A5011711637- Neuroinflammation and Neurodegeneration Mechanisms
- Inflammasome and immune disorders
- Alzheimer's disease research and treatments
- Neuroscience and Neuropharmacology Research
- Cannabis and Cannabinoid Research
- Advanced Glycation End Products research
- Neurogenesis and neuroplasticity mechanisms
- Coconut Research and Applications
- Barrier Structure and Function Studies
- Neurotransmitter Receptor Influence on Behavior
- interferon and immune responses
- Medicinal Plant Research
- Neuroendocrine regulation and behavior
- Sphingolipid Metabolism and Signaling
- Tryptophan and brain disorders
- Zebrafish Biomedical Research Applications
- Circadian rhythm and melatonin
- Adenosine and Purinergic Signaling
- Dementia and Cognitive Impairment Research
- Retinoids in leukemia and cellular processes
- Natural product bioactivities and synthesis
- Stress Responses and Cortisol
- Curcumin's Biomedical Applications
- Fatty Acid Research and Health
German Center for Neurodegenerative Diseases
2021-2024
University of Bonn
2021-2024
University Hospital Bonn
2021-2023
SRM Institute of Science and Technology
2019
SRM University
2017-2019
Abstract Background Neuroinflammation constitutes a pathological hallmark of Alzheimer’s disease (AD). Still, it remains unresolved if peripheral inflammatory markers can be utilized for research purposes similar to blood-based beta-amyloid and neurodegeneration measures. We investigated experimental inflammation in serum analyzed interrelations towards AD pathology features cohort with focus on at-risk stages AD. Methods Data 74 healthy controls (HC), 99 subjective cognitive decline (SCD),...
Abstract Neuroinflammation is a hallmark of Alzheimer’s disease (AD) and both positive negative associations individual inflammation-related markers with brain structure cognitive function have been described. We aimed to identify inflammatory signatures CSF immune-related that relate changes cognition across the clinical spectrum ranging from normal aging AD. A panel 16 markers, Aβ42/40 p-tau181 were measured in at baseline DZNE DELCODE cohort ( n = 295); longitudinal observational study...
The tight regulation of microglia activity is key for precise responses to potential threats, while uncontrolled and exacerbated microglial neurotoxic. Microglial toll-like receptors (TLRs) are indispensable sensing different types assaults triggering an innate immune response. Cannabinoid receptor 2 (CB2) signaling a pathway control homeostasis activation, its activation connected changes in activity. We aimed investigate how CB2 impacts TLR-mediated activation. Here, we demonstrate that...
Abstract Approximately ten million people are diagnosed with dementia annually since they experience difficulties memory and thinking skills. Since neurodegenerative diseases late, most of them difficult to treat. This is due the increased severity disease during progression when neuroinflammation plays a critical role. The activation immune cells, especially microglia, crucial role in development diseases. Molecular sensors within these such as NLRP3 inflammasome, activated by signals that...
Abstract Alzheimer's disease (AD) is associated with the cerebral deposition of Amyloid‐β (Aβ) peptide, which leads to NLRP3 inflammasome activation and subsequent release interleukin‐1β (IL‐1β) interleukin‐18 (IL‐18). reduction has been found increase microglial clearance, protect from synapse loss, suppress both changes synaptic plasticity spatial memory dysfunction observed in murine AD models. Here, we test whether NLRP3‐directed antisense oligonucleotides (ASOs) can be harnessed as...
Abstract Cognitive functions decline during aging. This could be caused by changes in dendritic spine stability and altered dynamics. Previously, we have shown that a low dose chronic THC treatment improves learning abilities old whereas impairs young mice. The mechanism underlying this age-dependent effect is not known. Dendritic key for memory formation, therefore hypothesized affects dynamics an manner. We applied longitudinal 2-photon vivo imaging to 3- 18-month-old mice treated with 3...
Abstract Although the cannabinoid receptor 2 (CB R) is often thought to play a role mainly outside brain several publications unequivocally showed presence of CB R on hippocampal principal neurons. Activation produced long-lasting membrane potential hyperpolarization, altered input/output function CA2/3 neurons and alterations in gamma oscillations. However, other cellular, molecular behavioral consequences signaling have not been studied detail. Here we demonstrate that deletion leads...
Abstract Background Virgin coconut oil (VCO), a cold processed form of oil, is traditionally consumed in Asian countries owing to its nutritional and medicinal properties. The aim this study was investigate whether the health benefits VCO involve alterations immune responses that are regulated by intracellular signaling molecules spleens rats. Methods Young male Wistar rats were fed with three doses diet for 30 days. At end treatment period, isolated vitro effects on (Concanavalin A [Con...
Abstract Objective Virgin coconut oil (VCO) is used as a traditional medicine in Asian countries because of its therapeutic effects mediated through hypolipidemic, antimicrobial and anti‐oxidant properties. The interactions between the sympathetic noradrenergic nervous system immune cells lymphoid organs (thymus lymph nodes) modulate immunity to determine health or onset inflammatory diseases. aim present study was investigate role VCO modulating neuronal anti‐inflammatory factors thymus...
Abstract The neurovascular unit (NVU) is a complex structure comprising neurons, glia, and pericytes that interact with specialized endothelial cells to maintain cerebral homeostasis blood-brain barrier (BBB) integrity. Alterations NVU formation function can lead serious forms of cerebrovascular disease, including small vessel diseases (CSVDs), range pathological changes capillaries within the white matter contributing BBB dysfunction demyelination. Despite growing recognition pivotal roles...
Abstract Objective Sympathetic neuronal activity in the thymus and lymph nodes is differentially regulated during reproductive aging. The aim was to investigate role of estrogen on sympathetic expression mesenteric early middle‐aged ovariectomized female rats implanted with 17β‐estradiol pellets. Methods 17β‐Estradiol pellets (0.6 300) were subcutaneously Sprague–Dawley ( n = 8/group) for a period 30 days. At end treatment period, isolated analyzed tyrosine hydroxylase, nerve growth factor,...
Abstract Background While neuroinflammation is reckoned as a pathological hallmark of AD, research on suitable biomarkers still ongoing. Here, we report findings from the DZNE DELCODE, Fundacío ACE and other cohorts demonstrating distinct inflammatory biomarker profiles in CSF serum. Intriguingly, within these profiles, soluble TAM receptor markers are elevated neurodegeneration but relate to protection cognition brain structure. Method We investigated panel 20 experimental utilizing...