A5090603603- Cardiovascular Function and Risk Factors
- Cardiomyopathy and Myosin Studies
- Cardiac Imaging and Diagnostics
- Congenital Heart Disease Studies
- Renal Transplantation Outcomes and Treatments
- Hemodynamic Monitoring and Therapy
- Organ Transplantation Techniques and Outcomes
- Kawasaki Disease and Coronary Complications
- Cardiovascular and exercise physiology
- Coronary Artery Anomalies
- Congenital heart defects research
- Organ Donation and Transplantation
- Galectins and Cancer Biology
- Pericarditis and Cardiac Tamponade
- Williams Syndrome Research
- Cardiac Valve Diseases and Treatments
- Cardiovascular Effects of Exercise
- Protein Tyrosine Phosphatases
- Pulmonary Hypertension Research and Treatments
- Trypanosoma species research and implications
- Transplantation: Methods and Outcomes
- Cardiac Structural Anomalies and Repair
- Peptidase Inhibition and Analysis
Children's Hospital of Philadelphia
2020-2025
University of Pennsylvania
2022-2025
Albany Medical Center Hospital
2025
Philadelphia University
2022
Pancreatic Cancer UK
1991
Background In multisystem inflammatory syndrome in children, there is paucity of longitudinal data on cardiac outcomes. We analyzed outcomes 3 to 4 months after initial presentation using echocardiography and magnetic resonance imaging. Methods Results included 60 controls cases children. Conventional echocardiograms deformation parameters were at time points: (1) acute phase (n=60), (2) subacute (n=50; median, days echocardiography), (3) 1‐month follow‐up (n=39; 22 days), (4) 3‐ 4‐month...
We hypothesized left atrial (LA) stiffness may serve as a surrogate marker in children to differentiate elevated pulmonary capillary wedge pressure (PCWP) from normal and help detect diastolic dysfunction myocardial injury due multisystem inflammatory syndrome (MIS-C).We validated LA 76 patients (median age 10.5 years), 33 had PCWP (<12 mmHg) 43 (≥12 mmHg). was applied 42 MIS-C [28 with (+) 14 without (-)], defined by serum biomarkers. The validation group consisted of cardiomyopathies,...
Abstract AimsTo simplify measurement of untwist by measuring the recoil rate LV apex only, to validate and apply peak apical (PARR) as an index diastolic dysfunction (DD) in pediatric subjects during increased decreased lusitropic states. Methods ResultsWe recruited 153 healthy (mean age 13.8 + 2.9 years), whom 48 performed straight leg raising exercise additional 46 patients 8.4 5.6 years) with documented pulmonary capillary wedge pressures (PCWP) (validation cohort). In addition, we...
Abstract Background In children with hypertrophic cardiomyopathy (HCM), the genotype-phenotype association of abnormal electrocardiographic (ECG) features in backdrop gene positivity have not been well described. This study aimed to describe ECG findings HCM harboring genetic variants and determine Major Adverse Cardiac Events (MACE). Methods We retrospectively analyzed 81 positive, phenotype positive (V+P+), 66 variant negative (V+P-), 85 non-sarcomeric subjects. clinical outcomes these...
Background: Determining risk factors by echocardiography to prevent major adverse cardiac events (MACE) is crucial in pediatric patients with hypertrophic cardiomyopathy (HCM). Recent studies have shown that LA stiffness and strain may serve as surrogate markers children, differentiate elevated pulmonary capillary wedge pressure from normal predict COVID-19 related myocardial injury. Hypothesis: MACE HCM. Methods: We retrospectively enrolled 201 HCM diagnosed echocardiography. They were...
Introduction: Three-dimensional echocardiography (3DE) has been shown to be superior two-dimensional (2DE) for the quantification of chamber volumes and dimensions. However, utility 3DE in routine clinical practice restricted by time-consuming analysis need 3D-specific training. This study aims assess accuracy Philips Dynamic Heart ModelA.I. (DHM), a “hands off” automated software program, that may used measure LA is notable, as indexed volume predictor heart failure adults. Hypothesis: We...
Introduction: Three-dimensional echocardiography (3DE) has been shown to be superior 2DE when quantifying chamber dimensions. However, the clinical utility of 3DE limited by time-consuming analysis and need for 3D-specific training. This study aims assess a “hands-off,” artificial intelligence-driven software program, Philips Dynamic HeartModelA.I. (DHM), in pediatric population. Hypothesis: We hypothesize that this program will able accurately calculate LVEF children compared Cardiac MRI...
Introduction: Fully automated strain measurements have been developed for the left ventricle. However, they not studied in right ventricle (RV) of adults or children. Hypothesis: Automated RV will be comparable with manual measurements. Methods: We prospectively enrolled 94 patients, who underwent clinically indicated echocardiograms (mean age: 13.0±4.4 years). Strain included free wall longitudinal (RVFWLS) and “global” (RVGLS), both measured from RV-focused apical 4-chamber view....
Background: Global Longitudinal Strain (GLS) is a sensitive indicator of cardiac function in children. However, GLS analysis limited by time-consuming manual tracing and interobserver variability. This study aims to assess clinical feasibility AutoStrain, “hands-off” method Hypothesis: AutoStrain will quickly accurately calculate Methods: We prospectively enrolled 168 patients, who underwent clinically indicated echocardiograms (mean age:12±4 years). parameters were measured using three...