A5042497043- Functional Brain Connectivity Studies
- Dementia and Cognitive Impairment Research
- Maternal Mental Health During Pregnancy and Postpartum
- Advanced Neuroimaging Techniques and Applications
- Alzheimer's disease research and treatments
- Birth, Development, and Health
- Olfactory and Sensory Function Studies
- Child and Adolescent Psychosocial and Emotional Development
- Parkinson's Disease Mechanisms and Treatments
- Neurological Disease Mechanisms and Treatments
- Schizophrenia research and treatment
- Child Abuse and Trauma
- Neural dynamics and brain function
- Amyotrophic Lateral Sclerosis Research
- Mental Health Research Topics
- Eating Disorders and Behaviors
- Obsessive-Compulsive Spectrum Disorders
- Advanced MRI Techniques and Applications
- Blind Source Separation Techniques
- Neural and Behavioral Psychology Studies
- Epigenetics and DNA Methylation
- Neuroinflammation and Neurodegeneration Mechanisms
- EEG and Brain-Computer Interfaces
- Health, Environment, Cognitive Aging
- Neonatal and fetal brain pathology
Columbia University
2016-2025
Korea Research Institute of Bioscience and Biotechnology
2025
Gyeongsang National University Hospital
2025
Gyeongsang National University
2024-2025
Columbia University Irving Medical Center
2015-2024
New York State Psychiatric Institute
2015-2024
New York Psychoanalytic Society and Institute
2015-2024
New York State Office of Mental Health
2018-2024
Research Foundation For Mental Hygiene
2018-2024
Samsung Medical Center
2024
White matter hyperintensities (WMHs) are areas of increased signal on T2-weighted magnetic resonance imaging (MRI) scans that most commonly reflect small vessel cerebrovascular disease. Increased WMH volume is associated with risk and progression Alzheimer's disease (AD). These observations typically interpreted as evidence vascular abnormalities play an additive, independent role contributing to symptom presentation, but not core features AD. We examined the severity distribution in...
<h3>Objective:</h3> To determine the predictive utility of baseline odor identification deficits for future cognitive decline and diagnosis Alzheimer disease (AD) dementia. <h3>Methods:</h3> In a multiethnic community cohort in North Manhattan, NY, 1,037 participants without dementia were evaluated with 40-item University Pennsylvania Smell Identification Test (UPSIT). 757 participants, follow-up occurred at 2 years 4 years. <h3>Results:</h3> logistic regression analyses, lower UPSIT scores...
Objective: Increased risk of psychopathology is observed in children exposed to maternal prenatal distress, and elevated cortisol epigenetic regulation placental glucocorticoid-pathway genes are potential mechanisms. The authors examined distress salivary relation fetal movement heart rate (“coupling”) DNA methylation three glucocorticoid pathway genes—HSD11B2, NR3C1, FKBP5—in term placentas. Method: Mood questionnaires were collected from 61 women between 24–27 gestational weeks, assessment...
Significance Despite decades of prenatal programming research showing that “the womb may be more important than the home” with respect to offspring health outcomes, no studies which we are aware have considered multiple indicators maternal stress identify types most influence developing offspring. This study’s key contributions include use a data-driven procedure specify stress—psychological and subclinical physical indicators—that predict outcomes including sex at birth, risk preterm fetal...
ObjectiveTo determine efficacy of aerobic exercise for cognitive function in younger healthy adults. MethodsIn a randomized, parallel-group, observer-masked, community-based clinical trial, 132 cognitively normal individuals aged 20-67 with below median capacity were randomly assigned to one two 6-month, 4-times-weekly conditions: and stretching/ toning.Efficacy measures included capacity; several domains (executive function, episodic memory, processing speed, language, attention), everyday...
This study explored the relationship of specific symptoms borderline personality disorder to dimensions severity sexual abuse experiences in childhood.A group 41 patients with who retrospectively reported a childhood history on Familial Experiences Interview were studied. Six items from Diagnostic for Borderline Patients (DIB) chosen basis their univariate (chi-square) association scale that was developed by authors and research team. These six DIB each modeled logistic regression. Predictor...
To examine the association between odor identification deficits and future mortality in a multiethnic community cohort of older adults.Participants were evaluated with 40-item University Pennsylvania Smell Identification Test (UPSIT). Follow-up occurred at 2-year intervals information on death obtained from informant interviews National Death Index.During follow-up (mean = 4.1 years, standard deviation 2.6), 349 1,169 (29.9%) participants died. Participants who died more likely to be (p <...
Introduction White matter hyperintensity (WMH) volume on MRI is increased among presymptomatic individuals with autosomal dominant mutations for Alzheimer's disease (AD). One potential explanation that WMH, conventionally considered a marker of cerebrovascular disease, are reflection cerebral amyloid angiopathy (CAA) and WMH in this population manifestation vascular form primary AD pathology. We examined whether the presence microbleeds, CAA, mediates relationship between estimated symptom...
<h3>Importance</h3> Understanding associations of Alzheimer disease (AD) and related dementias (ADRD) pathologies with common neuropsychiatric symptoms (NPS) may have implications for diagnosis management. <h3>Objective</h3> To evaluate ADRD neuropathological diagnoses NPS without consideration clinical diagnosis. <h3>Design, Setting, Participants</h3> This retrospective cohort study evaluated 1808 brains from 39 sites in the US National Coordinating Center v. 10 collection participants...
Abstract INTRODUCTION Evidence suggests microglial activation precedes regional tau and neurodegeneration in Alzheimer's disease (AD). We characterized microglia with translocator protein (TSPO) positron emission tomography (PET) within an AD progression model where global amyloid beta (Aβ) local neurodegeneration, resulting cognitive impairment. METHODS Florbetaben, PBR28, MK‐6240 PET, T1 magnetic resonance imaging, measures were performed 19 cognitively unimpaired older adults 22 patients...
Background: Memory decline is common in multiple sclerosis (MS), although pathophysiological mechanisms are not fully understood. Objective: The objective was to investigate the relationship of changes structural and functional neuroimaging markers memory over 3-year follow-up. Methods: Participants with MS underwent cognitive evaluation structural, diffusion, 3T magnetic resonance imaging (MRI) scans at baseline Changes metrics from follow-up were compared between stable groups. Our...
Deficits in attention have been implicated Obsessive-Compulsive Disorder (OCD), yet their neurobiological bases are poorly understood. In unmedicated adults with OCD (n = 30) and healthy controls 32), they used resting state functional connectivity MRI (rs-fcMRI) to examine between two neural networks associated attentional processes: the default mode network (DMN) salience (SN). They then path analyses putative relationships across three variables of interest: DMN-SN connectivity,...
High frequency (HF) heart rate variability (HRV) has long been accepted as an index of cardiac vagal control. Recent studies report relationships between HF-HRV and indices positive negative affect, personality traits well-being but these generally are based on small selective samples.These were examined using data from 967 participants in the second Midlife U.S. (MIDUS II) study. Participants completed survey questionnaires affect. was measured at rest. A hierarchical series regression...
ABSTRACT Prenatal maternal distress is associated with an at‐risk developmental profile, yet there little fetal evidence of this putative in utero process. Moreover, the biological transmission for these effects remains uncertain. In a study n = 125 pregnant adolescents (ages 14–19), ambulatory assessments daily negative mood (anger, frustration, irritation, stress), physical activity, blood pressure, heart rate (every 30 min over 24 hr), and salivary cortisol (six samples) were collected at...
Limited data exist on child abuse-related immune variation during pregnancy, despite implications for maternal and infant health extensive showing that abuse history depression are related to increased inflammation in other populations. This study examined associations among abuse, depression, circulating levels of inflammatory markers, perinatal pregnant adolescents, a group at high risk childhood poor birth outcomes.Pregnant teenagers (n = 133; 14-19 years; 89.5% Latina) reported had two...
Abstract There is increasing focus on use of resting-state functional connectivity (RSFC) analyses to subtype depression and predict treatment response. To date, identification RSFC patterns associated with response electroconvulsive therapy (ECT) remain limited, focused interactions between dorsal prefrontal regions the limbic or default-mode networks. Deficits in visual processing are reported depression, however, within network have not been explored recent models depression. Here, we...