A5102952445- Birth, Development, and Health
- Neonatal Respiratory Health Research
- Pregnancy and preeclampsia studies
- Congenital Heart Disease Studies
- Anesthesia and Neurotoxicity Research
- Cardiovascular Function and Risk Factors
- Infant Development and Preterm Care
- Cardiovascular Health and Disease Prevention
- Fatty Acid Research and Health
- Neonatal and fetal brain pathology
- Respiratory Support and Mechanisms
- Cardiovascular Disease and Adiposity
- Pharmaceutical studies and practices
- Cardiovascular and exercise physiology
- Infant Nutrition and Health
- Receptor Mechanisms and Signaling
- Neuroscience of respiration and sleep
- Cardiac electrophysiology and arrhythmias
- Adipose Tissue and Metabolism
- Clinical Nutrition and Gastroenterology
- Mitochondrial Function and Pathology
- Infant Health and Development
- Gestational Diabetes Research and Management
- Attachment and Relationship Dynamics
- Metabolism and Genetic Disorders
Centre Hospitalier Universitaire Sainte-Justine
2014-2024
Université de Montréal
2015-2024
Karolinska Institutet
2024
Nationwide Children's Hospital
2024
Maine Medical Center
2024
Université Laval
2020
Salford Royal NHS Foundation Trust
2020
Jewish General Hospital
2013-2016
McGill University
2013-2016
Montreal Children's Hospital
1979
Preterm birth incurs a higher risk for adult cardiovascular diseases, including hypertension. Because preterm may impact nephrogenesis, study objectives were to assess renal size and function of adults born versus full term examine their relationship with blood pressure (BP; 24-hour ambulatory BP monitoring) circulating renin-Ang (angiotensin) system peptides. The included 92 young (1987–1997) (≤29 weeks gestation) (n=92) matched age, sex, race. Young had smaller kidneys (80±17 90±18 cm 3 /m...
It remains uncertain whether maternal IGF-I is associated with fetal growth. Little known about the role of IGF-II in growth and or implicated hypertrophy gestational diabetes.The objective study was to assess levels association diabetes. STUDY DESIGN, POPULATION, AND OUTCOMES: A singleton pregnancy cohort (n = 307). The primary outcome birth weight.Maternal plasma concentrations increased by an average 55.4% for 11.8% between 24-28 32-35 weeks gestation. but not level correlated weight...
Perinatal conditions (such as preterm birth) can affect adult health and disease, particularly the cardiovascular system. Transient neonatal high O 2 exposure in rat adulthood (a model of birth–related complications) leads to elevated blood pressure, vascular rigidity, dysfunction with renin–angiotensin system activation. We postulate that hyperoxic stress also affects myocardial structure, function, expression components. Sprague-Dawley pups were kept their mother 80% or room air (control)...
Preterm neonates are exposed at birth to high oxygen concentrations relative the intrauterine environment. We have previously shown in a rat model that hyperoxic insult results reduced nephron number adulthood. Therefore, aim of this study was determine effects transient neonatal hyperoxia exposure on nephrogenesis. Sprague-Dawley pups were raised 80% O2 or room air from P3 P10. Pups (n = 12/group, 6 males and females) sacrificed P5 (during active nephrogenesis) P10 (after completion...
Preterm birth incurs an increased risk of early cardiovascular events and death. In the general population, factors cluster in context inflammation oxidative stress. Whether this also occurs young adults born preterm is unknown. We analyzed 101 healthy (ages 18–29) (≤29 weeks gestation) 105 full-term controls, predominantly (90%) white. They underwent a comprehensive clinical biological evaluation, including measurement blood pressure, lung function (spirometry), glucose metabolism (fasting...
Objective: Preterm birth has been associated with changes in arterial structure and function. Association complications occurring during the neonatal period, including bronchopulmonary dysplasia, on vascular outcomes adulthood is unknown. Approach Results: We evaluated a cohort of 86 adults born preterm (below 30 weeks gestation), compared to 85 term, at mean age 23 years. performed ultrasonographic assessment dimensions ascending aorta, carotid brachial arteries, estimated flow-mediated...
Preterm infants are at increased risk of osteopenia prematurity due to insufficient bone mineral accretion. Data on long term effects health conflicting. This study aimed compare density (BMD) in young adults born very preterm and full-term controls examine factors associated with long-term health. observational cross-sectional enrolled 101 (18–29 years) <29 weeks gestation 95 sex- age-matched controls. Participants underwent dual-energy X-ray absorptiometry measure areal BMD body...
Newborn rats exposed to high oxygen (O2), mimicking preterm birth-related neonatal stress, develop later in life cardiac hypertrophy, dysfunction, fibrosis, and activation of the renin-angiotensin system. Cardiac system O2-exposed adult is characterized by an imbalance angiotensin (Ang) receptors type 1/2 (AT1/2), with prevailing AT1 expression. To study role developmental programming we assessed Ang receptor expression during O2 exposure whether blockade prevents alterations early...
Preterm birth is linked to cardiovascular risks and diseases. Endothelial progenitor cells play a critical role in vascular development repair. Cord blood endothelial of preterm-born infants, especially colony-forming (ECFC), show enhanced susceptibility prematurity-related pro-oxidant stress. Whether ECFC dysfunction present adulthood following preterm unknown.
Preterm birth is associated with proinflammatory conditions and alterations in adult cardiac shape function. Neonatal exposure to high oxygen, a rat model of prematurity-related conditions, leads remodeling, fibrosis, dysfunction. TLR (Toll-like receptor) 4 signaling critical link between oxidative stress, inflammation, the pathogenesis cardiovascular diseases. The current study sought investigate role TLR4 neonatal oxygen-induced cardiomyopathy. Male Sprague-Dawley pups were kept 80% oxygen...
Neonatal high-oxygen exposure leads to elevated blood pressure, microvascular rarefaction, vascular dysfunction and arterial (aorta) rigidity in adult rats. Whether structural changes are present the matrix of aorta wall is unknown. Considering that elastin synthesis peaks late fetal life humans, early postnatal rodents, we postulated transient neonatal can trigger premature remodelling. Sprague Dawley rat pups were exposed from days 3 10 after birth 80% oxygen (vs. room air control) studied...
Adults born preterm are at a higher risk of cardiopulmonary disease and premature death. Preterm birth is associated with abnormalities in right ventricular (RV) structure function, but the impact bronchopulmonary dysplasia (BPD), common complication extremely birth, on these parameters remains unknown. Are BPD alterations RV function early adulthood? Echocardiographic spirometry data were obtained from Health Born Investigation (HAPI). performance evaluated by using echocardiography,...
Preterm birth increases risk of cardiovascular disease and early death. A body evidence suggests left ventricle (LV) echocardiographic alterations in children adults born preterm. We aimed to determine if neonatal characteristics were associated with LV structure function preterm adults. evaluated a cohort 86 young below 30 weeks gestation, 85 full-term controls. determined dimensions using tissue Doppler imaging, conventional speckle tracking echocardiography (STE). Adults had smaller...
This study aims to compare cardiopulmonary response aerobic exercise between young adults born very preterm, including a subgroup with bronchopulmonary dysplasia (BPD), and term controls. Seventy-one (18–29 years) <30 weeks’ gestational age (24 BPD) 73 controls were recruited. Assessment included testing impedance cardiography. We compared group differences in peak O 2 consumption (peak VO ) ventilatory cardiovascular responses using linear regression analyses. Preterm participants had...
Abstract Preterm neonates are prematurely exposed to high oxygen levels at birth which may adversely impact ongoing renal development. The aim of this study was determine the effects neonatal hyperoxia exposure on function and morphology with aging. Sprague Dawley rat pups were raised in a hyperoxic environment (80% oxygen) from P3 P10 during postnatal nephrogenesis. Control litters kept room air ( n = 6–8 litters/group; one male, female/litter/age). Kidney (urine plasma creatinine, sodium,...
Background Although erythropoiesis is impaired and anaemia frequent in neonates born preterm, haematopoiesis adults preterm has not been previously studied. Objective We, thus, aimed to evaluate haemoglobin erythropoietin levels young identify neonatal events associated with adulthood examine the relationships of respiratory function blood pressure. Methods We assessed a cohort 101 (ages 18–29) (≤29 weeks gestation), comparison 105 full-term controls. measured haemoglobin, also using...
We have previously shown that neonatal high oxygen (O2) exposure in rats leads to hypertension and vascular dysfunction adulthood. Pulse-wave velocity (PWV), an indirect measure of biophysical properties (arterial stiffness or distensibility), is a sensitive marker cardiovascular health. Its measurement mostly based on invasive hemodynamics measurements, prohibiting longitudinal studies particularly relevant models developmental programming dysfunctions. With this study, we sought (1) verify...
Background: Inflammation may depress respiration in neonates. This study aimed to establish a link between postimmunization inflammation and cardio-respiratory events (CREs). Methods: Randomized double-blind controlled of infants born < 32 weeks gestation receiving the 2 months vaccine, which comprised diphtheria tetanus toxoids acellular pertussis adsorbed combined with inactivated poliomyelitis vaccines Haemophilus b conjugate pneumococcal 10-valent vaccines. Infants were randomized...
OBJECTIVE Fetal excessive exposure to glucocorticoids may program cardiometabolic risk. Placental 11 β-hydroxysteroid dehydrogenase 2 (11β-HSD2) serves as a barrier prevent fetal overexposure maternal glucocorticoids. It has not been explored whether placental 11β-HSD2 levels are associated with health in postnatal life. RESEARCH DESIGN AND METHODS In prospective birth cohort study of 246 mother-infant pairs, we measured expression and (32–35 weeks gestation) cord plasma cortisol...
Background: Individuals born preterm present left ventricle changes and increased risk of cardiac diseases heart failure. The pathophysiology disease after birth is incompletely understood. Mitochondria dysfunction a hallmark cardiomyopathy resulting in We hypothesized that neonatal hyperoxia rats, recognized model simulating conditions oxygen-induced cardiomyopathy, induce mitochondrial juvenile rats. also humanin, mitochondrial-derived peptide, would be reduced young adults preterm....
Abstract Aim This study assessed the self‐reported health perception and use of care by adults born very preterm before 30 weeks gestation. Methods The participants were part a cross‐sectional observational that global young aged 18–29 years in Quebec, Canada. Health was explored from 2011 to 2016 using second Short‐Form 36 Survey (SF‐36v2), objective measures obtained. Further in‐depth open‐ended questions asked 2018. Results 101 subjects had similar perceptions their 105 term‐born...
Individuals born preterm have reduced aerobic capacity, which could be related to impaired organ development. Their capacity improve with exercise training therefore limited, but this remains unknown. We aimed test an intervention cardiorespiratory fitness in adults preterm.Twenty-one very and 37 full-term individuals aged 18-33 yr took part a 14-wk supervised of cardiovascular, resistance, flexibility (two group one individual sessions per week). Adherence compliance were recorded. Primary...
Abstract Adverse perinatal conditions can lead to developmental programming of cardiovascular diseases. Prematurely born infants are often exposed high oxygen levels, which in animal models has been associated with endothelial dysfunction, hypertension, and cardiac remodeling during adulthood. Here we found that adult mice have transiently O 2 after birth show defective neovasculariation hindlimb ischemia, as demonstrated by impaired blood flow recovery, reduced vascular density ischemic...