A5010301379- Birth, Development, and Health
- Pregnancy and preeclampsia studies
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Neonatal Respiratory Health Research
- Gestational Diabetes Research and Management
- Infant Nutrition and Health
- Anesthesia and Neurotoxicity Research
- Renal and related cancers
- Nitric Oxide and Endothelin Effects
- Sirtuins and Resveratrol in Medicine
- Cardiovascular Health and Disease Prevention
- Fatty Acid Research and Health
- Epigenetics and DNA Methylation
- Clinical Nutrition and Gastroenterology
- RNA Interference and Gene Delivery
- Apelin-related biomedical research
- Childhood Cancer Survivors' Quality of Life
- Breastfeeding Practices and Influences
- Extracellular vesicles in disease
- Biochemical effects in animals
- Cancer, Hypoxia, and Metabolism
- Neonatal Health and Biochemistry
- Diabetes Management and Research
- Renin-Angiotensin System Studies
University of Lausanne
2015-2025
University Hospital of Lausanne
2017-2023
Hôpital de l'enfance
2018
Pulmonary Vascular Research Institute
2016
Unité de Nutrition Humaine
2011-2015
Université de Montréal
2006-2014
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2012
Centre Hospitalier Universitaire Sainte-Justine
2006-2012
Centre de Recherche en Nutrition Humaine d'Auvergne
2012
Inserm
2008
Developmental programming of hypertension is associated with vascular dysfunction characterized by impaired vasodilatation to nitric oxide, exaggerated vasoconstriction ANG II, and microvascular rarefaction appearing in the neonatal period. Hypertensive adults have indices increased oxidative stress, newborns that were nutrient depleted during fetal life decreased antioxidant defenses susceptibility oxidant injury. To test hypothesis stress participates early hypertension, dysfunction,...
Intrauterine growth restriction (IUGR) affects 10-15% of all pregnancies worldwide. IUGR may result from maternal, placental or fetal origin. Maternal malnutrition before and during pregnancy represents the most prevalent non-genetic cause. reflects an abnormal adaptive in a deleterious environment. Individuals born after are more susceptible to develop diseases related subsequent stressors through lifetime. Animal models help decipher underlying causes dysregulated pathways molecular...
Long-term vascular and renal consequences of neonatal oxidative injury are unknown. Using a rat model, we sought to investigate whether function blood pressure altered in adult rats exposed hyperoxic conditions as neonates. We also questioned O 2 causes long-term damage, important the pathogenesis hypertension. Sprague-Dawley pups were kept with their mother 80% or room air from days 3 10 postnatal, was measured (tail cuff) weeks 7 15. Rats euthanized, reactivity (ex vivo carotid rings),...
Preterm neonates are exposed at birth to high oxygen concentrations relative the intrauterine environment. We have previously shown in a rat model that hyperoxic insult results reduced nephron number adulthood. Therefore, aim of this study was determine effects transient neonatal hyperoxia exposure on nephrogenesis. Sprague-Dawley pups were raised 80% O2 or room air from P3 P10. Pups (n = 12/group, 6 males and females) sacrificed P5 (during active nephrogenesis) P10 (after completion...
Abstract A large body of evidence suggests that intrauterine growth restriction (IUGR) impedes normal neurodevelopment and predisposes the offspring to cognitive behavioral deficits later in life. significantly higher risk rate for schizophrenia (SZ) has been reported individuals born after IUGR. Oxidative stress neuroinflammation are both involved pathophysiology SZ, particularly affecting structural functional integrity parvalbumin interneurons (PVI) their perineuronal nets (PNN). These...
The renin-angiotensin system plays a key role in the initiation and maintenance of elevated blood pressure associated with altered intrauterine milieu. current studies were undertaken to verify whether vascular response ANG II is increased adult offspring low-protein fed dams (LP) compared control (CTRL) if so, examine underlying mechanism(s). II-induced contraction carotid rings was LP (E(max), maximum asymptote curve, relative maximal KCl 80 mM: 230 +/- 3% vs. 201 2% CTRL, P < 0.05). In...
Individuals born after intrauterine growth restriction (IUGR) are at increased risk of developing cardiovascular diseases in adulthood, notably hypertension (HTN). Alterations the vascular system, particularly impaired endothelium-dependent vasodilation, may play an important role long-term effects IUGR. Whether such dysfunction precedes HTN has not been fully established individuals Moreover, intimate mechanisms altered vasodilation remain incompletely elucidated. We therefore investigated,...
Neonatal high-oxygen exposure leads to elevated blood pressure, microvascular rarefaction, vascular dysfunction and arterial (aorta) rigidity in adult rats. Whether structural changes are present the matrix of aorta wall is unknown. Considering that elastin synthesis peaks late fetal life humans, early postnatal rodents, we postulated transient neonatal can trigger premature remodelling. Sprague Dawley rat pups were exposed from days 3 10 after birth 80% oxygen (vs. room air control) studied...
Impaired early nutrition influences the risk of developing metabolic disorders in later life. We observed that transient postnatal overfeeding (OF) mice induces long-term hepatic alterations, characterized by microsteatosis, fibrosis associated with oxidative stress (OS), and stress-induced premature senescence (SIPS). In this study, we investigated whether such changes can be reversed moderate calorie restriction (CR). C57BL/6 male pups were maintained during lactation litters adjusted to...
The authors have previously shown that neonatal hyperoxic stress leads to high blood pressure, impaired endothelium-mediated vasodilatation, and increased vascular production of superoxide anion by NAD(P)H oxidase in adulthood. However, it is unknown whether changes nitric oxide (NO) and/or bioinactivation prevail NO synthase (NOS) also a source superoxide. purpose this study was evaluate adult animals exposed associated with NOS uncoupling participating dysfunction. In male rats 80% oxygen...
Aim: The Developmental Origin of Health and Disease refers to the concept that early exposure toxicants or nutritional imbalances during perinatal life induces changes enhance risk developing noncommunicable diseases in adulthood. Patients/materials & methods: An experimental model with an adult chronic germ cell death phenotype resulting from a xenoestrogen was used. Results: A reciprocal negative feedback loop involving decreased EZH2 protein level increased miR-101 expression identified....
Metabolic syndrome (MetS) refers to cardiometabolic risk factors, such as visceral obesity, dyslipidemia, hyperglycemia/insulin resistance, arterial hypertension and non-alcoholic fatty liver disease (NAFLD). Individuals born after intrauterine growth restriction (IUGR) are particularly at of developing metabolic/hepatic disorders later in life. Oxidative stress cellular senescence have been associated with MetS observed infants following IUGR. However, whether these mechanisms could be the...
Unbalanced nutrition early in life is increasingly recognized as an important factor the development of chronic, non-communicable diseases at adulthood, including metabolic diseases. We aimed to determine whether transient postnatal overfeeding (OF) leads liver stress-induced premature senescence (SIPS) hepatocytes association with structure and hepatic function alterations. Litters sizes male C57BL/6 mice were adjusted 9 pups (normal feeding, NF) or reduced 3 during lactation period induce...
Early nutrition influences the risk of chronic kidney diseases (CKDs) development in adulthood. Mechanisms underlying early programming altered renal function remain incompletely understood. This study aims at characterizing role cell senescence pathways CKD after transient postnatal overfeeding.Reduced litters 3 mice pups and standard 9 were obtained to induce overfed animals during lactation control animals, respectively. Animals sacrificed 24 days (weaning) or 7 months life (adulthood)....
We have previously shown that neonatal high oxygen (O2) exposure in rats leads to hypertension and vascular dysfunction adulthood. Pulse-wave velocity (PWV), an indirect measure of biophysical properties (arterial stiffness or distensibility), is a sensitive marker cardiovascular health. Its measurement mostly based on invasive hemodynamics measurements, prohibiting longitudinal studies particularly relevant models developmental programming dysfunctions. With this study, we sought (1) verify...
Individuals born after intrauterine growth restriction (IUGR) are at risk of developing cardiovascular diseases (CVDs). Endothelial dysfunction plays a role in the pathogenesis CVDs; and endothelial colony-forming cells (ECFCs) have been identified as key factors repair. In rat model IUGR induced by maternal low-protein diet, we observed an altered functionality ECFCs 6-month-old males, which was associated with arterial hypertension related to oxidative stress stress-induced premature...
Abstract Early malnutrition, the first environmental cause of intra-uterine growth restriction, impairs development thymus. Alterations thymic structure and function are reported at young ages in murine ovine models. However, descriptions consequences fetal malnutrition adulthood scarce. The present study investigates structure, protein expression cell selection process observed postnatal day 180 (PND180) male offspring rats exposed to maternal low-protein diet (mLPD) compared with control...