A5000463170- Biomedical Research and Pathophysiology
- Neonatal Health and Biochemistry
- Vitamin D Research Studies
- Pediatric Urology and Nephrology Studies
- Parathyroid Disorders and Treatments
- Acute Kidney Injury Research
- Renal Diseases and Glomerulopathies
- Birth, Development, and Health
- Vasculitis and related conditions
- Kidney Stones and Urolithiasis Treatments
- Dialysis and Renal Disease Management
- Genetic and Kidney Cyst Diseases
- Muscle and Compartmental Disorders
- Chronic Kidney Disease and Diabetes
- Neonatal Respiratory Health Research
- Vitamin C and Antioxidants Research
- Electrolyte and hormonal disorders
- Organ Donation and Transplantation
- Amino Acid Enzymes and Metabolism
- Inflammasome and immune disorders
- Pharmaceutical Practices and Patient Outcomes
- Bone health and osteoporosis research
- Blood groups and transfusion
- Autoimmune Neurological Disorders and Treatments
- Renal and related cancers
University Hospital of Geneva
2012-2024
Hôpital Beau-Séjour
2023
Geneva College
2021
Hôpital des Enfants
2019
University of Geneva
2011
Neonatal primary hyperparathyroidism (NPHT) is associated with an inactivating homozygous mutation of the calcium sensing receptor (CaSR). The CaSR expressed most abundantly in parathyroid glands and kidney regulates homeostasis through its ability to modulate parathormone secretion renal reabsorption. NPHT leads life threatening hypercalcemia, nephrocalcinosis, bone demineralization, neurologic disabilities. Surgery treatment choice. While waiting for surgery, bisphosphonates offer a good...
Proteinuria and hyperphosphatemia are cardiovascular risk factors independent of GFR. We hypothesized that proteinuria induces relative phosphate retention via increased proximal tubule reabsorption. To test the clinical relevance this hypothesis, we studied handling in nephrotic children patients with CKD. Plasma fibroblast growth factor 23 (FGF-23) concentration, plasma tubular reabsorption during proteinuric phase compared remission children. Cross-sectional analysis a cohort 1738 CKD...
The current threshold used for oliguria in the definition of neonatal AKI has been empirically defined as 1 ml/kg per hour. Urine output criteria are generally poorly documented, resulting uncertainty most accurate to identify very preterm infants with known tubular immaturity.We conducted a bicentric study including 473 (240/7-296/7 weeks gestation) born between January 2014 and December 2018 urine measurements every 3 hours during first 7 days life two serum creatinine 10 life. was using...
Albuminuria is strongly associated with renal and cardiovascular outcomes independently of function level. However, the pathophysiology these associations debated. In chronic kidney disease (CKD), phosphate retention participates in events increased mortality. We hypothesised that albuminuria may modulate tubular handling by kidney. To verify this hypothesis, we first studied association between phosphataemia children nephrotic syndrome adults CKD. both cases, higher was level, glomerular...
Cholecalciferol (vitamin D3) is essentially known for its role in the phosphocalcic metabolism and associated pathologies, such as rickets. In Switzerland, 35 to 50% of children are vitamin D deficient. Due skin colour, poor nutrition, living conditions cultural practices, migrant population particularly at risk. Our aim attest prevalence hypovitaminosis arriving Switzerland. We retrospectively assessed 528 children's status parathyroid hormone, phosphate calcium levels between 2015 2018 by...
Background: Autosomal Dominant Polycystic Kidney Disease (ADPKD) is increasingly diagnosed during childhood by the presence of renal cysts in patients with a positive familial history. No curative treatment available and early detection diagnosis confronts pediatricians lack markers to decide whether nephroprotective should be introduced prevent progression failure. Neutrophil Gelatinase-Associated Lipocalin (NGAL) tubular protein that has been recently proposed as an biomarker impairment...
Neutrophil gelatinase-associated lipocalin (NGAL) has been proposed as an early acute kidney injury (AKI) biomarker in the neonatal population. Our goal is to describe this behavior high-risk population, absence of AKI confirmed by inulin clearance.Prospective study including 42 preterm newborns (mean gestational age: 30.7 ± 2.3 weeks) with a urinary NGAL collection between day 1 and 6 life.Median neutrophil (uNGAL) value 122.8 ng/ml (7-1981.5 ng/ml). Statistically significant higher uNGAL...
The premature has a reduced number of nephrons. This condition, added to an immature renal function at birth, increases the vulnerability hemodynamic changes, drug toxicity, and nephrocalcinosis. oligonephronia worsens risk present in adulthood, hypertension insufficiency. Nephrocalcinosis appears postnatal period, secondary calcifications. condition further endowment. nephrocalcinosis is closely related rickets premature. Indeed, excess vitamin D calcium, early recognition markers, such as...
In patients with solitary kidney, either congenital or acquired, compensatory mechanisms come into play to maintain renal function, such as glomerular hyperfiltration and hypertrophy renin-angiotensin-aldosterone system activation. the long term, these lead arterial hypertension then chronic kidney disease. The risk of is greater in cases single nephrectomy childhood than adulthood. Having a increases gestational pre-eclampsia. Antihypertensive treatment based on Angiotensin-converting...
Objective To evaluate whether urine output (UO), rarely assessed in the literature, is associated with relevant neonatal outcomes very preterm infants, and which UO threshold may be most clinically relevant. Design Retrospective cohort study. Setting Two Level IV intensive care units. Patients Very infants born between 24 0/7 29 6/7 weeks of gestation documented eight measurements per day postnatal 1 7. Main outcome measures Composite defined as death before discharge, or moderate to severe...