A5031819552- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Advanced Neuroimaging Techniques and Applications
- Heavy Metal Exposure and Toxicity
- Trace Elements in Health
- Genetic Neurodegenerative Diseases
- RNA regulation and disease
- Nuclear Receptors and Signaling
- Traumatic Brain Injury Research
- Cerebrospinal fluid and hydrocephalus
- Balance, Gait, and Falls Prevention
- Botulinum Toxin and Related Neurological Disorders
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- Autism Spectrum Disorder Research
- Medical Image Segmentation Techniques
- Cerebral Palsy and Movement Disorders
- Transcranial Magnetic Stimulation Studies
- Olfactory and Sensory Function Studies
- Viral Infections and Immunology Research
- Electrical and Bioimpedance Tomography
- Anatomy and Medical Technology
- Neurobiology of Language and Bilingualism
- RNA Research and Splicing
- Neurological Disorders and Treatments
Pennsylvania State University
2016-2025
Penn State Milton S. Hershey Medical Center
2015-2024
Dong-A University
2023
Hershey (United States)
2016-2019
Capital Medical University
2004-2018
Siemens (China)
2008
Institute of Microbiology
2001
Recent magnetic resonance imaging studies suggest an increased transverse relaxation rate and reduced diffusion tensor fractional anisotropy values in the substantia nigra Parkinson's disease. The changes may reflect different aspects of disease-related pathological processes (ie, tissue iron deposition microstructure disorganization). This study investigated combined High-resolution (T2-weighted, T2*, imaging) were obtained from 16 disease patients controls. Bilateral nigras delineated...
Parkinson's disease (PD) is marked pathologically by dopamine neuron loss and iron overload in the substantia nigra pars compacta. Midbrain content reported to be increased PD based on magnetic resonance imaging (MRI) R2* changes. Because quantitative susceptibility mapping a novel MRI approach measure content, we compared it with for assessing midbrain changes PD.Quantitative maps were obtained from 47 patients healthy controls. values analyzed using both voxel-based region-of-interest...
Automated segmenting and labeling of individual brain anatomical regions, in MRI are challenging, due to the issue structural variability. Although atlas-based segmentation has shown its potential for both tissue structure segmentation, inherent natural variability as well disease-related changes MR appearance, a single atlas image is often inappropriate represent full population datasets processed given neuroimaging study. As an alternative case use multiple atlases alongside label fusion...
There is a critical need to develop valid, non-invasive biomarkers for Parkinsonian syndromes. The current 17-site, international study assesses whether diffusion MRI (dMRI) can distinguish between
Abstract Background The objective of this study was to determine whether neurotoxic kynurenine metabolites, induced by inflammation, in plasma and cerebrospinal fluid (CSF) are associated with symptom severity nigral pathology Parkinson's disease (PD). Methods Clinical MRI data were obtained from 97 PD 89 controls. We used ultra‐performance liquid chromatography quantify metabolites high‐sensitivity multiplex assays inflammation CSF. evaluated group‐wise differences as well associations...
The pattern of dopamine cell loss in Parkinson's disease (PD) is known to be prominent the ventrolateral and caudal substantia nigra (SN), but less severe dorsal rostral region. Both diffusion tensor imaging (DTI) R2* relaxometry SN have been reported as potential markers for PD, their relative ability mark progression differences pathophysiological bases remains unclear. High-resolution T2-weighted, R2*, DTI were obtained from 28 controls 40 PD subjects [15 early stage [disease duration ≤1...
Abstract Background: Susceptibility MRI may capture Parkinson's disease‐related pathology. This study delineated longitudinal changes in different substantia nigra regions. Methods: Seventy‐two PD patients and 62 controls were studied at both baseline after 18 months with MRI. R2* quantitative susceptibility mapping values from the pars compacta reticulata calculated. Mixed‐effects models compared or subgroups having disease durations: early (<1 year), middle (<5 years, middle‐stage...
Abstract Background Imaging markers that are sensitive to parkinsonism across multiple sites critically needed for clinical trials. The objective of this study was evaluate changes in the substantia nigra using single‐ and bi‐tensor models diffusion magnetic resonance imaging PD, MSA, PSP. Methods cohort (n = 425) included 107 healthy controls 184 63 71 PSP patients from 3 movement disorder centers. Bi‐tensor free water, free‐water‐corrected fractional anisotropy, mean diffusivity,...
ABSTRACT Background Circulating cholesterol levels have been linked to PD, but not directly brain physiology. Objective To assess whether metabolism is related PD. Methods Sixty PD patients and 64 controls were recruited from an academic movement disorder clinic (2009–2012). Thirty‐five 33 returned approximately 36 months later. Fasting plasma (S) 24‐OH‐cholesterol (brain‐derived metabolite) 27‐OH‐cholesterol (peripheral quantified. Odds ratios for derived logistic regression models,...
ABSTRACT Background Deposition and spreading of misfolded proteins (α‐synuclein tau) have been linked to Parkinson's disease cognitive dysfunction. The glymphatic system may play an important role in the clearance these toxic via cerebrospinal fluid (CSF) flow through perivascular interstitial spaces. Recent studies discovered that sleep‐dependent global brain activity is coupled CSF flow, which reflect function. Objective objective this current study was determine if decoupling activity–CSF...
Abstract Background Higher nigral iron has been reported in Parkinson's disease (PD). Objective The aim is to understand the dynamics of accumulation PD and its association with drug treatment. Methods Susceptibility magnetic resonance imaging data were obtained from 79 controls 18 drug‐naive (PD DN ) 87 drug‐treated DT patients. Regional brain basal ganglia cerebellar structures was estimated using quantitative susceptibility mapping. Nigral compared between subgroups defined by duration...
Background: Reduced arm swing amplitude, symmetry, and coordination during gait have been reported in Parkinson's disease (PD), but the relationship between dopaminergic depletion these upper limb changes remains unclear. Objective: We aimed
ABSTRACT Background Olfactory dysfunction is often associated with Parkinson's disease (PD) and can precede characteristic motor symptoms by several years. Olfactory‐related cortical atrophy has been reported in PD, although the extent association between olfactory have controversial. The present study examined whether gray matter (GM) volume brain regions subserving primary secondary processing. Methods High‐resolution T1‐weighted MRIs were acquired from 40 PD without dementia matched...
<h3>Objective:</h3> Nigrostriatal terminal losses are known to progress most rapidly in early-stage Parkinson disease (PD) and then plateau, whereas cortical pathology continues may provide a better marker of PD progression later stages. We investigated gyrification indices patients with different durations PD, since folding capture complex processes involving transverse forces neuronal sheets or underlying axonal connectivity. <h3>Methods:</h3> Longitudinal cohort structural MRI were...
Importance Magnetic resonance imaging (MRI) paired with appropriate disease-specific machine learning holds promise for the clinical differentiation of Parkinson disease (PD), multiple system atrophy (MSA) parkinsonian variant, and progressive supranuclear palsy (PSP). A prospective study is needed to test whether approach meets primary end points be considered in a diagnostic workup. Objective To assess discriminative performance Automated Imaging Differentiation Parkinsonism (AIDP) using...
Welding-generated metallic fumes contain a substantial amount of manganese (Mn), making welders susceptible to Mn toxicity. Although overt toxicity manifests as type parkinsonism, the consequences chronic, low-level exposure are unknown. To explore region-specific accumulation and its potential functional at subclinical levels exposure, we studied seven without obvious neurological deficits age- gender-matched controls. for was estimated by an occupational questionnaire. High-resolution...
Although the essential element manganese (Mn) is neurotoxic at high doses, effects of lower exposure are unclear.MRI T1-weighted (TIW) imaging has been used to estimate brain Mn via pallidal index (PI), defined as T1W intensity ratio in globus pallidus (GP) versus frontal white matter (FWM).PI may not, however, be sensitive GP because also accumulate FWM.This study explored: (1) whether T1 relaxation rate (R1) could quantify accumulation more sensitively; and (2) dose-response relationship...
ABSTRACT Background : Parkinsonisms are neurodegenerative disorders characterized pathologically by α‐synuclein‐positive (e.g., PD, diffuse Lewy body disease, and MSA) and/or tau‐positive PSP, cortical basal degeneration) pathology. Using R2* quantitative susceptibility mapping, changes have been reported in the midbrain of living parkinsonian patients, although exact underlying pathology these alterations is unknown. Objective The current study investigated pathological correlates MRI...
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized clinically by motor dysfunction (bradykinesia, rigidity, tremor, and postural instability), pathologically the loss of dopaminergic neurons in substantia nigra basal ganglia. Growing literature supports that cognitive deficits may also be present PD, even non-demented patients. Gray matter (GM) atrophy has been reported PD related to decline. This study investigated cortical thickness subjects elucidated its...