A5000614492- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- SARS-CoV-2 detection and testing
- Hepatitis Viruses Studies and Epidemiology
- COVID-19 epidemiological studies
- Liver Disease and Transplantation
- Viral gastroenteritis research and epidemiology
- Respiratory viral infections research
- Bariatric Surgery and Outcomes
- Liver Diseases and Immunity
- Viral Infections and Outbreaks Research
- Animal Virus Infections Studies
- HIV Research and Treatment
- Bayesian Modeling and Causal Inference
- HIV/AIDS Research and Interventions
- Influenza Virus Research Studies
- HIV/AIDS drug development and treatment
- Morphological variations and asymmetry
- COVID-19 and Mental Health
- Obesity and Health Practices
- COVID-19 Pandemic Impacts
- Body Contouring and Surgery
- Healthcare Systems and Practices
- 3D Shape Modeling and Analysis
- Long-Term Effects of COVID-19
Inserm
2016-2025
Centre National de la Recherche Scientifique
2018-2025
Hôpital Purpan
2018-2024
Université Toulouse III - Paul Sabatier
2013-2024
Université de Toulouse
2015-2024
Centre Hospitalier Universitaire de Toulouse
2015-2023
Institut Toulousain des Maladies Infectieuses et Inflammatoires
2020-2023
Deleted Institution
2023
Institut de Virologie
2019-2022
Centre de Physiopathologie de Toulouse-Purpan
2019-2021
Recombinant strains of hepatitis E virus (HEV) with insertions human genomic fragments or HEV sequence duplications in the encoding polyproline region (PPR) were previously described chronically infected patients. Such rearrangements confer a replicative advantage vitro but little is known about their frequency, location, origin. As sequences only few genomes are available, we analyzed complete 114 genotype 3 from immunocompromised (n = 85) and immunocompetent 29) patients using single...
Most cases of hepatitis E viral (HEV) infection in developed countries are autochthonous. Nevertheless, the reported seroprevalence HEV varies greatly depending on geographical area and performance immunoassay used. We used validated assays to determine prevalence anti‐HEV immunoglobulin G (IgG) IgM among 10,569 French blood donors living mainland France three overseas areas. Epidemiological information was collected using a specific questionnaire. found an overall IgG 22.4% (8%‐86.4%) ( P...
Hepatitis E virus (HEV) genotype 3 is the most common linked to HEV infections in Europe and America. Three major clades (HEV-3.1, HEV-3.2, HEV-3.3) have been identified but overlaps between intra-subtype inter-subtype p-distances make subtype classification inconsistent. Reference sequences proposed facilitate communication researchers new putative subtypes recently. We used full or near full-length HEV-3 genome available Genbank database (April 2020; n = 503) distance analyses of HEV-3.1...
The emergence of the SARS-CoV-2 variants concern has greatly influenced immune correlates protection, and there are little data about antibody threshold concentrations to protect against infection with Omicron BA.1 or BA.2. We analyzed responses 259 vaccinated healthcare workers, some whom had been previously infected by SARS-CoV-2. median follow-up was 179 days (IQR: 171-182) after blood collection. detected 88 infections during period, 55 (62.5%) BA.1, 33 (37.5%) A neutralizing titer below...
Hepatitis E virus is a single-strand, positive-sense RNA that can lead to chronic infection in immunocompromised patients. Virus-host recombinant variants (VHRVs) have been described such These integrate part of human genes into the polyproline-rich region could introduce new post-translational modifications (PTMs), as ubiquitination. The aim this study was characterize replication capacity different VHRVs, namely, RNF19A, ZNF787, KIF1B, EEF1A1, RNA18, RPS17, and RPL6. We used plasmid...
Recent zoonotic disease emergences reveal the importance of studying wildlife parasite communities. As wild hosts frequently harbour diverse species, understanding drivers multiple infection patterns in free-ranging is critical for elucidating ecological and epidemiological dynamics In this study, we analysed co-infection European roe deer (Capreolus capreolus) inhabiting a fragmented rural landscape southwestern France. Using data from 130 GPS-tracked deer, examined influence proximity to...
Epidemiologists often handle large datasets with numerous variables and are currently seeing a growing wealth of techniques for data analysis, such as machine learning. Critical aspects involve addressing causality, based on observational data, dealing the complex relationships between to uncover overall structure variable interactions, causal or not. Structure learning (SL) methods aim automatically semi-automatically reveal variables’ relationships. The objective this study is delineate...
Collisions with large vessels potentially present a major conservation issue for sperm whales in the Pelagos Sanctuary northwestern Mediterranean Sea. The exact numbers and locations of ship strikes remain largely unknown at present. In this study, sightings summer (June–September) were gathered period between 1998 2008 from nine French Italian organisations, together covering an area more than 68,000km. Working on regular grid 0.1° × latitude/longitude cells, approximate surface density was...
Hepatitis E virus genotype 3 (HEV-3) is a major aetiologic agent of acute hepatitis in industrialized countries. Two main HEV-3 subtypes are found Europe: 3c and 3f. We have analysed the clinical biological parameters from 100 French immunocompetent patients with an HEV subtype 3f or infection, included prospective multicentre study. Stepwise regression analysis that infections were associated fever (OR: 6.1 95%CI: 1.4-26.1), greater load 7.4; 1.3-42.2) require more frequent hospitalization...
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in December 2019 and caused a dramatic pandemic. Serological assays are used to check for immunization assess herd immunity.
The present study aimed to determine whether current commercial immunoassays are adequate for detecting anti-Omicron antibodies. We analyzed the anti-SARS-CoV-2 antibody response of 23 unvaccinated individuals 1-2 months after an Omicron infection. All blood samples were tested with a live virus neutralization assay using clinical BA.1 strain and four SARS-CoV-2 immunoassays. assessed three anti-Spike (SARS-CoV-2 IgG II Quant [Abbott S], Wantaï ELISA [Wantaï], Elecsys Anti-SARS-CoV-2 S...
Studies comparing SARS-CoV-2 nasopharyngeal (NP) viral load (VL) according to virus variant and host vaccination status have yielded inconsistent results. We conducted a single center prospective study between July September 2021 at the drive-through testing of Toulouse University Hospital. compared NP VL 3775 patients infected by Delta (
Abstract New variants and genetic mutations of the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) genome can only be identified using accurate sequencing methods. Single molecule real‐time (SMRT) has been used to characterize Alpha Delta variants, but not Omicron harboring numerous in SARS‐CoV‐2 genome. This study assesses performance a target capture SMRT protocol for whole (WGS) compared it that an amplicon optimized variants. The failure rate (6%) was lower than (34%, p <...