A5100435511- Neurological Disease Mechanisms and Treatments
- Neurological Disorders and Treatments
- Biological and pharmacological studies of plants
- Tryptophan and brain disorders
- Inflammasome and immune disorders
- Parkinson's Disease Mechanisms and Treatments
- Histone Deacetylase Inhibitors Research
- Autophagy in Disease and Therapy
- Sunflower and Safflower Cultivation
- Calcium signaling and nucleotide metabolism
- Eicosanoids and Hypertension Pharmacology
- Traditional Chinese Medicine Analysis
- Phytochemical Studies and Bioactivities
- Biochemical effects in animals
- Angiogenesis and VEGF in Cancer
- Ginkgo biloba and Cashew Applications
- Natural product bioactivities and synthesis
- Neuroinflammation and Neurodegeneration Mechanisms
- Organoselenium and organotellurium chemistry
- Rheumatoid Arthritis Research and Therapies
- Urticaria and Related Conditions
- Nitric Oxide and Endothelin Effects
- Genomics, phytochemicals, and oxidative stress
- Dermatology and Skin Diseases
- Neurotransmitter Receptor Influence on Behavior
Chengdu University of Traditional Chinese Medicine
2020-2024
Hunan University of Traditional Chinese Medicine
2023
China Pharmaceutical University
2021-2022
Sun Yat-sen University
2022
Southwestern Institute of Physics
2022
Peking University Shenzhen Hospital
2022
Nathan Kline Institute for Psychiatric Research
2011
Chengdu University
2010
Increased glycolytic in fibroblast-like synoviocytes (FLS) of rheumatoid arthritis (RA) not only contributes to early-stage disease pathogenesis but leads sustained proliferation FLS. Given the importance PKM2 glycolysis and apoptosis, is considered a potential therapeutic drug discovery target RA. Total saponins anemarrhena (TSA), class steroid saponins, originated from Anemarrhena asphodeloides Bge. In this study, we verified that 200 mg/kg TSA could significantly alleviate inflammation...
Vascular endothelial growth factor (VEGF) is critical to angiogenesis and vascular permeability. It also important in the endocrine system, which VEGF mediates effects of estrogens target tissues such as uterus, a response attributed an estrogen element on gene. Here we asked whether 17β-estradiol increases levels brain. We focused hippocampus, both have actions, used immunocytochemistry evaluate protein. immunoreactivity was compared adult female rats sampled during estrous cycle when serum...
Multi-infarct dementia (MID), a prominent subtype of vascular (VD), is responsible for at least 15 to 20 percent in the elderly. Mitochondrial dysfunctions and glutamate neurotoxicity due chronic hypoperfusion oxidative stress were regarded as major risk factors pathogenesis.
Zonula occludens-1 (ZO-1) is a tight junction protein in the cerebrovascular endothelium, responsible for blood-brain barrier function. Hydroxysafflor yellow A (HSYA) major ingredient of safflower (Carthamus tinctorius L.) with antioxidative activity. This study investigated whether HSYA protected ZO-1 by targeting ROS-generating NADPH oxidases (NOXs). administration reduced cerebral vascular leakage protection mice after photothrombotic stroke, largely due to suppression ROS-associated...
Zanthoxylum bungeanum Maxim (Rutaceae), a medicinal herb and foodstuff, has previously been demonstrated as useful for the potential prevention of age-related cognitive dysfunction. However, mechanisms material basis remain elusively understood. The impairment by four fractions Z. was evaluated in D-galactose-induced aging mice, including petroleum ether (PE), methylene chloride (DCM), ethyl acetate (EA), n-butanol (N-BAI). results showed that mice treated with EA N-BAI had significantly...
This study investigated the mechanism of Danggui Shaoyao Powder(DSP) against mitophagy in rat model Alzheimer's disease(AD) induced by streptozotocin(STZ) based on PTEN putative kinase 1(PINK1)-Parkin signaling pathway. The AD was established injecting STZ into lateral ventricle, and rats were divided normal group, DSP low-dose group(12 g·kg~(-1)·d~(-1)), medium-dose group(24 high-dose group(36 g·kg~(-1)·d~(-1)). Morris water maze test used to detect learning memory function rats,...
Ligustilide is a phenolic compound isolated from Asian plants of Umbelliferae family. This study was aimed at exploring the neuroprotective effects perspective endoplasmic reticulum stress (ERS) and autophagy. The Alzheimer's disease (AD) cell models were constructed by SH‐SY5Y line, which exposed to 20 μM Aβ 25‐35 . CCK‐8 used evaluate viability on AD model. Hoechst staining LysoTracker Red test apoptosis Lysosome function, respectively. ERS in living cells detected Thioflavin T. expression...
Endothelial cell activation plays a critical role in leukocyte recruitment during inflammation and infection. We previously found that cholinergic stimulation (via vagus nerve stimulation) attenuates vascular endothelial impairment reduces the inflammatory profile ovariectomized rats. However, specific molecular mechanism is unclear. This study was designed to explore effects mechanisms of agonists (acetylcholine [ACh]) on lipopolysaccharide (LPS)-induced vitro. Human umbilical vein cells...
Abstract Background : Zonula occludens-1 (ZO-1) protein ensures cerebrovascular integrity against brain ischemic injury. Hydroxysafflor yellow A (HSYA) is a major ingredient of safflower ( Carthamus tinctorius L.) with anti-oxidative activity. Because conventional ROS scavengers display poor reactivity endogenous ROS, this study investigated whether HSYA protected ZO-1 by targeting the enzymes responsible for generation. Methords Photothrombotic stroke model was prepared in mice to evaluate...
Abstract The vesicular monoamine transporter (VMAT2) plays a crucial role in maintaining dopamine (DA) homeostasis through packaged DA into vesicles, which has been suggested to being an excellent marker for presynaptic dopaminergic nerve terminals the nigrostriatal of Parkinson's disease. Gastrodin (GTD), major bioactive compound Gastrodia elata , shown neuroprotective animal models many neurological disorders. However, it is unclear whether GTD confers neuroprotection via activating VMAT2...
Objective : To investigate the influence of stellate ganglion block on prognosis patients with hypertensive intracerebral hemorrhage according to inclusion criteria and whether complications such as rebleeding pulmonary infection are related occurrence recurrent infection. The use blockade in clinical application cerebrovascular disease possible risks. Methods A total 138 who were treated different treatments neurosurgery from March 2013 December 2015 included study. Among them, 67 treatment...
Abstract Background: The NLRP3-mediated pyroptosis is a key player in the development of age-associated neurodegenerative disease. Zanthoxylum bungeanum Maxim (Rutaceae), homologous medicine and foodstuff, has previously been demonstrated potential prevention cognitive dysfunction aging mice. However, it still unknown which fraction material basis responsible for their therapeutic effects whether Z. could confer anti-cognitive deficits activity via restraining pyroptosis. Thus, current...