A5032673610- Synthesis and properties of polymers
- Epoxy Resin Curing Processes
- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Membrane Separation and Gas Transport
- Silicone and Siloxane Chemistry
- Fibroblast Growth Factor Research
- Advanced Neuroimaging Techniques and Applications
- Oral Health Pathology and Treatment
- Graphene research and applications
- Metastasis and carcinoma case studies
- Head and Neck Cancer Studies
- Oral and Maxillofacial Pathology
- Traumatic Ocular and Foreign Body Injuries
- Catalytic C–H Functionalization Methods
- Fluorine in Organic Chemistry
- Sinusitis and nasal conditions
- Lignin and Wood Chemistry
- Cell death mechanisms and regulation
- Facial Trauma and Fracture Management
- Biofuel production and bioconversion
- T-cell and Retrovirus Studies
- Hedgehog Signaling Pathway Studies
- Cutaneous Melanoma Detection and Management
- Advanced Cellulose Research Studies
Haldia Institute of Technology
2018-2024
Memorial Sloan Kettering Cancer Center
2017
The University of Texas MD Anderson Cancer Center
2017
Heidelberg University
2017
University Hospital Heidelberg
2017
Cornell University
2017
Penn State Milton S. Hershey Medical Center
2011-2016
North Carolina State University
2015
Novartis (United States)
2014
Tris Pharma (United States)
2014
Purpose No standard treatment exists for patients with cholangiocarcinoma whom first-line gemcitabine-based therapy fails. Fibroblast growth factor receptor 2 ( FGFR2) fusions/translocations are present in 13% to 17% of intrahepatic cholangiocarcinomas. BGJ398, an orally bioavailable, selective pan-FGFR kinase inhibitor, has shown preliminary clinical activity against tumors FGFR alterations. Methods A multicenter, open-label, phase II study ClinicalTrials.gov identifier: NCT02150967)...
Recent magnetic resonance imaging studies suggest an increased transverse relaxation rate and reduced diffusion tensor fractional anisotropy values in the substantia nigra Parkinson's disease. The changes may reflect different aspects of disease-related pathological processes (ie, tissue iron deposition microstructure disorganization). This study investigated combined High-resolution (T2-weighted, T2*, imaging) were obtained from 16 disease patients controls. Bilateral nigras delineated...
Polyimides are proved to be an important class of polymers due their outstanding set physical and chemical properties. However, this suffers from poor processability, which limits scope application. This review article deals with approaches that have been undertaken by different researchers improve the processability polymers. Mostly, these synthetic using new diamine dianhydride monomers reduce interchain interaction final poyimide flexibilizing polymer chain or increasing fraction free...
Summary Dickkopf‐1 ( DKK 1), expressed by myeloma cells, suppresses osteoblast function and plays a key role in bone disease multiple myeloma. BHQ 880, human neutralizing IgG1 anti‐ 1 monoclonal antibody, is being investigated for its impact on myeloma‐related as an agent with potential anti‐myeloma activity. The primary objectives of this Phase IB study were to determine the maximum tolerated dose MTD ) 880 characterize dose‐limiting toxicity DLT escalating doses combination therapy...
The pattern of dopamine cell loss in Parkinson's disease (PD) is known to be prominent the ventrolateral and caudal substantia nigra (SN), but less severe dorsal rostral region. Both diffusion tensor imaging (DTI) R2* relaxometry SN have been reported as potential markers for PD, their relative ability mark progression differences pathophysiological bases remains unclear. High-resolution T2-weighted, R2*, DTI were obtained from 28 controls 40 PD subjects [15 early stage [disease duration ≤1...
Abstract Background: Fibroblast growth factor receptors (FGFRs) play a role in cell proliferation and survival. Genetic alterations of FGFRs can lead to deregulated activation various cancers, including squamous carcinoma (SCC) the lung urothelial bladder cancer. Here, we report on phase I study BGJ398 potent, selective pan-FGFR inhibitor. Methods: Eligible patients (pts; ≥ 18 years age) had tumors with any FGFR genetic alteration identified by central or local prescreening. Pts received...
335 Background: CCA is a hepatobiliary malignancy with poor prognosis and few treatment options following cytotoxic therapy in the first-line metastatic setting. The fibroblast growth factor receptor (FGFR) axis may promote tumorigenesis. FGFR2 fusions (in up to 17% of intrahepatic CCAs) predict FGFR inhibitor sensitivity. A prior phase 1 trial selective pan-FGFR BGJ398 showed antitumor activity pt harboring an fusion. Methods: This ongoing 2, open-label study evaluating oral 125 mg once...
TPS146 Background: KRAS is the most frequently mutated oncogene in cancer and a key mediator of RAS/MAPK signaling cascade that promotes cellular growth proliferation. G12C tumor mutations occur approximately 14% patients with lung adenocarcinoma 3-4% colorectal adenocarinoma. SHP2 phosphatase acts as from receptor tyrosine kinases (RTKs) to downstream pathways. Adagrasib (MRTX849) specific small-molecule investigational inhibitor covalently binds locks mutant its GDP-bound inactive form....
Welding-generated metallic fumes contain a substantial amount of manganese (Mn), making welders susceptible to Mn toxicity. Although overt toxicity manifests as type parkinsonism, the consequences chronic, low-level exposure are unknown. To explore region-specific accumulation and its potential functional at subclinical levels exposure, we studied seven without obvious neurological deficits age- gender-matched controls. for was estimated by an occupational questionnaire. High-resolution...
8034 Background: Identifying molecular drivers in lung squamous cell carcinoma (SCC) is a major medical need since no targeted therapy available yet for this subtype. Fibroblast growth factor receptors (FGFRs) are physiologically involved proliferation and survival. Genetic alteration of FGFR genes leads to deregulated activation various cancers, FGFR1 amplification has been detected SCC. Here, we report on patients (pts) with FGFR1-amplified SCC treated phase 1 study BGJ398, potent,...
Abstract Significant differences have been observed in the steady-state permeation of gases through symmetric and asymmetric (Loeb-type) cellulose acetate membranes. The studies were made with O2, N2, Ar, Kr, Xe, CO2 temperature range from -5 to 85°C at subatmospheric pressures. behavior may reflect structural between membranes dense surface layer ("skin") overall mechanism gas appears be one "solution-diffusion," similar that many other nonporous polymeric In case membranes, this is...