A5103038635- HIV Research and Treatment
- Neonatal Respiratory Health Research
- HIV/AIDS drug development and treatment
- Lung Cancer Research Studies
- Lung Cancer Treatments and Mutations
- HIV/AIDS Research and Interventions
- Congenital Diaphragmatic Hernia Studies
- Cancer Immunotherapy and Biomarkers
- Metastasis and carcinoma case studies
- Cancer Treatment and Pharmacology
- Medical and Biological Sciences
- Agriculture and Rural Development Research
- Hepatitis Viruses Studies and Epidemiology
- Infant Development and Preterm Care
- Fibroblast Growth Factor Research
- Metabolism and Genetic Disorders
- Hepatitis B Virus Studies
- Receptor Mechanisms and Signaling
- Breast Lesions and Carcinomas
- HER2/EGFR in Cancer Research
- Brain Metastases and Treatment
- Pregnancy and preeclampsia studies
- Neonatal Health and Biochemistry
- Vasculitis and related conditions
- Hepatitis C virus research
Inserm
2025
Centre Hospitalier Universitaire Amiens-Picardie
2024
Centre hospitalier régional de la Citadelle
2016-2024
University of Liège
2014-2022
Institut de Recherche sur l'Architecture Antique
2019-2021
Centre Hospitalier Universitaire de Bordeaux
2017-2020
Archéorient
2020
Maison de l'Orient et de la Méditerranée Jean Pouilloux
2020
Centre Hospitalier Universitaire de Toulouse
2017-2020
Hôpital Purpan
2014-2020
Recombinant strains of hepatitis E virus (HEV) with insertions human genomic fragments or HEV sequence duplications in the encoding polyproline region (PPR) were previously described chronically infected patients. Such rearrangements confer a replicative advantage vitro but little is known about their frequency, location, origin. As sequences only few genomes are available, we analyzed complete 114 genotype 3 from immunocompromised (n = 85) and immunocompetent 29) patients using single...
Abstract Background: Fibroblast growth factor receptors (FGFRs) play a role in cell proliferation and survival. Genetic alterations of FGFRs can lead to deregulated activation various cancers, including squamous carcinoma (SCC) the lung urothelial bladder cancer. Here, we report on phase I study BGJ398 potent, selective pan-FGFR inhibitor. Methods: Eligible patients (pts; ≥ 18 years age) had tumors with any FGFR genetic alteration identified by central or local prescreening. Pts received...
ABSTRACT Hepatitis E virus (HEV) can lead to chronic infection in solid-organ transplant patients. Ribavirin is efficient for treatment of chronically infected Recently, the1634R mutation the HEV polymerase has been associated with failure. However, it unclear if this be used as a prognostic marker outcome. We studied prevalence 1634R patients starting ribavirin therapy, influence variants on viral response, frequency whose failed, and its impact retreatment. analyzed pretreatment samples...
<title>Abstract</title> Breast cancer-associated fibroblasts (bCAFs) comprise inflammatory CAFs (iCAFs), characterized by the secretion of pro-inflammatory cytokines, and myofibroblastic (myCAFs), distinguished their high production extracellular matrix immunosuppressive properties. We previously showed that targeting anti-apoptotic protein MCL-1 in primary culture bCAF derived directly from human samples reduces characteristics. herein show single-cell RNA-sequencing analysis bCAFs knock...
Hepatitis E virus genotype 3 (HEV-3) can lead to chronic infection in immunocompromised patients, and ribavirin is the treatment of choice. Recently, mutations polymerase gene have been associated with failure but their frequency before according HEV-3 subtypes has not studied on a large data set. We used single-molecule real-time sequencing technology sequence 115 new complete genomes infecting French patients. analyzed phylogenetic relationships, length polyproline region, HEV gene....
8034 Background: Identifying molecular drivers in lung squamous cell carcinoma (SCC) is a major medical need since no targeted therapy available yet for this subtype. Fibroblast growth factor receptors (FGFRs) are physiologically involved proliferation and survival. Genetic alteration of FGFR genes leads to deregulated activation various cancers, FGFR1 amplification has been detected SCC. Here, we report on patients (pts) with FGFR1-amplified SCC treated phase 1 study BGJ398, potent,...
Abstract Background Non alcoholic fatty liver disease (NAFLD) results from alteration in lipid synthesis and elimination mechanisms such as very-low density lipoprotein (VLDL) production de novo lipogenesis. Persistent organic pollutants (POPs) are chemicals that were mostly used historically pesticides, solvents, flame retardant, other applications. Among POPs, polychlorinated biphenyls (PCB) have been recognized to be of environmental potential toxicologic concerns. Specifically, PCB126...
// Anthony Kong 1, 2 , Daniel Rea Samreen Ahmed 3 J. Thaddeus Beck 4 Rafael López 5 Laura Biganzoli 6 Anne C. Armstrong 7 Massimo Aglietta 8 Emilio Alba 9 Mario Campone 10 Shu-Fang Hsu Schmitz 11 Caroline Lefebvre 12 Mikhail Akimov 13 Soo-Chin Lee 14 1 Previous address: Churchill Hospital, Oxford University Hospitals NHS Trust and of Oxford, United Kingdom School Cancer Sciences, Birmingham, Department Oncology, Leicester, Leicester Royal Infirmary, Highlands Oncology Group, Fayetteville,...
To evaluate the diagnostic performance of Vela next-generation sequencing (NGS) system in conjunction with Sentosa SQ HIV Genotyping Assay for genotyping HIV-1. Plasma RNA was extracted and templates prepared SX instrument before HIV-1 polymerase on SQ301 Sequencer (PGM IonTorrent). The NGS System compared direct 454 GS-FLX (Roche) MiSeq (Illumina) systems genotypic resistance testing clinical samples. detected majority mutations subtype B CRF02-AG samples at 500 copies/mL minority variants...
Abstract The coreceptor used by HIV-1 must be determined before a CCR5 antagonist, part of the arsenal antiretroviral drugs, is prescribed because viruses that enter cells using CXCR4 are responsible for treatment failure. tropism also correlated with disease progression and so virological studies. Tropism can next-generation sequencing (NGS), but not all these new technologies have been fully validated use in clinical practice. Illumina NGS technology many laboratories its ability to...
Abstract HIV-1 coreceptor usage must be accurately determined before starting CCR5 antagonist-based treatment as the presence of undetected minor CXCR4-using variants can cause subsequent virological failure. Ultra-deep pyrosequencing V3 env allows to detect low levels that current genotypic approaches miss. However, computation mass sequence data and need identify true while excluding artifactual sequences generated during amplification ultra-deep is rate-limiting. Arbitrary fixed cut-offs...
530 Background: AUY922 is a novel HSP90 inhibitor that causes degradation of oncogenic proteins. A Phase I study in advanced solid tumors gave recommended II dose (RP2D) 70 mg/m 2 . In the part study, single-agent showed preliminary activity HER2+ metastatic breast cancer (mBC) (Schröder et al ASCO 2011). This Ib/II assessed safety and efficacy + trastuzumab (T) pts with T-refractory advanced/mBC. Methods: Pts BC (ECOG PS ≤1) who progressed on 1–2 prior anti-HER2 regimens at least 1...
The present study compares the performances of an in-house sequencing protocol developed on MiSeq, Sanger method, and 454 GS-FLX for detecting quantifying drug-resistant mutations (DRMs) in human immunodeficiency virus polymerase gene (reverse transcriptase [RT] protease [PR]). MiSeq identified all resistance detected by bulk (n = 84). Both platforms 67 DRMs RT PR regions, but a further 25 were only one or other them. Pearson's analysis showed good concordance between percentage variants...