A5079203590- Congenital Heart Disease Studies
- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Transplantation: Methods and Outcomes
- Cardiomyopathy and Myosin Studies
- Heart Failure Treatment and Management
- Cardiovascular Effects of Exercise
- Cardiovascular Function and Risk Factors
- Cardiac pacing and defibrillation studies
- Cardiac Arrest and Resuscitation
- Renal Transplantation Outcomes and Treatments
- Healthcare Policy and Management
- Pulmonary Hypertension Research and Treatments
- Viral Infections and Immunology Research
- Emergency and Acute Care Studies
- Congenital heart defects research
- Adolescent and Pediatric Healthcare
- Cardiac Valve Diseases and Treatments
- Cardiovascular Issues in Pregnancy
- Tracheal and airway disorders
- Organ Transplantation Techniques and Outcomes
- Pharmaceutical studies and practices
- Pneumonia and Respiratory Infections
- Childhood Cancer Survivors' Quality of Life
- Vascular anomalies and interventions
Children's Hospital of Philadelphia
2017-2025
University of Vermont Medical Center
2023-2025
University of Pennsylvania
2017-2024
University of Vermont
2022-2024
University of Vermont Children’s Hospital
2024
Philadelphia University
2019-2023
Hospital of the University of Pennsylvania
2020
Duke Medical Center
2010-2012
Clinical Research Institute
2010-2012
Duke University Hospital
2011
OBJECTIVE: Previous analyses have suggested center volume is associated with outcome in children undergoing heart surgery. However, data are limited regarding potential mediating factors, including the relationship of postoperative complications and mortality those who suffer a complication. We examined this association large multicenter cohort. METHODS: Children 0 to 18 years surgery at centers participating Society Thoracic Surgeons Congenital Heart Surgery Database (2006–2009) were...
Immunotherapy with chimeric antigen receptor (CAR)-modified T cells targeting CD19 for pediatric acute lymphoblastic leukemia (ALL) has demonstrated significant efficacy. The principle toxicity is cytokine release syndrome resultant hypotension. However, the spectrum of cardiovascular effects associated CAR cell therapy not been systematically evaluated. We reviewed all patients who received CD19-directed at Children's Hospital Philadelphia between April 2012 and September 2016. primary...
Recently, there has been a shift toward care of children undergoing heart surgery in dedicated pediatric cardiac intensive units (CICU). The impact this trend on patient outcomes is unclear. We evaluated postoperative associated with CICU versus other ICU models.Society Thoracic Surgeons Congenital Heart Surgery Database participants (2007-2009) who completed an survey were included. In multivariable analysis, we ICUs, adjusting for center volume, factors, and Society Surgeons-European...
Objective Limited contemporary data exist regarding outcomes and resource use among adults with congenital heart disease failure (ACHD-HF). This study compared outcomes, emergency department (ED) hospital use, advanced (HF) therapies in ACHD-HF versus non-ACHD HF (HF-non-ACHD). Methods The Nationwide Emergency Department Sample Inpatient were used to analyse ED visits hospitalisations from 2006 2016. was stratified by single-ventricle (SV) two-ventricle (2V) disease. Results A total of 76...
Limited data are available regarding contemporary models of care delivery for patients undergoing congenital heart surgery. The purpose this survey was to evaluate current US practice patterns in patient population. Cross-sectional evaluation centers caring surgery performed using an Internet-based survey. Data postoperative were collected and described overall compared with a pediatric intensive unit (PICU) versus dedicated cardiac (CICU). A total 94 (77%) the estimated 122 performing...
Treatment of adult congenital heart disease patients who require advanced therapies remains challenging due to high perioperative and wait-list mortality limited donors. Patients palliated with Fontan are at the highest risk early multiorgan involvement few centers able safely transplant them. We sought evaluate outcomes transplants in these patients.Using Nationwide Inpatient Sample database, we identified all adults aged least 18 years old underwent transplantation across U.S. hospitals...
Background The physiologic hallmarks of the Fontan circulation-chronically elevated central venous pressures and low cardiac output-have significant effects not only on cardiovascular status but also impact other organ systems. Exercise capacity is limited in many declines with age, accelerating adolescence, wide variability. We explore relationship between exercise performance end-organ function outpatient subjects a circulation. Methods Results This cross-sectional analysis subject...
Background Children with Down syndrome (DS) have a high risk of cardiac disease that may prompt consideration for heart transplantation (HTx). However, in patients DS is rarely reported. This project aimed to collect and describe waitlist post- HTx outcomes children DS. Methods Results retrospective case series listed HTx. Pediatric centers were identified by their participation 2 international registries reporting patient providing detailed demographic, medical, surgical, posttransplant...
Abstract Limited data exist to guide exercise participation in pediatric hypertrophic cardiomyopathy (HCM) patients. Exercise is traditionally restricted this population, despite research adults with HCM demonstrating exercise-associated cardiovascular and psychological benefit. This pilot study seeks assesses the safety feasibility of a moderate-intensity program children future design. Eight subjects ages 8–18 were recruited from outpatient cardiology clinic at large tertiary care referral...
We evaluated the setting of published studies conducted under US Pediatric Exclusivity Provision, which provides economic incentives to pharmaceutical companies conduct drug with children.
Data routinely collected through United Network for Organ Sharing (UNOS) lack the detailed information on medical resource utilization and treatment costs required to accomplish center-level comparisons of quality care cost pediatric heart transplantation. We aimed overcome this limitation by merging UNOS with Pediatric Health Information System (PHIS) database, an administrative database containing inpatient, emergency department, ambulatory surgery, observation unit from over 40...
Exercise stress testing (EST) in pediatric hypertrophic cardiomyopathy (HCM) patients has not well described a large heterogenous cohort. The objective of the study was to determine clinical utility EST HCM. This retrospective single-center analysis HCM younger than 21 years who had between January 1, 2000, and 2019. Clinical, demographic characteristics, data were analyzed, using last during or prior event subjects with primary outcome. composite endpoint included cardiac death, transplant,...