A5044343606- Renal Diseases and Glomerulopathies
- Birth, Development, and Health
- Pediatric Urology and Nephrology Studies
- Chronic Kidney Disease and Diabetes
- Dialysis and Renal Disease Management
- Kidney Stones and Urolithiasis Treatments
- Renal Transplantation Outcomes and Treatments
- Vasculitis and related conditions
- Electrolyte and hormonal disorders
- Renal and related cancers
- Complement system in diseases
- Urological Disorders and Treatments
- Biomedical Research and Pathophysiology
- Diet and metabolism studies
- Healthcare Systems and Technology
- Genetic and Kidney Cyst Diseases
- Adolescent and Pediatric Healthcare
- Neonatal Health and Biochemistry
- Renal and Vascular Pathologies
- Metabolism and Genetic Disorders
- Pregnancy and preeclampsia studies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Inflammasome and immune disorders
- Health, Medicine and Society
University of Lausanne
2015-2024
University Hospital of Lausanne
2014-2023
Pediatric Nephrology of Alabama
2013-2020
University Hospital of Geneva
2012-2019
Hôpital Orthopédique de la Suisse Romande
2014-2018
Boston Children's Hospital
2010
Proteinuria and hyperphosphatemia are cardiovascular risk factors independent of GFR. We hypothesized that proteinuria induces relative phosphate retention via increased proximal tubule reabsorption. To test the clinical relevance this hypothesis, we studied handling in nephrotic children patients with CKD. Plasma fibroblast growth factor 23 (FGF-23) concentration, plasma tubular reabsorption during proteinuric phase compared remission children. Cross-sectional analysis a cohort 1738 CKD...
<h3>Background and objective</h3> Urinary tract infection (UTI) represents the most common bacterial in infants, its prevalence increases with presence of high-grade vesicoureteral reflux (VUR). However, voiding cystourethrography (VCUG) is invasive, indication infants <3 months not yet defined. This study aims to investigate, aged 0–3 months, if <i>Escherichia coli</i> versus non-<i>E. bacteria and/or normal or abnormal renal ultrasound (US) could avoid use VCUG. <h3>Method</h3> One...
We report on successful early eculizumab administration to treat acute antibody-mediated rejection (ABMR) in a highly sensitized kidney transplant recipient. The recipient is 7-year-old boy who received, 6 months after desensitization protocol with monthly intravenous immunoglobulin infusion, second the presence of low donor-specific antibodies (DSAs). Both pretransplant lymphocytotoxic and flow cytometric crossmatch were negative. Allograft function recovered promptly, excellent initial...
Summary Background and objectives The estimated GFR (eGFR) is important in clinical practice. To find the best formula for eGFR, this study assessed model of correlation between sinistrin clearance (iGFR) solely or combined cystatin C (CysC)– serum creatinine (SCreat)–derived models. It also evaluated accuracy Schwartz across all levels. Design, setting, participants, & measurements Two hundred thirty-eight iGFRs performed January 2012 April 2013 238 children were analyzed. Regression...
Heart diseases are a leading cause of death. While the link between early exposure to nutritional excess and heart disease risk is clear, molecular mechanisms involved poorly understood. In developmental programming field, increasing evidence pointing out critical role epigenetic mechanisms. Among them, polycomb repressive complex 2 (PRC2) DNA methylation play in development pathogenesis. this context, we aimed at evaluating these marks long-term cardiac alterations induced by dietary...
Heart failure is a worldwide leading cause of death. Diet and obesity are particularly high concern in heart disease etiology. Gravely, altered nutrition during developmental windows vulnerability can have long-term impact on health; however, the underlying mechanisms poorly understood. In understanding initiation chronic diseases related to exposure environmental challenges, deregulations epigenetic including micro-RNAs been proposed as key events. this context, we aimed at delineating role...
Impaired early nutrition influences the risk of developing metabolic disorders in later life. We observed that transient postnatal overfeeding (OF) mice induces long-term hepatic alterations, characterized by microsteatosis, fibrosis associated with oxidative stress (OS), and stress-induced premature senescence (SIPS). In this study, we investigated whether such changes can be reversed moderate calorie restriction (CR). C57BL/6 male pups were maintained during lactation litters adjusted to...
Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disorder characterized by numerous fluid-filled cysts that frequently result in end-stage renal disease. While promising treatment options are advanced clinical development, early diagnosis and follow-up remain major challenge. We therefore evaluated the diagnostic value of Fetuin-A as new biomarker ADPKD human urine.We found levels upregulated both Pkd1 Bicc1 mouse models ADPKD. Measurement ELISA revealed urinary were...
As outcome data for prune belly syndrome (PBS) complicated by end-stage renal disease are scarce, we analyzed characteristics and outcomes of children with PBS using the European Society Pediatric Nephrology/European Renal Association-European Dialysis Transplant Association (ESPN/ERA-EDTA) Registry data.Data were available 88 male patients aged <20 years who started replacement therapy (RRT) between 1990 2013 in 35 countries. Patient characteristics, survival, transplantation compared those...
Clinical manifestations of vitamin D deficiency rickets are widely described; however cardiorespiratory arrest is an extremely rare presentation.The aim this paper to present the symptoms severe and highlight importance prophylaxis in infants.We report a case 16-month-old infant who presented emergency room with stridor that evolved into full secondary hypocalcemia. Medical history revealed was exclusively breastfed without supplementation until age 10 months. Due cultural habits, his diet...
The combined serum creatinine (SCreat) and cystatin C (CysC) CKD-EPI formula constitutes a new advance for glomerular filtration rate (GFR) estimation in adults. Using inulin clearances (iGFRs), the revised SCreat Schwartz formulas, this study aims to evaluate applicability of children.201 iGFRs 201 children were analyzed divided by chronic kidney disease (CKD) stages (iGFRs ≥90 ml/min/1.73 m(2), 90 > 60, ≤59), age groups (<10, 10-15, >15 years). Medians with 95% confidence intervals bias,...