lack an integrative method including SI parameters a single, validated formula may limit its use. Our aim was compare different methods for evaluating global circumferential (GCS) and their relationship with...
ims: Despite continuous efforts in improving the selection process, rate of non-responders to cardiac resynchronization therapy (CRT) remains high. Recent studies on intraventricular blood flow suggested that alignment hemodynamic forces (HDFs) may be a reproducible biomarker mechanical dyssynchrony. We aimed explore relationship between pacing-induced realignment HDFs and positive response CRT. Methods results: retrospectively analyzed 38 patients from CRT database our institution...
Heart failure is a progressive pathology that represents the main life-threatening cardiac disease. Its models are typically based on clinical observations and not consistently predictive. This study employs an approach both fluid dynamics solid mechanics to uncover flow-tissue interplay may anticipate development of heart failure. The physiological fluid-structure interaction analyzed in children with single right ventricle (SRV), where has been surgically transformed take role...
Abstract Recent developments on the grading of cardiac pathologies suggest flow-related metrics for a deeper evaluation function. Blood flow employs space-time resolved cardiovascular imaging tools, possibly integrated with direct numerical simulation (DNS) intraventricular fluid dynamics in individual patients. If patient-specific analysis is promising method to reproduce details or assist virtual therapeutic solutions, it becomes impracticable nearly-real-time during routine clinical...
The study of valve asymmetry represents an important avenue for modern cardiac surgery. correct choice leaflet reconstruction may indicate a new path in the quality and long-term survival patients. A systematic investigation was performed with total 25 numerical simulations using healthy ventricle ideal varying degrees asymmetry. An overall assessment is made terms vorticity, kinetic energy, dissipated hemodynamic forces. results that optimal to consider repair or prosthetic design between...
Double outlet right ventricle (DORV) is a malformation of the fetal heart in utero that affects ventricular chambers. It usually presents with displacement aorta and more than half circumference both arterial valves ventricle. A peculiar characteristic given by an interventricular septal defect (VSD), which allows communication between left consequent mixing oxygenated non-oxygenated blood inside cavities. crucial question assessing degree severity functional dysfunction concerns percentage...
The entry of blood into the left ventricle is regulated by two valve leaflets. Mitral prolapse primary cause mitral regurgitation. repair gold standard therapeutic procedure for patients with degenerative regurgitation and follows fundamental principles: restoring a good coaptation surface flap correcting annular dilation. This study presents first step in direction addressing influence geometry on fluid dynamics To this end, it develops systematic analysis to identify how level efficiency...
<title>Abstract</title> Heart failure (HF) is a life-threating cardiac disease that develops progressively for the reduced ability of left ventricle (LV) to pump blood into circulation during systole. HF can also develop in patients with preserved systolic function, typically presence hypertrophic cardiomyopathy (HCM). This type sometimes termed as diastolic HF, but its biomechanical origin still unclear. study employs physics-based analysis both LV and atrium (LA) selected HCM matched...
Background: Progressive systolic dysfunction is considered an important risk factor for Fontan failure. Previously we have shown that principal strain (PS) a novel 3D concept provides insights into deformation of single right ventricle (SRV). In this study, plan to apply the PS in patients with left (SLV). Hypothesis: may predict composite outcomes post-Fontan patient SLV. Methods: We prospectively enrolled 48 SLV (median age: 12.4 years), 64 SRV, and 102 age-matched controls (12.4 years)....
Abstract Funding Acknowledgements Type of funding sources: None. Introduction. Aortic stenosis (AS) is one the most common valvular heart diseases; however, association between left ventricular (LV) myocardial deformation and hemodynamic forces (HDFs) still mostly unexplored. Purpose. This study aimed to assess differences in LV HDFs a large cohort patients with aortic retrospectively. Methods. Two-hundred fifty-four subjects (median age 77 years, 50% women) preserved ejection fraction...
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Introduction: Adult mammals, including humans, fail to regenerate the majority of lost cardiomyocytes (CMs) that are replaced with scar tissue after injury. This lack regenerative response is due loss proliferative capacity adult CMs which in mice occurs 7 days birth. An vitro model recapitulates these changes has not been developed yet. Hypothesis: Using rat engineered heart tissues (rEHT) we have a custom-made cryoinjury system test hypothesis maturation EHTs regulates Methods: rEHT were...