A5101845470- Parkinson's Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Neurological disorders and treatments
- Nuclear Receptors and Signaling
- Structural Engineering and Vibration Analysis
- Advanced Sensor and Control Systems
- Botulinum Toxin and Related Neurological Disorders
- Ginkgo biloba and Cashew Applications
- Advanced materials and composites
- Orthodontics and Dentofacial Orthopedics
- Restless Legs Syndrome Research
- Cholinesterase and Neurodegenerative Diseases
- Dental Radiography and Imaging
- Autophagy in Disease and Therapy
- Railway Engineering and Dynamics
- Cholesterol and Lipid Metabolism
- Craniofacial Disorders and Treatments
- Nerve injury and regeneration
- Macrophage Migration Inhibitory Factor
- Genetics, Aging, and Longevity in Model Organisms
- Civil and Geotechnical Engineering Research
- Paraoxonase enzyme and polymorphisms
- Metallurgy and Material Science
- Titanium Alloys Microstructure and Properties
- Advanced Computational Techniques and Applications
Chengdu University of Traditional Chinese Medicine
2024-2025
Stomatology Hospital
2025
Tongji University
2025
Northeastern University
2024
Horological Research Institute of Light Industry
2023
Capital Medical University
2008-2022
Beijing Geriatric Hospital
2019-2021
Shandong Institute for Product Quality Inspection
2021
Beijing Xuanwu Traditional Chinese Medicine Hospital
2020
Chongqing University of Technology
2017-2019
Abstract Background New therapies are urgently needed for Alzheimer’s disease (AD). Sodium oligomannate (GV-971) is a marine-derived oligosaccharide with novel proposed mechanism of action. The first phase 3 clinical trial GV-971 has been completed in China. Methods We conducted 3, double-blind, placebo-controlled participants mild-to-moderate AD to assess efficacy and safety. Participants were randomized placebo or (900 mg) 36 weeks. primary outcome was the drug-placebo difference change...
ABSTRACT Allium macrostemon Bge. (AM) is a widely utilized culinary spice recognized for its numerous health‐promoting properties. Aging‐related cognitive impairment (ARCI) represents significant global health concern during the aging process. However, potential of AM to attenuate ARCI has not been investigated. This work aims reveal effects and mechanisms water extraction (WEAM) in alleviating ARCI, with particular emphasis on BDNF/TrkB signaling pathway. The findings showed enhancement...
Objective To understand the viral etiology of acute childhood encephalitis in Beijing. Methods Ninety-seven Chinese children (between 7 months and 13 years age) with were retrospectively investigated. They treated Beijing Children's Hospital between June, 1991, October, 1994. Different serologic methods (immunofluorescence assay, enzyme-linked immunosorbent solid phase reverse test) used for detection IgM antibody to enteroviruses, herpesviruses, mumps, measles, rubella Japanese virus. The...
Parkinson's disease (PD) is the second most progressive neurodegenerative disorder of central nervous system in elderly, causing motor impediments and cognitive dysfunctions. Dopaminergic (DA) neuron degeneration α-synuclein (α-Syn) accumulation substantia nigra pars compacta are major contributors to this disease. At present, PD remains untreatable with a huge burden on quality life. Therefore, we attempt explore novel treatment strategies by detecting effective drugs that stop or arrest...
Enterovirus 71 (EV71) is typically transmitted by the oral-faecal route and initiates infection upon crossing intestinal mucosa. Our limited understanding of mechanisms which it crosses mucosa has hampered development effective therapeutic options. Here, using an RNA interference screen combined with chemical inhibitors or overexpression dominant negative proteins, we found that EV71 entry into Caco-2 cells, a polarized human epithelial cell line, does not involve clathrin-...
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by excessive neuronal loss in specific regions of the brain. Among areas most severely affected are basal forebrain cholinergic neurons and their projection regions, hippocampus cortex. Several lines evidence have made brain-derived neurotrophic factor (BDNF) an important candidate gene conferring risk for AD. Recently, several reports investigated association between single nucleotide polymorphism (Val66Met,...
Background Oxidative stress such as low-density lipoprotein (LDL) oxidation is thought to be an important mechanism in Alzheimer's disease (AD). Paraoxonase 1 (PON1), enzyme located on high-density lipoprotein, can prevent LDL from some extent. It also a potent cholinesterase inhibitor and arylesterase, combating organophosphate poisoning metabolization of environmental neurotoxins which might responsible for neurodegeneration with aging.We evaluated the association Gln192Arg polymorphism...
Objective: Recent studies suggest that not only is constipation a clinical marker of premotor phase in Parkinson’s Disease (PD), but also correlated with the duration and severity. Some reports indicated inflammatory from gut dysbiosis might be involved pathogenesis PD, correlation between them remains poorly understood. This study aims to investigate how presence affects dopamine level nigrostriatal system whether gastrointestinal (GI) inflammation brain-gut axis. Methods: Clinical...
In this paper, we combine the mature technology of Web with embedded and fully utilize advantages both. Applied in field equipment condition monitoring, remote monitoring system is designed based on Web. Firstly, function structure are designed. Based ARM9 technology, hardware part by using Samsung's S3C2410, ADC0809 DM9000 chips. Secondly, commonly design server integrating CGI (common gateway interface), ActiveX Java Applet technology. Finally, problem communication security considered....
Background: Freezing of gait (FOG) could be partly alleviated by dopaminergic drugs but the mechanism still needs to elucidated. The purpose this study is explore mechanisms FOG vesicular monoamine transporter VMAT2 distribution with 18F-AV133 tracer and 18-fludeoxyglucose positron emission tomography-computed tomography (18F-FDG PET-CT). Methods: Clinical material PET-CT data were collected from 20 patients 147 without November 1, 2017 October 31, 2018. Brain scans all participants acquired...