A5103045084- Congenital Heart Disease Studies
- Fetal and Pediatric Neurological Disorders
- Prenatal Screening and Diagnostics
- Pregnancy and preeclampsia studies
- Congenital Diaphragmatic Hernia Studies
- Congenital heart defects research
- Tracheal and airway disorders
- Cerebral Palsy and Movement Disorders
- Ultrasound in Clinical Applications
- Neonatal and fetal brain pathology
- Cardiovascular Issues in Pregnancy
- Pulmonary Hypertension Research and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Neonatal Respiratory Health Research
- Ureteral procedures and complications
- Vascular anomalies and interventions
- Maternal and fetal healthcare
- Cardiovascular Disease and Adiposity
- Urinary Bladder and Prostate Research
- Reproductive Biology and Fertility
- Cardiovascular Conditions and Treatments
- Infant Development and Preterm Care
- Sperm and Testicular Function
- Coronary Artery Anomalies
- Ectopic Pregnancy Diagnosis and Management
West China Medical Center of Sichuan University
2025
Capital Medical University
2024
Beijing Anzhen Hospital
2024
Sichuan University
2024
University of California, San Francisco
2020-2023
Guangzhou University of Chinese Medicine
2019-2022
Dalian Medical University
2022
First Affiliated Hospital of Dalian Medical University
2022
Affiliated Hospital of Guizhou Medical University
2016-2021
Guiyang Medical University
2016-2021
Abstract Congenital heart disease (CHD) is the most common birth defect. Fetal survey ultrasound recommended worldwide, including five views of that together could detect 90% complex CHD. In practice, however, sensitivity as low 30%. We hypothesized poor detection results from challenges in acquiring and interpreting diagnostic-quality cardiac views, deep learning improve CHD detection. Using 107,823 images 1,326 retrospective echocardiograms surveys 18-24 week fetuses, we trained an...
Abstract Objective To evaluate prospectively the performance of software that automatically retrieves, from a three‐dimensional (3D) volume fetal chest, three diagnostic cardiac planes in second trimester pregnancy. Methods 3D static volumes chest were acquired at level four‐chamber view 72 fetuses between 18 and 23 weeks gestation. Standardization was performed Plane A (the reference plane: view) alone. Tomographic ultrasound imaging (TUI) added to display each plane. The left ventricular...
Abstract The aim was to investigate the impact of maternal hyperoxygenation (HO) on cardiac dimensions in fetuses with isolated Coarctation (CoA). Fetal echocardiography performed serially 48 CoA and gestation age matched normal fetues. Z-scores for mitral valve (MV), tricuspid (TV), aortic (AV), ascending aorta (AAo), isthmus, pulmonary (PV), main artery (MPA), descending (DAo) were measured compared among fetuses, oxygen air. In group oxygen, 6 L/min administered mother using a face mask....
The cavum septi pellucidi (CSP) is an easily recognizable landmark in the fetal brain. CSP disappears after birth to form septum pellucidum. Children with microdeletion 22q11 (del. 22q11) were, however, reported have a persistent dilated CSP. This study was designed examine whether fetuses del.22q11.This case-control where width measured normal from 16 34 weeks and del. 22q11. correlated biparietal diameter (BPD). Reference curves were constructed, z-scores calculated.Cavum 260 showed linear...
To use three-dimensional (3D) power Doppler ultrasound to investigate cerebral blood flow perfusion in fetuses with congenital heart disease (CHD).The vascularization index (VI), (FI) and (VFI) the total intracranial volume main arterial territories (middle artery (MCA), anterior (ACA) posterior (PCA)) were evaluated prospectively compared 112 CHD normal using 3D Doppler. Correlations between indices neurodevelopment scores at 12 months of age assessed a subset group, values those...
Intratracheal administration of low molecular mass (LMM) hyaluronan (200 kDa) results in greater neutrophil infiltration the lungs TLR4(-/-) mice compared with that wild-type mice. In general, enhanced tissue is due to cell influx; however, apoptosis also plays an important role. We have assessed effects TLR4 regulation response LMM hyaluronan. found inflammatory neutrophils impaired mice, effect depends upon IFN-β-mediated TRAIL/TRAILR system. IFN-β levels were decreased hyaluronan-treated...
Abstract Congenital heart defects (CHDs) are the most common group of major birth defects. Presently there no clinically used biomarkers for prenatally detecting CHDs. Here, we performed a comprehensive maternal serum proteomics assessment, combined with immunoassays, discovery non-invasive prenatal diagnosis A total 370 women were included in this study. An isobaric tagging relative and absolute quantification (iTRAQ) proteomic approach was first to compare protein profiles pooled collected...
Fetal cerebrovascular resistance is influenced by several factors in the setting of intact autoregulation to allow for normal cerebral blood flow and oxygenation. Maternal hyperoxygenation (MH) allows acute alterations fetal physiology can be a tool test reactivity late-gestation fetuses. In this study, we utilized MH evaluate fetuses with specific congenital heart disease (CHD).This was cross-sectional study complex CHD compared controls without CHD. cases were grouped according into:...
Prenatal diagnosis of tetralogy Fallot (TOF) and hypoplastic left heart syndrome (HLHS), two serious congenital defects, improves outcomes can in some cases facilitate utero interventions. In practice, however, the fetal rate for these lesions is only 30-50 percent community settings. Improving disease therefore critical. Deep learning a cutting-edge machine technique finding patterns images but has not yet been applied to prenatal disease. Using 685 retrospectively collected echocardiograms...
ABSTRACT Objective To compare prenatal findings, associated genetic anomalies and postnatal outcome in fetuses with tetralogy of Fallot (TOF) normal cardiac axis (CAx) those abnormal CAx. Methods In this retrospective cohort study, 85 cases diagnosed TOF by ultrasound at our clinic between 2005 2015 were reviewed. Follow‐up available for 68 cases. One case complicated absent pulmonary valve syndrome a further seven postnatally other than excluded from the study. The remaining 60 confirmed...
To evaluate the efficacy of using fetal heart size measurements derived from axial echocardiography to predict homozygous α-thalassemia-1.Prospective diagnostic study.The carrier rate α-thalassemia-1 (-/αα) in China's Guangxi Zhuang Autonomous Region is approximately 15%. If both parents are carriers, risk one pregnancy 25%.Singleton mid-pregnancies at were enrolled.Fetal measurements, including diameter (HD), length (HL), circumference (HC), and area (HA), measured. The z-scores for these...
Abstract To provide useful information for diagnosing and predicting fetal intraabdominal extralobar pulmonary sequestration (IEPS), a retrospective review of diagnostic approaches was conducted. Ultrasonography performed serially in 21 fetuses with IEPS from 2005 to 2017. Prenatal sonographic features, treatment, outcomes each case were evaluated collected. These cases also compared 43 previously reported by other researchers 1986 Of the 14 (67%) hyperechoic, (100%) well circumscribed, 17...
This study aims to validate the feasibility and accuracy of a new standardized six-step approach performance focused basic obstetric ultrasound examination, compare regular performed in scheduled examination.A evaluate fetal presentation, cardiac activity, presence multiple pregnancy, placental localization, amniotic fluid volume evaluation, biometric measurements, was prospectively on 100 pregnant women between 18(+0) 27(+6) weeks gestation another 28(+0) 36(+6) gestation. The agreement...
Introduction Complete ureteral avulsion is one of the most serious complications ureteroscopy. The aim this report was to look for a good solution full-length complete avulsion. Case presentation A 40-year-old man underwent ureteroscopic management. Full-length ureter occurred during Pyeloureterostomy plus greater omentum investment outside avulsed and ureterovesical anastomosis were performed 6 hours after patient followed-up 34 months. Double-J tube removed at 3 months operation. Twenty...
To investigate the relationship between glutathione S-transferase enzyme (GSTM1, T1, and P1) genetic variants semen quality in men with idiopathic infertility.Sperm characteristics were measured using computer-assisted sperm analysis. The malondialdehyde (MDA), nitric oxide (NO), total antioxidant capacity (TAC) activities detected by spectroscopic analysis, 8-hydroxy-2'-deoxyguanosine (8-OHdG) was enzyme-linked immunosorbent assay.This study included 246 infertile 117 controls. GSTM1(-),...