A5043694275- Schizophrenia research and treatment
- Genetic Associations and Epidemiology
- Mental Health Research Topics
- Attention Deficit Hyperactivity Disorder
- Functional Brain Connectivity Studies
- Bipolar Disorder and Treatment
- Neural and Behavioral Psychology Studies
- Mental Health and Psychiatry
- Machine Learning in Healthcare
- Transcranial Magnetic Stimulation Studies
- Psychotherapy Techniques and Applications
- Aging and Gerontology Research
- Frailty in Older Adults
- Acupuncture Treatment Research Studies
- Gastrointestinal motility and disorders
- Health disparities and outcomes
- Health and Well-being Studies
- Healthcare Systems and Public Health
- Complementary and Alternative Medicine Studies
- Genetics and Neurodevelopmental Disorders
- Tryptophan and brain disorders
- Chronic Disease Management Strategies
- Genomics and Rare Diseases
King's College London
2015-2022
University of Wolverhampton
2022
King's College Hospital
2020
Abstract Background Transcranial direct current stimulation (tDCS) could be a side-effect-free alternative to psychostimulants in attention-deficit/hyperactivity disorder (ADHD). Although there is limited evidence for clinical and cognitive effects, most studies were small, single-session stimulated left dorsolateral prefrontal cortex (dlPFC). No sham-controlled study has the right inferior frontal (rIFC), which consistently under-functioning region ADHD, with multiple anodal-tDCS sessions...
Objective: Functional MRI neurofeedback (fMRI-NF) could potentially be a novel, safe nonpharmacological treatment for attention deficit hyperactivity disorder (ADHD). A proof-of-concept randomized controlled trial of fMRI-NF the right inferior frontal cortex (rIFC), compared to an active control condition, showed promising improvement ADHD symptoms (albeit in both groups) and brain function. However, comparison with placebo condition larger is required test efficacy. Methods: This...
Our aim was to, firstly, identify characteristics at first-episode of psychosis that are associated with later antipsychotic treatment resistance (TR) and, secondly, to develop a parsimonious prediction model for TR.
Randomised controlled trials (RCTs) have shown the efficacy of CBTp, however, few studies considered its long-term effectiveness in routine services. This study reports outcomes clients seen a psychological therapies clinic, set up following positive results obtained from an RCT (Peters et al., 2010). The aims were to evaluate using data service's assessments for consecutive referrals over 12 years period, and assess whether gains maintained at 6+ months' follow-up. Of 476 consenting...
Background A recent randomised controlled trial (RCT) of acupuncture as a treatment for irritable bowel syndrome (IBS) demonstrated sustained benefits over period 12 months post-randomisation. Aim To extend the follow-up to evaluate effects at 24 Methods Patients in primary care with ongoing IBS were recruited two-arm pragmatic RCT IBS. Participants offer up 10 weekly sessions plus usual (n=116 patients) or continue alone (n=117). The outcome was self-reported symptom severity score (IBS...
Objectives To develop a prognostic tool of treatment resistant schizophrenia (TRS) in large and diverse clinical cohort, with comprehensive coverage patients using mental health services four London boroughs. Methods We used the Least Absolute Shrinkage Selection Operator (LASSO) for time-to-event data, to risk prediction model from first antipsychotic prescription development TRS, data electronic records. Results reviewed records 1,515 spectrum disorder observed that 253 (17%) developed...
Abstract Background In increasingly ageing populations, there is an emergent need to develop a robust prediction model for estimating individual absolute risk all-cause mortality, so that relevant assessments and interventions can be targeted appropriately. The objective of the study was derive, evaluate validate (internally externally) allowing rapid estimations mortality in following 10 years. Methods For development, data came from English Longitudinal Study Ageing study, which comprised...
ABSTRACT Background Transcranial direct current stimulation (tDCS) could be a side-effect free alternative to psychostimulants in Attention-Deficit/Hyperactivity Disorder (ADHD). Although there is limited evidence for clinical and cognitive effects, most studies were small, single-session, stimulated left dorsolateral prefrontal cortex (dlPFC). No sham-controlled study has right inferior frontal (rIFC), which the consistently under-functioning region ADHD, with multiple sessions of anodal...
Background: A proportion of people with treatment-resistant schizophrenia fail to show improvement on clozapine treatment. Knowledge the sociodemographic and clinical factors predicting response may be useful in developing personalised approaches Methods: This retrospective cohort study used data from electronic health records South London Maudsley (SLaM) hospital between 2007 2011. Using Least Absolute Shrinkage Selection Operator (LASSO) regression statistical learning approach, we...
Background: There is evidence of heterogeneity within treatment-resistant schizophrenia (TRS), with some people not responding to antipsychotic treatment from illness onset and others becoming after an initial response period. These groups may have different aetiologies. Aim: This study investigates sociodemographic clinical correlates early TRS. Method: Employing a retrospective cohort design, we do secondary analysis data TRS attending the South London Maudsley. Regression analyses were...
Within clinical services, there can be a delay of years before patients with psychosis, who do not respond to antipsychotic medication, receive diagnosis treatment resistant schizophrenia (TRS). There is need identify these earlier within the course their illness and expedite access specialist treatment. The aim this project was use data, available when first present predict TRS. We used existing prospective first-episode psychosis studies from across Europe (STRATA-G Consortium; N=2274,...
Cognitive deficits are common in people with schizophrenia and have a negative impact on functioning. Remediation (CR) is an effective approach to reduce the burden of cognitive difficulties however there individual differences therapy response. Previous research suggests that participants age may be significant moderator efficacy but results inconclusive. This study attempts fill this gap by exploring how influence CR outcomes. Data from ten trials NIMH Database Training Studies (DoCTRS)...
<h3>Background</h3> Although we embarked on the era of global increase in ageing population, recent declines life expectancy simultaneously experienced by many high-income countries highlight a need for an accurate prediction model estimating individual, rather than average, risk mortality older adults, based readily accessible information about individuals' lives, health and environment. Using advanced computer intensive statistical learning methods, derived, evaluated validated 10-year...