A5004075571- Cardiovascular Function and Risk Factors
- Congenital Heart Disease Studies
- Cardiomyopathy and Myosin Studies
- Cardiac Valve Diseases and Treatments
- Pulmonary Hypertension Research and Treatments
- Cardiac Ischemia and Reperfusion
- Cardiac Imaging and Diagnostics
- Cardiac Arrhythmias and Treatments
- Coronary Artery Anomalies
- Cardiovascular and Diving-Related Complications
- Cardiac Structural Anomalies and Repair
- Cardiovascular Effects of Exercise
- Congenital heart defects research
- Cardiovascular Issues in Pregnancy
- Anesthesia and Neurotoxicity Research
- Kawasaki Disease and Coronary Complications
- Neurogenetic and Muscular Disorders Research
- Aortic Disease and Treatment Approaches
- Vascular anomalies and interventions
- Cardiac tumors and thrombi
- Cardiovascular and exercise physiology
- Cardiac Arrest and Resuscitation
- Elasticity and Material Modeling
- Cardiac electrophysiology and arrhythmias
- Sarcoma Diagnosis and Treatment
Children's Hospital of Philadelphia
2015-2025
University of Pennsylvania
2014-2025
Vellore Institute of Technology University
2025
Philadelphia University
2020-2024
University of Trieste
2020
SUNY Downstate Health Sciences University
2019
George Washington University
2016
Army Hospital Research and Referral
2016
University of Colorado Denver
1991-2015
University of Colorado Anschutz Medical Campus
1997-2015
Polymorphonuclear neutrophils (PMNs) play a pivotal role in the inflammation that precedes multiple organ failure (MOF). In rat model of MOF, PMNs become primed for enhanced superoxide anion (Osub 2 sup - ) release and CD11b expression, sequester end organs, produce failure. Therefore, we hypothesized circulating harvested first 24 hours after injury from trauma patients at risk MOF would (1) exhibit Osub release, (2) upregulate (3) show evidence sequestration tissues. Extracellular PMN...
Background In multisystem inflammatory syndrome in children, there is paucity of longitudinal data on cardiac outcomes. We analyzed outcomes 3 to 4 months after initial presentation using echocardiography and magnetic resonance imaging. Methods Results included 60 controls cases children. Conventional echocardiograms deformation parameters were at time points: (1) acute phase (n=60), (2) subacute (n=50; median, days echocardiography), (3) 1‐month follow‐up (n=39; 22 days), (4) 3‐ 4‐month...
In clinical practice, point-of-care diagnostic testing has progressed rapidly in the last decade. For field of wound care, there is a compelling need to develop rapid alternatives for bacterial identification setting, where it generally takes over 24 hours receive positive identification. Even new molecular and biochemical methods require an initial incubation period several obtain sufficient number cells prior performing analysis. Here we report use inexpensive, disposable electrochemical...
Background: Controversy still exists regarding closure of atrial septal defects (ASDs) in patients >40 years age who are largely asymptomatic or do not have large shunts (LS). If left unrepaired, the majority will experience symptoms and a shorter life span compared to undergo repair. This study presents outcomes ASDs adults using Amplatzer occluder. Methods: A total 113 (79F/34M) with mean 57.9 (SD 11.9) had indications for (right ventricular [RV] enlargement by echocardiograpy,...
Hidradenitis suppurativa (HS) is a chronic recurrent inflammatory disease of apocrine glands which affects 1–4% young adults. The purpose this study was to investigate cytokines in effluent from HS lesions and identify potential local drivers inflammation HS. Wound fluid specimens patients (n = 8) age-matched wound were selected for analysis. hidradenitis score (HSS) used determine the extent activity. Cytokine analysis conducted using Meso Scale Discovery cytokine proinflammatory panels....
Abstract Background Principal strain (PS)-analysis using three-dimensional speckle-tracking echocardiography enables us to simultaneously measure 3D-ventricular volumes and strains. PS quantifies 3D-deformation by defining not only amplitude but also direction of principal myocardial contraction (PS-angle). Objectives 1) To validate volumetric functional parameters PS-analysis in volume-overloaded RV repaired-tetralogy Fallot (rTOF) versus cardiac magnetic resonance (CMR), 2) describe...
Background:Right ventricular (RV) volumetric and functional assessments are both crucial for the management of patients with hypoplastic left heart syndrome (HLHS). 3-dimensional echocardiography (3DE) volume measurements 2D speckle-tracking (2D-STE) strain analysis performed separately. 3D-STE is capable evaluating those parameters simultaneously providing principal (PS), unifying concepts myofiber orientation contraction into a single, maximal contractile direction. However, application to...
Background Cardiac dysfunction is a prominent feature of multisystem inflammatory syndrome in children (MIS-C), yet the etiology poorly understood. We determined whether global or regional, and it associated with cytokine milieu, microangiopathy, severity shock. Methods Results analyzed echocardiographic parameters myocardial deformation compared segmental left ventricular strain between 43 cases MIS-C ≤18 years old 40 controls. Primary outcomes included longitudinal strain, right free wall...
We hypothesized left atrial (LA) stiffness may serve as a surrogate marker in children to differentiate elevated pulmonary capillary wedge pressure (PCWP) from normal and help detect diastolic dysfunction myocardial injury due multisystem inflammatory syndrome (MIS-C).We validated LA 76 patients (median age 10.5 years), 33 had PCWP (<12 mmHg) 43 (≥12 mmHg). was applied 42 MIS-C [28 with (+) 14 without (-)], defined by serum biomarkers. The validation group consisted of cardiomyopathies,...