A5100423963- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Gastric Cancer Management and Outcomes
- Pulmonary Hypertension Research and Treatments
- Lung Cancer Treatments and Mutations
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Porphyrin and Phthalocyanine Chemistry
- Neonatal Respiratory Health Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Genetic factors in colorectal cancer
- Cancer, Hypoxia, and Metabolism
- Advanced X-ray and CT Imaging
- Cancer Immunotherapy and Biomarkers
- Optical Coherence Tomography Applications
- Cancer-related molecular mechanisms research
- Colorectal Cancer Treatments and Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cervical Cancer and HPV Research
- Genomics, phytochemicals, and oxidative stress
- Medicinal Plant Pharmacodynamics Research
- Adenosine and Purinergic Signaling
- Photoacoustic and Ultrasonic Imaging
- Cancer Genomics and Diagnostics
- Neurological Complications and Syndromes
- Lung Cancer Research Studies
University of South China
2022-2025
Chinese PLA General Hospital
2012-2024
Army Medical University
2023-2024
Chongqing Medical University
2023-2024
Second Affiliated Hospital of Chongqing Medical University
2023-2024
Dalian Medical University
2023-2024
Fujian Medical University
2018-2024
Fudan University Shanghai Cancer Center
2024
Fudan University
2024
Sun Yat-sen University
2024
Molecular beacons are FRET-based target-activatable probes. They offer control of fluorescence emission in response to specific cancer targets, thus useful tools for vivo imaging. Photodynamic therapy (PDT) is a cell-killing process by light activation photosensitizer (PS) the presence oxygen. The key cytotoxic agent singlet oxygen ((1)O(2)). By combining these two principles (FRET and PDT), we have introduced concept photodynamic molecular (PMB) controlling PS's ability generate (1)O(2)...
To prepare near-infrared fluorescence imaging and photodynamic therapy agents targeted at glucose transporters, pyropheophorbide 2-deoxyglucosamide (Pyro-2DG) was synthesized evaluated in a 9L glioma rat model. Fluorescence studies demonstrate that Pyro-2DG is selectively accumulated the tumor. Upon its photoactivation, we this agent efficiently causes selective mitochondrial damage to region of tumor photoirradiated after administration agent, but does not affect tissues absence or treated...
Objective: While tissue injury and repair are known to involve adaptive immunity, the profile of lymphocytes involved their contribution dermal scarring remain unclear. We hypothesized that restoration T cell deficiency attenuates scarring. Approach: assessed temporal-spatial distribution subtypes during physiological wound process in mice. Also, we compared outcomes between wild-type (WT) severe combined immunodeficient (SCID) mice, which lymphocyte deficient. Complementary gain-of-function...
Spina bifida aperta are complex congenital malformations resulting from failure of fusion in the spinal neural tube during embryogenesis. Despite surgical repair defect, most patients who survive with spina have a multiple system handicap due to neuron deficiency defective cord. Tissue engineering has emerged as novel treatment for replacement lost tissue. This study evaluated prenatal approach transplanting chitosan–gelatin scaffold seeded bone marrow mesenchymal stem cells (BMSCs) healing...
Aim: To evaluate the novel nanoparticle reconstituted bacteriochlorin e6 bisoleate low-density lipoprotein (r-Bchl-BOA-LDL) for its efficacy as a photodynamic therapy agent delivery system in xenografts of human hepatoblastoma G2 (HepG2) tumors. Materials & methods: Bchl-BOA was encapsulated (LDL), native particle whose receptor's overexpression is cancer signature number neoplasms. Evaluation r-Bchl-BOA-LDL potential photosensitizer performed using tumor response and foot assay. Results...
Flavonoids are found in most parts of plants and have been shown to multiple biological activities such as anticancer, anti-inflammation, antibacteria, antivirus, immune-stimulation. Existing data showed that the total flavonoids Astragalus (TFA) can provide system with resistance injury possess antimutagenic, atherosclerotic inhibition, other effects. This study investigated effects TFA calycosin (a compound isolated from TFA), on apoptosis induction, cell cycle human erythroleukemia line...
Breast cancer is a common malignancy in women. More than 90% of breast deaths are caused by metastasis. Epimedii Folium (EF) commonly used herb with anti-tumor benefits, but its underlying mechanisms and active components for prevention little understood. This study assessed the therapeutic role Icariside I (ICS I) Epimedium flavonoids on lung metastasis cancer, including mechanism.
The incidence and mortality rates of esophageal squamous cell carcinoma (ESCC) have been significantly increasing in China. Indole-3-carbinol (I3C), a naturally occurring component cruciferous vegetables, is an effective cancer therapy. Yet, its effect action mechanism ESCC are still not fully understood. This study explored the role I3C vitro vivo by focusing on Wnt/β-catenin signaling pathway. MTT flow cytometry were used to assess viability apoptosis EC18 TE1 cells, while wound healing...
Dual-energy computed tomography (DECT) has received extensive attention in clinical practice; however, a quantitative assessment of published literature this domain is presently lacking. This study thus aimed to characterize the application conditions, developmental trends, and research hot spots DECT using bibliometric analysis.All on was retrieved from Web Science Core Collection (WoSCC) January 22, 2023. The co-occurrence, cooperation network, co-citation countries, institutions,...
Abstract Chinese guidelines recommend POF (paclitaxel, oxaliplatin, and 5‐FU/levoleucovorin) as first‐line treatment for advanced gastric cancer (AGC). Apatinib can augment the antitumor effect of paclitaxel, or fluorouracil in preclinical studies AGC. A phase I clinical trial was conducted to evaluate anticancer activity maximum tolerated dose (MTD) apatinib plus treatment‐naïve patients with AGC establish a recommended II dose. Participants received escalating doses daily oral (250, 375,...
E2A-PBX1 fusion gene caused by t(1;19)(q23;p13), has been well characterized in acute lymphoid leukemia (ALL). There is no report on transcripts non-small-cell lung cancer (NSCLC).We used polymerase chain reaction (PCR) to detect human NSCLC tissue specimens and cell lines. We analyzed correlation of with clinical outcomes 76 patients adenocarcinoma situ (AIS) other subgroups. compared mutation status k-ras, p53 EGFR 22 transcripts.We detected 23 184 (12.5%) 3 13 (23.1%) Presence correlated...
Abstract Objective Colorectal cancer is one of the most prevalent types worldwide. Right-sided and left-sided colorectal (RCC LCC) patients respond differently to treatment. We aimed identify different mutational profile between RCC LCC provided evidence for future precision therapy. Methods A total 630 Chinese patients, including 467 (74.1%) 163 (25.9%) RCC, were enrolled in this cohort. Both formalin-fixed paraffin-embedded tumor tissues matching blood samples collected deep sequenced...
Jie Geng Tang (JGT) is an ancient traditional Chinese herbal decoction that exhibits various pharmacological activities, however, poorly understood in the sensitivity of lung cancer to chemotherapy. Here, we explored effect JGT on sensitizing cisplatin (DDP)-resistant A549 cells (A549/DDP).Cell viability was assessed using cell counting kit-8 assay. Flow cytometry applied detected apoptosis, mitochondrial membrane potential (MMP) and reactive oxygen species (ROS) levels. Western blotting...
Posterior reversible encephalopathy syndrome (PRES) is a complication that occurs during various diseases' treatment. Imaging examination the gold standard for diagnosis. PRES frequently occurrence in patients with hematological malignancies results poorer prognosis and higher mortality. We aim to establish practical operable scale early prediction, assessment of severity Reversible Encephalopathy Syndrome, timely intervention better prognosis. The designed by reviewing literature referring...
Apatinib combined with chemotherapy might be effective and safe for the management of advanced gastric cancer, but available data are limited. To investigate efficacy safety apatinib in combination paclitaxel (PTX) alone or POF (PTX, oxaliplatin, 5-fluorouracil) patients taxane-resistant cancer.Patients cancer were enrolled single-center, open-labeled, single-arm, exploratory study (ClinicalTrials.gov #NCT02697838). was administered at 850 mg po weekly PTX regimen. The primary endpoint...
Abstract Background Studies have confirmed the prognostic value of expression status human epidermal growth factor receptor 2 (HER2) in advanced gastric cancer. However, its role early cancer (EGC) remains largely unknown. This study explored association between HER2 overexpression and clinical outcomes patients with EGC. Methods A total 211 who had undergone endoscopic treatment for pN0 EGC were enrolled. The was assessed using immunohistochemistry (IHC). Results prevalence 14.2%. showed a...