A5060361199- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Suicide and Self-Harm Studies
- Functional Brain Connectivity Studies
- Fatty Acid Research and Health
- Bipolar Disorder and Treatment
- Treatment of Major Depression
- Diet and metabolism studies
- Mental Health Research Topics
- Child and Adolescent Psychosocial and Emotional Development
- Alcoholism and Thiamine Deficiency
- Neurotransmitter Receptor Influence on Behavior
- Eicosanoids and Hypertension Pharmacology
- Resilience and Mental Health
- Advanced Neuroimaging Techniques and Applications
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neuroscience and Neuropharmacology Research
- Mental Health Treatment and Access
- Electroconvulsive Therapy Studies
- Maternal Mental Health During Pregnancy and Postpartum
- Advanced MRI Techniques and Applications
- Gut microbiota and health
- Health, psychology, and well-being
- Medical Imaging Techniques and Applications
- Child Abuse and Trauma
Columbia University Irving Medical Center
2017-2024
New York Psychoanalytic Society and Institute
2015-2024
Columbia University
2015-2024
New York State Psychiatric Institute
2015-2024
New York College of Health Professions
2024
Centro de Investigación Biomédica en Red de Salud Mental
2015
Universidad Autónoma de Madrid
2015
Instituto de Salud Carlos III
2015
University of York
2013
VA Capitol Health Care Network
2012
Background: Recently discovered relationships between the gastrointestinal microbiome and brain have implications for psychiatric disorders, including major depressive disorder (MDD). Bacterial transplantation from MDD patients to rodents produces depression-like behaviors. In humans, case-control studies examined gut in healthy affected individuals. We systematically reviewed existing comparing microbial composition volunteers. Methods: A PubMed literature search combined terms...
Pharmacotherapy to rapidly relieve suicidal ideation in depression may reduce suicide risk. Rapid reduction thoughts after ketamine treatment has mostly been studied patients with low levels of ideation. The authors tested the acute effect adjunctive subanesthetic intravenous on clinically significant major depressive disorder.In a randomized clinical trial, adults (N=80) current disorder and score ≥4 Scale for Suicidal Ideation (SSI), whom 54% (N=43) were taking antidepressant medication,...
This study aims to characterize the gut microbiota in depressed patients with bipolar disorder (BD) compared healthy controls (HCs), examine effects of quetiapine treatment on microbiota, and explore potential as a biomarker for BD diagnosis outcome. Analysis 16S-ribosomal RNA gene sequences reveals that microbial composition diversity are significantly different between HCs. Phylum
Objective: Low levels of docosahexaenoic acid, a polyunsaturated fatty and elevated ratios omega-6/omega-3 acids are associated with major depression and, possibly, suicidal behavior. Predicting risk future behaviors by essential acid status merits examination. Method: Plasma in phospholipids were measured 33 medication-free depressed subjects monitored for suicide attempt over 2-year period. Survival analysis examined the association plasma pathological outcome. Results: Seven attempted on...
Bipolar disorder is associated with high risk for suicidal acts. Observational studies suggest a protective effect of lithium against behavior. However, testing this in randomized clinical trials logistically and ethically challenging. The authors tested the hypothesis that offers bipolar patients history suicide attempt greater protection behavior compared to valproate.Patients past attempts (N=98) were randomly assigned treatment or valproate, plus adjunctive medications as indicated,...
Objectives To evaluate feasibility and effects of a sub-anesthetic infusion dose ketamine versus midazolam on suicidal ideation in bipolar depression. Neurocognitive, blood saliva biomarkers were explored. Methods Sixteen participants with depression Scale for Suicidal Ideation (SSI) score ≥4 randomized to (0.5 mg/kg) or (0.02 mg/kg). Current pharmacotherapy was maintained excluding benzodiazepines within 24 hours. The primary clinical outcome SSI day 1 post-infusion. Results supported...
<h3>Importance</h3> Biomarkers that predict suicidal behavior, especially highly lethal are urgently needed. In cross-sectional studies, individuals with depression who attempt suicide have lower midbrain serotonin transporter binding potential compared those do not suicide, and higher serotonin<sub>1A</sub>binding in the raphe nuclei (RN) is associated greater lethality of past attempts intent ideation. <h3>Objectives</h3> To determine whether predicts future RN ideation attempts....
This study compared regional cerebral metabolic rates of glucose (rCMRglu) determined by [(18)F]-fluoro-2-deoxyglucose positron emission tomography (FDG-PET) in suicide attempters and non-attempters. Medication-free patients with major depression (n = 29) had FDG-PET after single-blind administration placebo (day 1) fenfluramine 2). Suicide attempt history was obtained before scanning at assessments over 2 subsequent years. Statistical parametric mapping evaluated associations between status...
Polyunsaturated fatty acid (PUFA) status has been associated with neuropsychiatric disorders, including depression and risk of suicide. Long-chain PUFAs (LC-PUFAs) are obtained in the diet or produced by sequential desaturation elongation shorter-chain precursor acids linoleic (LA, 18:2n-6) α-linolenic (ALA, 18:3n-3). We compared DNA methylation patterns genes involved LC-PUFA biosynthesis major depressive disorder (MDD) (n = 22) without 39) history suicide attempt, age- sex-matched healthy...
Objectives Bipolar disorder ( BD ) is a psychiatric with high morbidity and mortality that cannot be distinguished from major depressive MDD until the first manic episode. A biomarker able to differentiate could help clinicians avoid risks of treating antidepressants without mood stabilizers. Methods Cortical thickness differences were assessed using magnetic resonance imaging in depressed patients (n = 18), 56), healthy volunteers HV s) 54). general linear model identified clusters cortical...
Article AbstractBackground: Although lower levels of omega-3 polyunsaturated fatty acids (PUFAs) are found in major depressive disorder, less is known about PUFA status and anxiety disorders. Method: Medication-free participants with DSM-IV-defined disorder (MDD), (n = 18) without 41) comorbid DSM-IV disorders, healthy volunteers 62) were recruited from October 2006 to May 2010 for mood studies at the New York State Psychiatric Institute. Participants 18-73 years age (mean age, 35.8 ± 12.6...