A5021986578- Asthma and respiratory diseases
- Acute Myeloid Leukemia Research
- Immune Cell Function and Interaction
- Acute Lymphoblastic Leukemia research
- IL-33, ST2, and ILC Pathways
- Hematological disorders and diagnostics
- Blood disorders and treatments
- Cardiac and Coronary Surgery Techniques
- Pneumocystis jirovecii pneumonia detection and treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Neonatal Respiratory Health Research
- Asymmetric Synthesis and Catalysis
- Chronic Lymphocytic Leukemia Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- T-cell and B-cell Immunology
- Polymer Synthesis and Characterization
- Childhood Cancer Survivors' Quality of Life
- Antifungal resistance and susceptibility
- Oxidative Organic Chemistry Reactions
- HIV Research and Treatment
- Chemical Synthesis and Analysis
- Ginkgo biloba and Cashew Applications
- Nursing Diagnosis and Documentation
- Galectins and Cancer Biology
- Aortic Disease and Treatment Approaches
Tokyo National Hospital
2021-2025
The University of Tokyo
2021-2025
Keio University
2011-2024
St. Luke's International Hospital
2008-2014
Kitasato University
1972-2011
Kyushu University
1992-1993
Chiba University
1990
This study analysed 65 children who were prospectively registered between 1999 and 2008 fulfilled the World Health Organization criteria of refractory cytopenia childhood (RCC). First-line therapy was determined by treating physicians: 25 patients received immunosuppressive (IST), 12 haematopoietic stem cell transplantation (HSCT) one patient intensive chemotherapy. The remaining 27 followed without treatment for more than 2 years (watch wait; WW). In WW group, 18 had stable disease further...
A subgroup of patients with chronic pulmonary aspergillosis (CPA) exhibits elevated serum total immunoglobulin E (IgE) levels, similar to allergic bronchopulmonary aspergillosis; however, the underlying mechanisms remain unclear. This study aimed clarify pathophysiology CPA high IgE levels. In this study, we prospectively collected cases treated at our hospital between January and July 2022 measured cytokine levels along clinical data. We compared 34 healthy controls (HCs) 51 found...
High serum total immunoglobulin E (IgE) levels have been reported in chronic pulmonary aspergillosis (CPA). However, researchers not verified if they reflect the disease activity. We aimed to compare IgE CPA cases with high during an exacerbation or when stable and examined expression patterns lesions via immunofluorescence staining. From April 2016 September 2019, we extracted elevated based on criteria of Infectious Diseases Society America. retrospectively analyzed other parameters...
The influence of central nervous system (CNS)-directed chemotherapy on intelligence remains controversial. In this study, we investigated the treatment intellectual development in acute lymphoblastic leukemia (ALL) and brain tumor patients undergoing CNS-directed treatments.Among treated Department Pediatrics, St Luke's International Hospital between April 2000 March 2009, subjects were 38 with ALL or tumors who underwent regular Wechsler tests.The consisted 26 12 tumors. Prophylactic...
Objective: Benralizumab, a humanized monoclonal antibody against human IL-5 receptor alpha, is effective in treating eosinophilic severe asthma. However, patients' response to benralizumab varies widely. In this study, we aimed identify new serum biomarker accurately predict response.Methods: Seventeen benralizumab-treated patients with asthma were enrolled. Blood samples collected; pulmonary function tests performed and questionnaires disseminated at baseline after 1, 2, 4, 6 months of...
Recently, fatty acid esters synthesized from the natural oil obtained plants have attracted much attention as an insulating viewpoint of environmental problems, fluidity, and greater resistance to dielectric breakdown than conventional mineral oil. In present study, clarify reason for superior moisture tolerance esters, inter- intramolecular movements situation dissolved water in are investigated using nuclear magnetic resonance (NMR) infrared (IR) spectroscopic measurements density...
Abstract Secretory immunoglobulin A plays an important role in the protection against exogenous pathogens and antigens, but it has also been reported to have pathogenic potential. We previously found that secretory accumulated peripheral lungs during idiopathic pulmonary fibrosis transferrin receptor/CD71 was partially involved A-induced inflammatory cytokine production A549 cells. This study aimed identify receptor responsible for induction of by A-stimulated airway epithelial To this end,...
Objective Dupilumab, a monoclonal antibody specific for the human interleukin (IL)-4 receptor α, is used to treat severe asthma, especially in patients with elevated blood eosinophil counts and fractional exhaled nitric oxide (FeNO). The therapeutic response dupilumab highly variable. In this study, we explored new serum biomarkers accurately predict effect of examine based on changes clinical parameters cytokine levels. Methods Seventeen asthma treated were enrolled. Responders, defined as...
Abstract Tri‐, tetra‐ and pentaethyleneglycol monochlorides were prepared from ethylene oxide chlorohydrin in the presence of sulfuric acid. Decyl, dodecyl tetradecyl alcohols nonylphenol reacted with above to produce monoethers which then condensed again give corresponding alkyl nonylphenyl hexa‐ nonaethyleneglycol. Their characteristics on thin layer chromatography mentioned.
Immunoglobulin A (IgA) is important in biological defense mainly the mucosal area and has pathogenic inflammatory roles various diseases. IgA activates not only but also structural cells including airway epithelial fibroblasts. The current study aimed to validate effect of on bronchial smooth muscle (BSMCs), which are another type cell involved remodeling responsiveness. Results showed that monomeric (mIgA) induced interleukin (IL)-6, IL-8, monocyte chemoattractant protein (MCP)-1...
Immunoglobulin A (IgA) is suggested to have pathogenic effects in respiratory inflammatory diseases, including asthma. We aimed analyze the relationship between serum IgA, and clinical indicators biomarkers of
This study delves into the impact of Information Technology (IT) on nursing practice in Japan, focusing patient safety within 2021-2022 Japanese Medical Accident Report Data. The research aims to understand how IT factors contribute nursing-related medical incidents a healthcare landscape rapidly integrating IT. identifies IT-related through retrospective analysis incident reports, primarily nursing, by analyzing categorized data and free-text descriptions for keywords. findings indicate...
Abstract Durch Reaktion des Na‐Salzes hydrierten Cardanols mit verschiedenen Hydroxyalkylchlorhydrinäthern, die durch Umsetzung von Epichlorhydrin den entsprechenden Glykolen hergestellt wurden, konnten einige Hydroxyalkylglyceryldiäther sowie deren Diester synthetisiert werden.