A5112310086- Myasthenia Gravis and Thymoma
- Acute Myeloid Leukemia Research
- Immunotherapy and Immune Responses
- Lymphoma Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Medical Imaging and Pathology Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Hematological disorders and diagnostics
- Viral-associated cancers and disorders
- Testicular diseases and treatments
- Drug Transport and Resistance Mechanisms
- Immune Cell Function and Interaction
- Tuberculosis Research and Epidemiology
- Blood disorders and treatments
- Cancer Immunotherapy and Biomarkers
- T-cell and B-cell Immunology
- Vascular Tumors and Angiosarcomas
- Cancer Diagnosis and Treatment
- Histiocytic Disorders and Treatments
- Renal and related cancers
- Colorectal and Anal Carcinomas
- Glycosylation and Glycoproteins Research
- Meningioma and schwannoma management
- Sarcoma Diagnosis and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Tokyo Women's Medical University Adachi Medical Center
2018-2025
Kanagawa Prefectural Hospital Organization
2025
Kanagawa Cancer Center
2024-2025
Tokyo Women's Medical University
2017-2018
Tokyo Women's Medical University Yachiyo Medical Center
2017-2018
Showa University Northern Yokohama Hospital
2017
Showa University Fujigaoka Hospital
2003-2014
Showa University
2007-2014
Japan Pediatric Society
2008
The University of Tokyo
1990-2002
Abstract Many mechanisms involving TNF-α, Th1 responses, and Th17 responses are implicated in chronic inflammatory autoimmune disease. Recently, the clinical impact of anti-TNF therapy on disease progression has resulted re-evaluation central role this cytokine engendered novel concept TNF-dependent immunity. However, overall relationship TNF-α to pathogenesis is unclear. Here, we demonstrate a differentiation pathway dendritic cells (DC) evoking responses. CD14+ monocytes cultured presence...
Recent investigations have demonstrated that the tumor microenvironment, including tumor-infiltrating lymphocytes (TILs), is an important factor in growth and development. While prognostic correlation of T cells has been widely studied breast cancer, B plasma not received so much attention, especially triple-negative cancer (TNBC).We investigated 114 patients with TNBC who had surgery between 2006 2019 at Dokkyo Medical University Hospital. Intratumoral (i) TILs were considered to be within...
Abstract Background In this study, we investigated CD20+ TILs in triple-negative breast cancer (TNBC) and their relationship with T lymphocyte subsets (CD4+, CD8+, CD25+, FOXP3+), including combined prognostic value using an immunohistochemical staining method. Methods We 107 patients TNBC for whom a full-face section stained by hematoxylin eosin between 2006 2018 at Dokkyo Medical University Hospital was available. Results The strongest association of infiltrating CD4+ TILs. There...
Low-grade oncocytic tumor (LOT) of the kidney is an emerging entity among renal tumors. While histological features LOT are similar to those oncocytoma, immunohistochemically expresses keratin 7 (KRT7) but not KIT while oncocytoma KIT. Molecular analyses LOTs using next generation sequencing revealed tumors harbor mutations mTOR-related genes. An 80-year-old Japanese man with a history clear cell carcinoma and prostatic cancer underwent resection right kidney, 10 mm in diameter, which was...
This study analysed 65 children who were prospectively registered between 1999 and 2008 fulfilled the World Health Organization criteria of refractory cytopenia childhood (RCC). First-line therapy was determined by treating physicians: 25 patients received immunosuppressive (IST), 12 haematopoietic stem cell transplantation (HSCT) one patient intensive chemotherapy. The remaining 27 followed without treatment for more than 2 years (watch wait; WW). In WW group, 18 had stable disease further...
The expression of multidrug-resistance-associated protein (MRP) was assessed in various types untreated lung cancer using an immunohistochemical technique. MRP abundantly expressed 28 59 adenocarcinoma specimens (47%) and its associated with the degree glandular differentiation tumor. well-differentiated adenocarcinomas (56%) higher than poorly differentiated (22%) (p < 0.01). lower--20% squamous-cell carcinomas, 20% large-cell carcinomas 0% small-cell carcinoids. RT-PCR showed that...
Summary Juvenile myelomonocytic leukaemia ( JMML ) is a rare haematopoietic stem cell disease of early childhood, which can progress to blast crisis in some children. A total 153 children diagnosed with were reported the Myelodysplastic Syndrome Committee Japan between 1989 and 2007; 15 them (9·8%) had 20% or more blasts bone marrow (blast crisis) during course. Blast occurred observation without therapy n = 3) oral 6‐mercaptopurine treatment 9) relapse after transplantation HSCT ; 3). Six...
Abstract Pulmonary alveolar proteinosis (PAP) is a heterogeneous disease that occasionally develops with hematological malignancy. However, PAP in association hematopoietic stem cell transplantation quite rare. Here we present the first report of patient who developed after cord blood (CBT). A 45‐year‐old female AML underwent unrelated CBT. On day +2 CBT she congestive heart failure diffuse infiltrates bilateral lungs. Despite treatment, further increased progression multiple organ (MOF)....
In order to study the frequency of secondary infections AIDS autopsy cases in Japan, especially Mycobacterium aviumintracellulare complex (MAC) infection, retrospective was conducted between 1986 and 1997 at affiliated hospital Institute Medical Sciences, University Tokyo. Secondary various organs from 43 were examined using histopathology, genetic diagnosis tuberculosis, Ziehl-Neelsen stain for acid-fast bacilli immunohistochemistry. Nontuberculous mycobacterial infection (Mycobacterium...
Two autopsy cases of fulminant‐type infection associated with necrotizing fasciitis were analyzed clinicopathologically. Both involved 57‐year‐old alcohol abusers. The former was a woman group A (beta) hemolytic Streptococcus pyogenes infection, and the latter man Vibrio vulnificus infection. sudden onset shock high fever resulted in sepsis, decreased clotting, hepatorenal symptoms, followed by death within few days. Post‐mortem examination showed widespread congestion bleeding, alcoholic...
To assist physicians, especially young in identifying tuberculosis (TB) infection before the terminal stage, we analyzed 7 cases of numerous tuberculous granulomas multiple organs and compared clinical autopsy findings between cases. Patients ranged age from 41 to 86 years at time death. The main chief complaint was fever unknown origin (3 [43%]). underlying conditions were liver cirrhosis (2 [29%]) chronic renal failure [29%]). Two patients (29%) had been given methylprednisolone pulse...
A report is presented of a follicular dendritlc cell (FDC) tumor arising In the lymph nodes and Inguen 55‐year‐old Japanese female, who had suffered from schizophrenla for 25 years. The left submandibular completely lost their normal architecture, except capsule, due to infiltration. Occaslonal nodular structures resembling epltheliold granulomas, attributable, at least part, Involvement cells, were observed. These nodules composed epithellold‐ or fibroblast‐like cells forming interwoven...
Reported herein are three autopsy cases of fulminant‐type pneumococcal sepsis with disseminated intravascular coagulation (DIC) resulting in death within a few days onset symptoms. Two the patients had previously splenectomy because hematological disorder. None received vaccination. On post‐mortem every organ congestion as well bleeding. Interestingly, severe inflammation alveoli was absent despite sepsis. The cause rapidly progressive leading to DIC and circulatory failure, which appeared...
In a number of human malignancies, tumor-associated macrophages (TAMs) are closely involved in tumor progression. On the other hand, dendritic cells (DCs) that infiltrate tissues suppression. However, there have been very few reports on distribution profiles TAMs and DCs thymic epithelial tumors. We examined difference between thymoma carcinoma. 69 samples surgically resected tumors, namely, 16 carcinomas 53 thymomas, which we immunohistochemically evaluated presence using CD68 CD163 as...
IgG4-related disease often forms a mass and the affected lesion is clinically removed because cannot be differentiated from neoplasm. Affected lesions commonly occur in pancreas, hepatobiliary tract, kidney, retroperitoneum. However, rarely occurs thymus. A histological worldwide consensus of proposed that pathological diagnosis should meet more than two three major features: 1) dense lymphoplasmacytic infiltration with greater 40% IgG4+/IgG+ plasma cells, 2) storiform fibrosis; 3)...
Mutation or promoter methylation of the phosphatase tensin homologue deleted on chromosome 10 tumour suppressor gene (PTEN) promotes some cancers. Moreover, PTENP1 (PTEN pseudogene) transcript regulates PTEN expression and is thought to be associated with tumourigenesis in Here, we investigated thymic epithelium epithelial tumours.Immunohistochemical analysis was performed two non-tumourous thymus (NT) samples, 33 thymomas (three type A, eight AB, 11 B1, six B2, five B3), four carcinomas...
We experienced a case of neuroendocrine carcinoma ( NC ). The tumor developed in the cirrhotic liver 62‐year‐old Japanese man who had been infected with hepatitis C virus. cells showed high N / ratio, formed many rosettes, and expressed CD 56, synaptophysin, H ep P ar1 pancreatic duodenal homeobox 1. MIB 1 expression was 65%. Because both pancreas are derived from common endodermal layer during fetal development, we speculated that may have via interaction neurogenin 3, insulinoma‐associated...
Summary A uterine CD8-positive. HTLV-1-negative T-cell lymphoma associated with atypical endometrial hyperplasia was found in a 63-year-old Japanese woman. Primary of the uterus has not been previously reported.