A5031483187- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Renal cell carcinoma treatment
- Immune cells in cancer
- Lymphoma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- Urinary and Genital Oncology Studies
- Vascular Tumors and Angiosarcomas
- Bladder and Urothelial Cancer Treatments
- Urologic and reproductive health conditions
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Adrenal and Paraganglionic Tumors
- Epigenetics and DNA Methylation
- Breast Cancer Treatment Studies
- Brain Metastases and Treatment
- Soft tissue tumor case studies
- TGF-β signaling in diseases
- Viral-associated cancers and disorders
- Bone Metabolism and Diseases
- Pancreatic and Hepatic Oncology Research
- Cancer Cells and Metastasis
- Breast Lesions and Carcinomas
Mongolian National University of Medical Sciences
2020-2024
Mongolian National University
2020-2023
Dokkyo Medical University
2018-2021
Abstract Tumor-associated macrophages (TAMs) have recently been reported as an important factor in tumor growth and the progression of cancer. The prognostic significance localizations densities TAMs triple negative cancer (TNC) breast is not well understood. aim this study was to assess subtype TNC examine their clinicopathological features. based on 107 cases operated at Dokkyo Medical University Hospital using pan-macrophage marker CD68 M2 macrophage CD163 stroma (TS) nest (TN),...
Recent investigations have demonstrated that the tumor microenvironment, including tumor-infiltrating lymphocytes (TILs), is an important factor in growth and development. While prognostic correlation of T cells has been widely studied breast cancer, B plasma not received so much attention, especially triple-negative cancer (TNBC).We investigated 114 patients with TNBC who had surgery between 2006 2019 at Dokkyo Medical University Hospital. Intratumoral (i) TILs were considered to be within...
Immune cells such as cytotoxic T cells, helper B or tumor-associated macrophages (TAMs) contribute to the anti-tumor response pro-tumorigenic effect in triple negative breast cancer (TNBC). The interrelation of TAMs, and tumor-infiltrating lymphocytes (TILs) TNBC has not been fully elucidated.
Abstract Background In this study, we investigated CD20+ TILs in triple-negative breast cancer (TNBC) and their relationship with T lymphocyte subsets (CD4+, CD8+, CD25+, FOXP3+), including combined prognostic value using an immunohistochemical staining method. Methods We 107 patients TNBC for whom a full-face section stained by hematoxylin eosin between 2006 2018 at Dokkyo Medical University Hospital was available. Results The strongest association of infiltrating CD4+ TILs. There...
Abstract Background Tumor-infiltrating lymphocytes (TILs) have recently been reported as an important factor in the tumor microenvironment and influence growth progression of cancer. However, relationship between immune cell subpopulations, such CD4+, CD8+, FOXP3+, breast cancer, especially triple negative carcinoma (TNC), remains unclear. Methods The subjects were 107 patients with TNC that surgically resected at Dokkyo Medical University Hospital 2006 2018. expression FOXP3+ was evaluated...
Abstract Background The clinical relevance of pancreatic intraepithelial neoplasia (PanIN) at the resection margin ductal adenocarcinoma remains unknown. We aimed to investigate its impact transection (PTM) and, based on result, determine prognostic values status and other clinicopathologic parameters. Patients methods retrospectively analyzed 122 consecutive patients who underwent pancreatoduodenectomy or distal pancreatectomy between 2006 2018. Pathologic slides were reviewed survival data...
Abstract Succinate dehydrogenase (SDH)‐deficient renal cell carcinoma (RCC) is mainly associated with a mutation in the SDHB gene and sometimes mutations SDHC or SDHD genes. However, only three cases of succinate A (SDHA)‐deficient RCC have been reported, relation between SDHA has not clarified. This study assessed role human RCC. We investigated SDHA/B/C/D 129 RCCs. Targeted next‐generation sequencing direct Sanger revealed single nucleotide variants (SNVs) amino acid sequence variations...
Recently, an in situ hybridization (ISH) and immunohistochemical study demonstrated that Epstein-Barr virus (EBV) infection may be involved tonsillar hypertrophy recurrent tonsillitis children young adolescents. The present was based on 630 consecutive specimens from tonsillectomies performed at the Dokkyo University School of Medicine between 2002 May 2017. Clinical findings were obtained hospital records. Histologically, a "pale clear zone" characterized by hyperplastic germinal centers...
Abstract Aim To establish the histological categorization of tumor‑associated stroma (TAS) that reflects biological behavior triple-negative breast cancer (TNBC). Methods and results One-hundred-and-twenty surgically resected cases TNBC were examined. We histologically categorized TAS in invasive frontal region into two groups: mature (MS) immature (IS). The designation IS was applied for tumors which largest myxoid filled a high-power magnification field. When there no meet criteria IS, as...
BACKGROUND:Primary hepatic angioleiomyoma is a rare mesenchymal tumor that characterized by blood vessels and smooth muscle. Herein, we report an extremely case of primary discuss the clinicopathological features. CASE REPORT:A 60-year-old Mongolian man was diagnosed with in second third segments screening 2012. It had been under control physician for 10 years. The patient discomfort vague pain right side abdomen since April 2022. Hepatitis virus markers (hepatitis B hepatitis C) were...
BACKGROUND Gastric adenocarcinoma of the fundic gland type (GAFG) is an extremely rare neoplasm that consists a mixed proliferation oxyntic and chief cells. Differential diagnosis GAFG difficult in absence infiltration. Here, we report case discuss clinicopathological features. CASE REPORT A 78-year-old man was diagnosed with gastritis reflux esophagitis, status after esophagectomy for carcinoma esophagus 2015. The patient underwent repeated gastric biopsies 2017 atypical epithelium...
Breast carcinoma with osteoclast-like giant cells (OGCs) is extremely rare. OGCs are found mostly in invasive breast and ductal situ We report a case of the (DCIS OGCs) 38-year-old female. Histologically, on low-power view, DCIS exhibited solid pattern thick fibrovascular stroma. On high-power tumor showed indistinct eosinophilic cytoplasm, round to oval nuclei prominent nucleoli. Most were identified within space formed by consisted multiple abundant cytoplasm. Immunohistochemically, p63...
Abstract Background The tumor transformation mechanism of a plasmacytoid urothelial carcinoma remains unexplained. We describe the case renal pelvis in which expression zinc finger E–box–binding homeobox 1 (ZEB1), key nuclear transcription factor an epithelial–mesenchymal transition, is involved transformation. Case presentation patient had left nephrectomy with clinical diagnosis pelvic cancer. resected specimen showed that surface comprised noninvasive papillary situ, and invasive area...