A5068325299- FOXO transcription factor regulation
- RNA modifications and cancer
- Esophageal and GI Pathology
- Glutathione Transferases and Polymorphisms
- Esophageal Cancer Research and Treatment
- Sperm and Testicular Function
- Reproductive Biology and Fertility
- Hydrogen's biological and therapeutic effects
- Cancer-related molecular mechanisms research
- Drug-Induced Hepatotoxicity and Protection
- Immunotherapy and Immune Responses
- Cancer-related Molecular Pathways
- Lung Cancer Diagnosis and Treatment
- MicroRNA in disease regulation
- Reproductive Health and Technologies
- Medical Research and Treatments
- Immune Cell Function and Interaction
- Circular RNAs in diseases
- Hippo pathway signaling and YAP/TAZ
- Liver Disease and Transplantation
- Gastric Cancer Management and Outcomes
- Ubiquitin and proteasome pathways
- Animal Nutrition and Physiology
- Liver physiology and pathology
- Ferroptosis and cancer prognosis
Xi'an Jiaotong University
2006-2025
First Affiliated Hospital of Xi'an Jiaotong University
2015-2025
Poultry Research Institute
2025
Beijing University of Chemical Technology
2023
Anhui Agricultural University
2023
Institute of Biophysics
2022
Chinese Academy of Sciences
2022
Huazhong University of Science and Technology
2019
University Health Network
2015
Minimally invasive esophagectomy (MIE) was shown to be effective in reducing the morbidity and adopted increasingly. The robot-assisted minimally (RAMIE) remains initial stage of application. This study evaluated its safety feasibility by comparing short-term outcomes RAMIE video-assisted (VAMIE).Between March 2016 December 2017, 115 consecutive patients underwent or VAMIE at our institute. baseline characteristics, pathological data these two group were collected compared. propensity score...
Non-small cell lung cancer (NSCLC) is the most common and cause of cancer-related mortality globally. Increasing evidence suggested that long non-coding RNAs (lncRNAs) were involved in death. To explore possible prognostic lncRNA biomarkers for NSCLC patients, present study, we conducted a comprehensive profiling analysis based on 1902 patients from Gene Expression Omnibus (GEO) The Cancer Genome Atlas (TCGA) datasets. In discovery phase, employed 682 combination four GEO datasets (GSE30219,...
Although immunotherapy of hepatocellular carcinoma using immune checkpoint inhibitors has achieved certain success, only a subset patients benefits from this therapeutic strategy. The combination immunostimulatory chemotherapeutics represents promising strategy to enhance the effectiveness immunotherapy. However, it is hampered by poor delivery conventional chemotherapeutics. Here, shown that H-ferritin nanocages loaded with doxorubicin (DOX@HFn) show potent chemo-immunotherapy in tumor...
Blending a solution of polymerized styrene–butadiene rubber (SSBR) with natural (NR) as matrix and silane coupling agent (SCA) modified silica filler is widely used to prepare green tire tread. However, it difficult adjust the distribution in different phases blend by SCA. Moreover, reaction between SCA emits volatile organic compounds. In this work, we use new strategy improve two without Epoxidized SSBR (ESSBR) epoxidized NR (ENR) are synthesized, performance silica-filled ESSBR/ENR...
Goose astrovirus (GoAstV) has emerged as a significant pathogen affecting the goose industry in China, with GoAstV-2 becoming dominant genotype since 2017. This study explores genetic and structural factors underlying prevalence of GoAstV-2, focusing on codon usage bias, spike protein variability, stability. Phylogenetic effective population size analyses revealed that experienced rapid expansion between 2017 2018, followed by stabilization. Codon analysis indicated exhibited weaker bias...
To investigate the effects of small interfering RNA (siRNA) knockdown forkhead box M1 (FoxM1) on proliferation and invasion capacities human hepatocellular carcinoma MHCC-97H cells in vitro. The expression levels FoxM1 samples, adjacent non-hepatocellular liver samples MHCC-97 cell lines were detected by RT-PCR Western blotting. siRNA was transfected into with Lipofectamine 2000. Cell growth evaluated 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, cycle analysis...
The elderly are the majority of patients with non-small cell lung cancer (NSCLC). Compared to overall population's predictive guidance, an effective guidance for can better guide patients' postoperative treatment and improve survival (OS) disease-free (DFS). Recently, long non-coding RNAs (lncRNAs) have been found play important role in predicting tumor prognosis. To identify potential lncRNAs predict NSCLC, present study, we chose 456 NSCLC analyzed differentially expressed from four Gene...
ABSTRACT: Our objective was to investigate the genetic polymorphisms of glutathione S ‐transferase M1, T1, and P1 genes ( GSTM1 , GSTT1 GSTP1 ) assess oxidative damage in infertile men with varicoceles from northwestern China. A total 65 30 controls were included study. Multiplex polymerase chain reaction reaction–restriction fragment length polymorphism analyses used identify genotypes. Sperm DNA assessed by terminal deoxynucleotidyl transferase‐mediated dUTP‐biotin nick end‐labeling...
To investigate the hepatoprotective effects and mechanisms of hydrogen-rich water (HRW) in acetaminophen (APAP)-induced liver injury mice.Male mice were randomly divided into following four groups: normal saline (NS) control group, received equivalent volumes NS intraperitoneally (ip); HRW given (same volume as group); APAP + ip for 3 d (5 mL/kg body weight, twice a day at 8 am 5 pm) after injection; treatment) challenge. In first experiment, injected with lethal dose 750 mg/kg to determine...
Acetaminophen (APAP) overdose is a major cause of acute liver failure. Peripheral 5-hydroxytryptamine (serotonin, 5-HT) cytoprotective neurotransmitter which also involved in the hepatic physiological and pathological process. This study seeks to investigate mechanisms APAP-induced hepatotoxicity, as well role 5-HT liver's response APAP toxicity. We induced hepatotoxicity mice either sufficient serotonin (wild-type TPH1-/- plus 5- Hydroxytryptophan (5-HTP)) or lacking peripheral (Tph1-/-...
Abstract In this paper, epoxidized solution‐polymerized styrene butadiene rubber (ESSBR) as the matrix and silica filler, a small quantity of 3‐aminopropyltriethoxysilane (APTES) is used to adjust cross‐linking network ESSBR/silica. The effect two APTES addition methods (ESSBR/APTES/silica ESSBR/silica/APTES) on nanocomposite properties investigated. epoxy groups ESSBR ethoxy can react with hydroxyl improve dispersion. At same time, amino at another end increase density. Compared...
The Forkhead box M1 (FoxM1) transcription factor plays crucial roles in multiple biological processes, including cell proliferation, differentiation, migration, and transformation. Recent studies have reported that aberrant expression of FoxM1 was found a variety human cancers. However, the pattern its clinical significance hepatocellular carcinoma (HCC) not been well characterized to date. In this study, evaluated 46 pairs HCC, adjacent non-tumorous liver tissues, 12 normal tissues by...
Partner of sld five 1 (PSF1) is a member the heterotetrameric complex termed GINS. Previous studies have shown that PSF1 unregulated in several cancer and associated with tumor malignant characters. However, effects lung are still unclear. The goal this study was to investigate on proliferation capacities cancer. To start with, expression 22 human samples adjacent non-tumor were detected by real-time RT-PCR Western blotting. Our results showed overexpressed compared samples. achieve better...
Adaptor proteins are functional that contain two or more protein-binding modules to link signaling together, which affect cell growth and shape have no enzymatic activity. The actin filament-associated protein (AFAP) family is an important member of the adaptor proteins, including AFAP1, AFAP1L1 AFAP1L2/XB130. AFAP1 share certain common characteristics function as actin-binding a cSrc-activating protein. XB130 exhibits unique features in structure function. mRNA expressed human spleen,...