A5103015404- Fungal Biology and Applications
- Polysaccharides and Plant Cell Walls
- Ginseng Biological Effects and Applications
- Probiotics and Fermented Foods
- Gut microbiota and health
- Seaweed-derived Bioactive Compounds
- RNA Research and Splicing
- Prenatal Screening and Diagnostics
- Glycosylation and Glycoproteins Research
- Polysaccharides Composition and Applications
- RNA modifications and cancer
- Renal and related cancers
- Medicinal Plants and Bioactive Compounds
- Pharmacological Effects of Natural Compounds
- Microbial Natural Products and Biosynthesis
- Plant Reproductive Biology
- Reproductive Biology and Fertility
- Spinal Dysraphism and Malformations
- Cancer-related molecular mechanisms research
- E-commerce and Technology Innovations
- Lung Cancer Research Studies
- Microbial Metabolites in Food Biotechnology
- Plant biochemistry and biosynthesis
- Polyamine Metabolism and Applications
- Safety and Risk Management
Shanghai Academy of Agricultural Sciences
2017-2025
Ministry of Agriculture and Rural Affairs
2022-2024
Jilin Agricultural Science and Technology University
2023-2024
Shandong University
2024
Shenyang Agricultural University
2020-2024
Inner Mongolia Agricultural University
2024
East China University of Science and Technology
2024
Mayo Clinic in Arizona
2018-2021
China Medical University
2013-2021
Ministère de l'Agriculture et de la Souveraineté alimentaire
2018-2020
Abstract To identify candidate serum molecule biomarkers for the non-invasive early prenatal diagnosis of neural tube defects (NTDs), we employed an iTRAQ-based quantitative proteomic approach to analyze changes in samples from embryonic day (E) 11 and E13 pregnant rats with spina bifida aperta (SBA) induced by all-trans retinoic acid. Among 390 proteins identified, 40 at E11 26 displayed significant differential expression SBA groups. We confirmed 5 ELISA. observed space-time proprotein...
Polygonatum sibiricum is one of the most widely used traditional Chinese medicine in China. polysaccharide (PSP) main functional component sibiricum. In this study, a water-soluble (PSP-1) was first isolated from with molecular weight 38.65 kDa. Structural analysis performed via methylation and FT-IR spectroscopy analyses, which combination NMR spectroscopy, revealed that PSP-1 has → 4-α-D-Glcp-1 backbone substitution at O-6 β-D-Glcp-1 residues. Furthermore, exhibited potent...
Summary MicroRNAs (miRNAs) play crucial roles in plant development and secondary metabolism through different modes of sequence‐specific interaction with their targets. Artemisinin biosynthesis is extensively regulated by phytohormones. However, the function phytohormone‐responsive miRNAs artemisinin remains enigmatic. Thus, we combined analysis transcriptomics, small RNAs, degradome to generate a comprehensive resource for identifying key miRNA‐target circuits involved phytohormone‐induced...
The decreased number of viable bacteria and the ability Bifidobacterium to adhere colonize gut in gastrointestinal environment greatly limit their efficacy. To solve this problem, thiolated carboxymethyl cellulose sodium (CMC) probiotic double-layered multinucleated microcapsules with adolescentis FS2-3 inner layer Bacillus subtilis SN15-2 embedded outer layers were designed. First, counts release rates examined by vitro simulated digestion assays, it was found that better protected from...
Abstract To address the issues of probiotic activity loss during storage and feeding, as well limited efficacy single probiotics, a solution was devised by embedding mixture Bacillus coagulans SN‐8 (SN‐8) Saccharomyces boulardii SN‐6 (SN‐6) in gel. The initial step involved screening microcapsules' preparation method wall material. Using sodium alginate β‐cyclodextrin composite material chitosan outer coating allowed for an rate 82.11% microcapsules prepared air atomization method. Next,...
Spina bifida aperta are complex congenital malformations resulting from failure of fusion in the spinal neural tube during embryogenesis. Despite surgical repair defect, most patients who survive with spina have a multiple system handicap due to neuron deficiency defective cord. Tissue engineering has emerged as novel treatment for replacement lost tissue. This study evaluated prenatal approach transplanting chitosan–gelatin scaffold seeded bone marrow mesenchymal stem cells (BMSCs) healing...
To establish a new scoring system for limbal dermoid, in order to unify the diagnostic criteria and assess prognosis.A retrospective study was conducted on 261 patients with dermoid. The basic information, clinical features, pathology of dermoids were recorded, prognosis at 1 year after keratoplasty assessed follow-up. A visual created area corneal involvement, conjunctival surface shape.There 154 females 107 males mean age 4 ± 3 years surgery. After scoring, 59% (136) classified as grade I,...
Abstract Phellinus baumii , also called “Sang Huang” in China, is broadly used as a kind of health food or folk medicine Asia for its high biological activities, e.g. anti-tumor, anti-oxidation and anti-inflammatory activities. Although some previous studies have indicated that polysaccharides flavonoids showed the activity inhibiting tumor cells, active metabolites P. needs further research. In our study, stable mutant (A67), generated by ARTP mutagenesis strategy, more significantly cells...
The spore powder of Ganoderma lucidum (G. lucidum) has been proven to have a variety pharmacological activities, and it become new resource for the development health products pharmaceuticals. However, scarcity natural resources, strict growth conditions difficulty in controlling stable yield, quality different culture batches seriously limit utilization G. powder. In present study, strain with highest G0109, was selected as original generate mutants using ultraviolet ray irradiation. A...
FVPT1, a novel heteropolysaccharide, was purified from the fruiting body of
Background Fatty acids synthesized in chloroplast are transported to endoplasmic reticulum (ER) for triacylglycerols (TAGs) resembling. The development of also requires lipids trafficking from ER chloroplast. membrane contact sites (MCSs) between and has been demonstrated be involved the proteins. Lipids is often accompanied by interconversion. However, it rarely known how interconversion happens during their trafficking. Methodology/Principal Findings We cloned a lipase gene Brassica napus...
Abstract Congenital heart defects (CHDs) are the most common group of major birth defects. Presently there no clinically used biomarkers for prenatally detecting CHDs. Here, we performed a comprehensive maternal serum proteomics assessment, combined with immunoassays, discovery non-invasive prenatal diagnosis A total 370 women were included in this study. An isobaric tagging relative and absolute quantification (iTRAQ) proteomic approach was first to compare protein profiles pooled collected...
Dandelion, in China, has a long history as medicinal and edible plant, possesses high nutritional medical value. The present study aimed to isolate new polysaccharide (DLP-3) from dandelion leaves evaluate its antioxidant, antibacterial, anticancer activities. structure of DLP-3 was analyzed using HPLC, FT-IR, SEM, GC-MS, NMR spectroscopy. mainly consisted Man, Rha, GlcA, Glc, Gal, Ara with molar ratios 2.32, 0.87, 1.21, 3.84, 1.00, 1.05, respectively, molecular weight 43.2 kDa. main...
The polysaccharide is the main active substance contained in Hericium erinaceus and commonly used treatment of neurasthenia, tumors, digestive diseases. Six intracellular components were obtained from H. fruiting bodies cultivated by ARTP (atmospheric room temperature plasma) mutagenic strain (321) original (0605), respectively. This study was designed to investigate physicochemical characteristics these their potential immunomodulatory activities on RAW264.7 macrophages. results showed that...
Abstract Background Hericium erinaceus , a rare edible and medicine fungus, is widely used in the food medical field. Polysaccharides from H. are main bioactive compound that exert high value healthcare industries. Results The genome of original strain HEA was reported 38.16 Mb, encoding 9780 predicted genes by single-molecule, real-time sequencing technology. phylogenomic analysis showed had closest evolutionary affinity with Dentipellis sp . polysaccharide content fermented mycelia mutated...
Neural tube defects (NTDs) are complex abnormalities associated with gene-environment interactions. The underlying cause has not been determined. Spinal cord tissues from cases NTDs and healthy controls were collected. Methylation patterns between normal individuals compared using 450K Infinium BeadChip Illumina. DNA methylation analysis by pyrosequencing (PyroMark Q96) mRNA protein expression analyzed real-time quantitative PCR Western blotting, respectively. Next-generation Sanger...