A5100756864- Inflammasome and immune disorders
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Advanced biosensing and bioanalysis techniques
- Tryptophan and brain disorders
- Adenosine and Purinergic Signaling
- Heme Oxygenase-1 and Carbon Monoxide
- Radioactivity and Radon Measurements
- Circadian rhythm and melatonin
- Obstructive Sleep Apnea Research
- Cancer-related gene regulation
- Plant Pathogens and Fungal Diseases
- Biosensors and Analytical Detection
- Circular RNAs in diseases
- Vitamin C and Antioxidants Research
- Gout, Hyperuricemia, Uric Acid
- Pediatric Hepatobiliary Diseases and Treatments
- Anesthesia and Neurotoxicity Research
- Stress Responses and Cortisol
- Nuclear Receptors and Signaling
- Advanced Glycation End Products research
- MXene and MAX Phase Materials
- Fungal Plant Pathogen Control
- Coal Properties and Utilization
- Marine Sponges and Natural Products
University of South China
2010-2025
Ministry of Education of the People's Republic of China
2011-2021
Northwest University
2021
Yantai Institute of Coastal Zone Research
2014
Chinese Academy of Sciences
2014
Capital Medical University
2011
Xinjiang Academy of Agricultural Sciences
2011
China Institute of Atomic Energy
1993
Betaine rich in beet is used as an important source of human nutrition. Here this study aims to explore whether betaine supplementation can protect against acute sever ulcerative colitis (ASUC) and the underlying mechanism METHODS AND RESULTS: ASUC model induced by dextran sulfate sodium (DSS), effects a methyl donor on are evaluated. mitigates changes, for example, elevated DAI, weight loss, spleen enlargement, colon shortening, disordered colonic mucosa. The protective barrier integrity...
Ulcerative colitis (UC) is a typical type of inflammatory bowl disease, which accompanied by an increased risk depression and anxiety-related psychological symptoms. Betaine naturally derived compound that can function as anti-inflammatory drug neuromodulator. In-depth exploration the potential role betaine in treating UC-related anxiety crucial. This study aimed to elucidate effects on clarify underlying mechanisms. A dextran sulfate sodium (DSS)-induced mice model was established 4% DSS...
Inflammatory injury of the intestine is often accompanied by symptoms such as damage to intestinal mucosa, increased permeability, and motility dysfunction. factors spread throughout body via blood circulation, can cause multi-organ failure. Pyroptosis a newly discovered way programmed cell death, which mainly characterized formation plasma membrane vesicles, swelling until rupture membrane, release contents, thereby activating drastic inflammatory response expanding cascade. widely involved...
Agrostis capillaris is a cool-season turf grass species that found worldwide in temperate countries, and good Pb phytostabilizer. In this study, the entire chloroplast genome sequence of A. was determined by Illumina sequencing. The complete circular composed 136,396 bp nucleotides with GC content about 38.5%. There were large single-copy region (LSC, 81,659bp), small (SSC, 12,593bp), pair reverse repeat regions (IRs, 42,144bp) genome. total, contained 144 genes, including 96 protein-coding...
Abstract Background Neuroinflammation is considered as a key mediator of depression. Therefore, understanding the pathophysiological mechanisms by which neuroinflammation and depression are linked can benefit novel therapies. Gonadotropin-releasing hormone (GnRH) at head neuroendocrine reproductive axis. However, non-reproductive functions GnRH expressed in various tissues, including hippocampus, still not known. Methods We combined viral tool, neuropharmacology, behavioral tests male mice...
MicroRNAs (miRNAs) are a class of small noncoding RNAs that control gene expression at the post-transcriptional level and involved in pathogenesis epilepsy. Here, we provide strong evidence support pathogenic association miRNA-32-5p (miR-32-5p) with Levels miR-32-5p were elevated plasma epilepsy patients, as well hippocampus pentylenetetrazol (PTZ)-induced seizure mice. Systemic knockout hippocampal-specific knockdown mitigated discharge neuronal hyperactivity experimental Mechanically,...
Abstract Sepsis-associated encephalopathy (SAE) manifests clinically in hyperneuroinflammation. Pyroptosis, which can induce an inflammatory cascade response, has been considered to be a causative factor of SAE. Evidence shown that the bromo- and extraterminal (BET) proteins (including BRD2, BRD3, BRD4 BRDT) inhibitor JQ1 inhibit inflammation suppress pyroptosis various diseases. Therefore, we examined effect on inflammasome-induced hippocampus mouse model sepsis induced by...