A5011487612- Congenital Heart Disease Studies
- Prenatal Screening and Diagnostics
- Fetal and Pediatric Neurological Disorders
- Congenital Diaphragmatic Hernia Studies
- Congenital Anomalies and Fetal Surgery
- Pregnancy and preeclampsia studies
- Parvovirus B19 Infection Studies
- Cardiovascular Issues in Pregnancy
- Congenital heart defects research
- Neonatal Respiratory Health Research
- Tracheal and airway disorders
- Cleft Lip and Palate Research
- Autopsy Techniques and Outcomes
- Assisted Reproductive Technology and Twin Pregnancy
- Coronary Artery Anomalies
- Cardiac Valve Diseases and Treatments
- Neonatal and fetal brain pathology
- Vascular anomalies and interventions
- Cardiac Structural Anomalies and Repair
- Spinal Dysraphism and Malformations
- Cardiac Arrhythmias and Treatments
- Craniofacial Disorders and Treatments
- Anatomy and Medical Technology
- Urological Disorders and Treatments
- Pediatric Urology and Nephrology Studies
Zentrum für Pränataldiagnostik
2015-2025
Pathodiagnostik Berlin
2018-2025
Center for Human Genetics
2014-2024
CS Diagnostics
2023
ORCID
2021
Centre Hospitalier Universitaire Hassan II
2020
German Centre of Gerontology
2019
Deutsche Nationalbibliothek
2016
Praxis (United States)
2007-2016
Charité - Universitätsmedizin Berlin
2000-2015
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Abstract Objective Prenatal diagnosis of open spina bifida is carried out by ultrasound examination in the second trimester pregnancy. The suspected presence a ‘lemon‐shaped’ head and ‘banana‐shaped’ cerebellum, thought to be consequences caudal displacement hindbrain. aim study was determine whether fetuses with this brain evident from first Methods In women undergoing routine at 11–13 weeks' gestation as part screening for chromosomal abnormalities, mid‐sagittal view fetal face obtained...
The International Society of Ultrasound in Obstetrics and Gynecology (ISUOG) is a scientific organization that encourages sound clinical practice high-quality teaching research related to diagnostic imaging women's healthcare. ISUOG Clinical Standards Committee (CSC) has remit develop Practice Guidelines Consensus Statements as educational recommendations provide healthcare practitioners with consensus-based approach, from experts, for imaging. They are intended reflect what considered by be...
The International Society of Ultrasound in Obstetrics and Gynecology (ISUOG) is a scientific organization that encourages sound clinical practice high-quality teaching research related to diagnostic imaging women's healthcare. ISUOG Clinical Standards Committee (CSC) has remit develop Practice Guidelines Consensus Statements as educational recommendations provide healthcare practitioners with consensus-based approach, from experts, for imaging. They are intended reflect what considered by be...
Abstract Objective Color Doppler echocardiography is used to visualize three transverse planes: the four‐chamber, five‐chamber, and vessels trachea views. spatio‐temporal image correlation (STIC) a new three‐dimensional (3D) technique allowing acquisition of volume data from fetal heart that displayed as cineloop single cardiac cycle. The aim study was examine potential color STIC evaluate normal abnormal hearts. Methods This prospective included 35 fetuses 27 with congenital defects (CHD)...
To analyse the spectrum of congenital heart malformations, frequency extracardiac and proportion chromosome aberrations among fetuses sent for necropsy.Necropsies were performed on 815 fetuses-448 induced abortions (55%), 220 spontaneous (27%), 147 stillbirths (18%)-during a seven year period (1991-97) in department pathology Charité Medical Centre Berlin. A defect was identified 129 cases (16%). For all fetuses, karyotyping an ultrasound examination had been performed.Congenital defects...
In 2006 the International Society of Ultrasound in Obstetrics and Gynecology (ISUOG) published practice guidelines for sonographic screening congenital heart disease (CHD) during second trimester pregnancy1. This document described two levels low-risk fetuses anomalies. Firstly, a 'basic' scan should be performed by analyzing four-chamber view fetal heart. Secondly, an 'extended-basic' further examines size relationships both arterial outflow tracts. The term 'fetal echocardiogram' was also...
Abstract Objective To measure the changes in posterior fossa first‐trimester fetuses with open spina bifida (OSB). Methods The brain stem diameter and to occipital bone (BSOB) were measured stored images of mid‐sagittal view fetal face at 11 +0 13 +6 weeks from 30 OSB 1000 normal controls. Results In control group, BSOB increased significantly crown‐rump length (CRL) ratio decreased. was above 95th percentile group 29 (96.7%) cases, below 5th 26 (86.7%) all cases. Conclusions At majority...
The International Society of Ultrasound in Obstetrics and Gynecology (ISUOG) is a scientific organization that encourages sound clinical practice, high-quality teaching research related to diagnostic imaging women's healthcare. ISUOG Clinical Standards Committee (CSC) has remit develop Practice Guidelines Consensus Statements as educational recommendations provide healthcare practitioners with consensus-based approach, from experts, for imaging. They are intended reflect what considered by...
In female fetuses ovarian cysts represent the most important differential diagnosis for intra-abdominal masses. Analyzing our own patient population we investigated whether there was a connection between sonographic parameters and postnatal course, especially with regard to need surgical intervention.This retrospective analysis of cases from years 1986-1999. The pre- data 64 who were suspected prenatally have an cyst analyzed. outcome known all children.The made in third trimester (median,...
Abstract Objective Congenital heart defects (CHD), particularly conotruncal anomalies, may be associated with deletion of chromosome 22q11.2. Thymic aplasia or hypoplasia is known to a typical feature in this condition. We aimed establish (i) the prevalence del22q11.2 fetal CHD and (ii) whether ultrasound assessment an absent hypoplastic thymus helps preselection group who are at high risk for deletion. Study design In fetuses (> 16 weeks) CHD, karyotyping fluorescence situ hybridization...
Abstract Objectives The ratio of the lung area (on contralateral side hernia) to head circumference, lung‐to‐head (LHR), has been proposed as a reliable tool in assessment prognosis congenital diaphragmatic hernia (CDH). An LHR < 0.6 associated with poor outcome whereas one > 1.4 survival. We aimed analyze role predicting fetal and ventilation parameters cases isolated CDH our center. Methods During 40‐month study period, 22 fetuses an were delivered alive under optimized conditions at...
To establish reference ranges for the fetal thymic-thoracic ratio (TT-ratio) and to compare results with those from fetuses congenital heart defects (CHD) without microdeletion 22q11 (del.22q11), a condition known be associated hypoplastic thymus.TT-ratio was defined as quotient of anteroposterior thymic intrathoracic mediastinal diameters measured in three vessels trachea view. This prospective cross-sectional study 302 normal healthy between 15 39 weeks' gestation. The group comprised two...
We describe a case series of six fetuses with open spina bifida (OSB) from four different prenatal units, where the anomaly was detected at routine 11-13-week ultrasound examination. Crown-rump length ranged 49 to 78 mm. All cases were first suspected during nuchal translucency thickness measurement in mid-sagittal plane face. OSB lumbosacral five and cervical one. The intracranial (IT) obliterated two cases, but some fluid found other cases. However, all typical landmarks normal posterior...
The monogenic etiology of most severe fetal anomaly syndromes is poorly understood. Our objective was to use exome sequencing (ES) increase our knowledge on causal variants and novel candidate genes associated with specific phenotypes. We employed ES in a cohort 19 families one or more fetuses presenting distinctive pattern and/or phenotype recurrence at increased risk for lethal outcomes. Candidate were identified 12 (63%); 6 them definite diagnosis achieved including known recognized...
To assess the fetal cardiovascular system using three-dimensional power Doppler ultrasound (3D-PDU) in normal and abnormal conditions during second half of gestation.Forty-five fetuses 87 selected pregnancies with different abnormalities involving vascular were examined.The following regions interest assessed: placental, umbilical, abdominal, renal, pulmonary intracranial vessels together heart great arteries. Equipment used was a commercially available HDI-3000 5000 integrated 3D-Color...
Abstract Objective To describe the morphology of frontal bones and metopic suture at 9–34 weeks gestation using three‐dimensional (3D) ultrasonography. Methods This was a cross‐sectional study in 16 fetuses gestation. 3D ultrasonography used to obtain volumes whole fetal skull mid‐sagittal plane. The were analyzed rendering mode transparent maximum order achieve clear view suture. Results At 9 weeks, small ossification center visible middle each supraorbital part by 11 appeared as ‘thick...