A5069402695- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Amyotrophic Lateral Sclerosis Research
- Functional Brain Connectivity Studies
- Assistive Technology in Communication and Mobility
- Spatial Cognition and Navigation
- Parkinson's Disease Mechanisms and Treatments
- Technology Use by Older Adults
- Language Development and Disorders
- Innovative Approaches in Technology and Social Development
- Gait Recognition and Analysis
- Neurobiology of Language and Bilingualism
- Neuroinflammation and Neurodegeneration Mechanisms
- Balance, Gait, and Falls Prevention
- Cerebrovascular and genetic disorders
- Health, Environment, Cognitive Aging
University of Rostock
2021-2023
German Center for Neurodegenerative Diseases
2021-2022
Universitätsmedizin Rostock
2020
Abstract Introduction It is uncertain whether subjective cognitive decline (SCD) in individuals who seek medical help serves the identification of initial symptomatic stage 2 Alzheimer's disease (AD) continuum. Methods Cross‐sectional and longitudinal data from multicenter, memory clinic–based DELCODE study. Results The SCD group showed slightly worse cognition as well more subtle functional behavioral symptoms than control (CO). SCD–A+ cases (39.3% all SCD) greater hippocampal atrophy,...
Abstract Background Neuroinflammation constitutes a pathological hallmark of Alzheimer’s disease (AD). Still, it remains unresolved if peripheral inflammatory markers can be utilized for research purposes similar to blood-based beta-amyloid and neurodegeneration measures. We investigated experimental inflammation in serum analyzed interrelations towards AD pathology features cohort with focus on at-risk stages AD. Methods Data 74 healthy controls (HC), 99 subjective cognitive decline (SCD),...
Several lifestyle factors promote protection against Alzheimer's disease (AD) throughout a person's lifespan. Although such protective effects have been described for occupational cognitive requirements (OCR) in midlife, it is currently unknown whether they are conveyed by brain maintenance (BM), reserve (BR), or (CR) combination of them.We systematically derived hypotheses these resilience concepts and tested them the population-based AgeCoDe cohort memory clinic-based AD high-risk DELCODE...
Abstract The number of people with dementia is increasing worldwide. At the same time, family and professional caregivers’ resources are limited. A promising approach to relieve these carers’ burden assist assistive technology. In order be useful accepted, such technologies need respect values needs their intended users. We applied value sensitive design identify patients caregivers in institutionalized care. Based on semi-structured interviews residents/patients cognitive impairment,...
People with dementia (PwD) have serious difficulties orienting themselves in a hospital environment. In this qualitative study, we asked PwD and their informal caregivers about requirements for assistive technology when navigating in-patient care settings. We aimed to provide user-centered recommendations the development of an in-hospital navigation aid following value sensitive design approach. conducted semi-structured interviews two stakeholder groups as potential future users aids: (n =...
Limbic-predominant age-related TDP-43 (Transactivation response(TAR)-DNA-binding protein 43 kDa) encephalopathy (LATE) has recently been characterized as a distinct neuropathological entity within the spectrum of dementia. Neuropathological alterations in sense LATE were already previously described comorbidity to Alzheimer's disease (AD) and it diagnosed independently from AD pathology autopsy studies since 2008. The framework would account for pathogenetic impact limbic proteinopathy...
Objective To determine whether gait and accelerometric features can predict disorientation events in young older adults. Methods Cognitively healthy younger (18–40 years, n = 25) (60–85 28) participants navigated on a treadmill through virtual representation of the city Rostock featured within Gait Real-Time Analysis Interactive Lab (GRAIL) system. We conducted Bayesian Poisson regression to association navigation performance with domain-specific cognitive functions. determined associations...