A5014512431- Congenital Heart Disease Studies
- Pulmonary Hypertension Research and Treatments
- Neonatal Respiratory Health Research
- Cardiovascular Function and Risk Factors
- Cardiac Structural Anomalies and Repair
- Heart Failure Treatment and Management
- Cardiovascular Issues in Pregnancy
- Congenital Diaphragmatic Hernia Studies
- Cardiac Arrhythmias and Treatments
- Mechanical Circulatory Support Devices
- Transplantation: Methods and Outcomes
- Cardiomyopathy and Myosin Studies
- Hemodynamic Monitoring and Therapy
- Congenital heart defects research
- Neurogenetic and Muscular Disorders Research
- Systemic Lupus Erythematosus Research
- Cardiac Valve Diseases and Treatments
- Cell Adhesion Molecules Research
- Tumors and Oncological Cases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Spinal Dysraphism and Malformations
- Pregnancy and preeclampsia studies
- Connective tissue disorders research
- Obstructive Sleep Apnea Research
- Vascular anomalies and interventions
University of California, San Francisco
2014-2024
Institute of Cardiology
2024
Pediatrics and Genetics
2021-2024
University of California System
2024
UCSF Benioff Children's Hospital
2015-2024
Children's Hospital of Philadelphia
2015-2018
University of Pennsylvania
2016
Abstract Cardiac catheterization remains the gold standard for diagnosis and management of pediatric pulmonary hypertension (PH). There is lack consensus regarding optimal anesthetic airway regimen. This retrospective study describes anesthetic/airway experience our single center cohort PH patients undergoing catheterization, in which obtaining hemodynamic data during spontaneous breathing preferential. A total 448 catheterizations were performed 232 patients. Of 379 cases that began with a...
Fetal cerebrovascular resistance is influenced by several factors in the setting of intact autoregulation to allow for normal cerebral blood flow and oxygenation. Maternal hyperoxygenation (MH) allows acute alterations fetal physiology can be a tool test reactivity late-gestation fetuses. In this study, we utilized MH evaluate fetuses with specific congenital heart disease (CHD).This was cross-sectional study complex CHD compared controls without CHD. cases were grouped according into:...
Pulmonary hypertension (PH) is relatively common in infants with severe bronchopulmonary dysplasia (BPD), however, hemodynamic data and factors associated mortality this patient group are sparsely described the literature.To characterize hemodynamics of former preterm BPD PH, as measured at cardiac catheterization, to identify respiratory cardiovascular predictors mortality.Single-center, retrospective cohort study, including, 30 patients born less than 32-week gestational age (GA), who had...
We present a case of late preterm infant placed on extracorporeal life support in the first day for persistent pulmonary hypertension newborn. Developmental arrest, vascular hypertensive changes, and interstitial glycogenosis were lung biopsy at 7 weeks age. Pulmonary has persisted through childhood. Genetic testing 8 years identified novel mutation TBX4.
Left ventricular (LV) dysfunction after orthotopic heart transplantation (OHT) is multifactorial and can be an indicator of graft rejection or coronary artery vasculopathy. Analysis rotational mechanics may help in the early diagnosis dysfunction. Studies describing left strain children OHT are lacking. It important to establish baseline pediatric pursue further studies this population.Rotational measured by speckle tracking was compared 32 OHT, with no evidence active vasculopathy 35...
To describe the typical clinical course of reversible persistent pulmonary hypertension newborn (PPHN) from perinatal etiologies and compare that with PPHN due to underlying fetal developmental etiologies.
Pulmonary arterial hypertension (PAH) is a frequent complication of congenital heart disease as consequence altered pulmonary hemodynamics with increased blood flow and pressure. The development vascular (PVD) in this patient population an important concern determining operative strategy. Early, definitive surgical repair, when possible, the best therapy to prevent treat PVD. However, not possible some patients because they either presented late, after PVD, or have complex lesions amenable...
Despite the increase in therapeutic options, parenteral prostacyclins remain cornerstone medical management of pulmonary arterial hypertension (PAH). While use pediatric patients is well documented, less known about alternative drug delivery methods such as enteral administration. Given that routes prostacyclin administration (IV or SC) are invariably accompanied by complicated logistics and lifestyle compromises, represents an attractive treatment option. Selexipag (Uptravi®) was approved...
Inhaled iloprost (iILO) has shown efficacy in treating patients with hypoxic lung disease and pulmonary hypertension, inducing selective vasodilation improvement oxygenation. However, its short elimination half-life of 20-30 min necessitates frequent intermittent dosing (6-9 times per day). Thus, the administration iILO via continuous nebulization represents an appealing method drug delivery hospital setting. The objectives are: (1) describe our methodology safety profile mechanically...
Abstract Background Neonates with persistent pulmonary hypertension of the newborn (PPHN) can present hypoxia and right ventricular dysfunction resultant inadequate oxygen delivery end‐organ damage. This study describes use prostaglandin‐E1 (PGE) for ductal patency to preserve systolic function limit afterload in newborns PPHN. Methods is a retrospective cohort that follows hemodynamics, markers perfusion, length therapeutics, echocardiographic variables 57 who used prostglandin‐E1 setting...
Abstract Despite therapeutic advances over the past decades, pulmonary arterial hypertension (PAH) and related vascular diseases continue to cause significant morbidity mortality in neonates, infants, children. Unfortunately, an adequate understanding of underlying biology is lacking. There has been a growing interest role that genetic factors influence disease, with hope information may aid identifying disease etiologies, guide decisions, ultimately identify novel targets. In fact, current...
Abstract Introduction Pulmonary artery acceleration time (PAAT) is considered useful for the non‐invasive evaluation of pulmonary pressure (PAP) and vascular resistance (PVR). PAAT dependent on PAP, PVR, compliance, stroke volume, heart rate. Its relative dependency these determinants may differ between young older children, raising uncertainty regarding its utility in children. We aim to identify primary children less than 36 months undergoing cardiac catheterization diagnosis elevated PVR....