A5026291256- Childhood Cancer Survivors' Quality of Life
- Cancer survivorship and care
- Chemotherapy-induced cardiotoxicity and mitigation
- Cardiovascular and exercise physiology
- Cardiovascular Function and Risk Factors
- Glioma Diagnosis and Treatment
- Cardiac electrophysiology and arrhythmias
- Adolescent and Pediatric Healthcare
- Neuroblastoma Research and Treatments
- Acute Lymphoblastic Leukemia research
- Cancer-related cognitive impairment studies
- Family Support in Illness
- Heart Rate Variability and Autonomic Control
- Cardiovascular Effects of Exercise
- Cardiac Imaging and Diagnostics
- Heart Failure Treatment and Management
- Cardiac Ischemia and Reperfusion
- Neurofibromatosis and Schwannoma Cases
- Cancer, Hypoxia, and Metabolism
- Physical Activity and Health
- Nutrition and Health in Aging
- Cardiac Arrest and Resuscitation
- Lymphatic System and Diseases
- Electron Spin Resonance Studies
- Pediatric Pain Management Techniques
Penn State Milton S. Hershey Medical Center
2022-2025
Pennsylvania State University
2022-2025
Centre Hospitalier Universitaire Sainte-Justine
2019-2024
Université de Montréal
2016-2023
Polytechnique Montréal
2021-2023
Université Paris Nanterre
2018-2022
Children's Hospital of Philadelphia
2022
Université Paris Cité
2018-2021
Université du Québec à Montréal
2020
Abstract Background Pediatric low-grade gliomas (PLGG) are the most frequent brain tumors in children. Up to 50% will be refractory conventional chemotherapy. It is now known that majority of PLGG have activation MAPK/ERK pathway. The same pathway also activated plexiform neurofibromas (PNs) which involving peripheral nerves patients with neurofibromatosis type 1 (NF1). These lesions Specific MEK inhibitors such as trametinib available and been approved for other cancers harboring mutations...
Most childhood acute lymphoblastic leukemia (ALL) survivors develop chronic treatment-related adverse effects several years after the end of therapy. A regular practice physical activity and a good cardiorespiratory fitness have potential to reduce risk disease improve quality life. The aim this study was evaluate in cohort ALL survivors, association between or respect guidelines major long-term health outcomes.In total, 247 underwent cardiopulmonary exercise test, completed questionnaire...
Childhood acute lymphoblastic leukemia (cALL) survivors suffer early-onset chronic diseases classically associated with aging. Normal aging is accompanied by organ dysfunctions, including immunological ones. We hypothesize that thymic immunosenescence occurs in cALL and its severity may correlate diseases. The PETALE study a survivor cohort an extensive cardiovascular metabolic evaluation. biomarker, signal joint T-cell receptor excision circles (TREC), was evaluated highly correlated age...
Introduction: As the survival rate of childhood acute lymphoblastic leukemia (ALL) continues to improve, physical deconditioning is becoming an increasingly common problem in survivors. The aim this study was compare cardiorespiratory fitness and activity levels survivors control participants. Methods: A total 221 ALL (114 males 107 females), diagnosed between 1987 2010 treated according Dana Farber Cancer Institute-ALL 87-01 05-01 protocols at Sainte-Justine University Health Center...
Introduction: More than two thirds of survivors have long-term adverse effects, and no study proposes a portrait physical activity level in childhood acute lymphoblastic leukemia survivors. The aims this were to present the cardiorespiratory fitness (CRF) levels detailed overview sedentary activities portrait. Methods: A total 247 included our study. Survivors underwent cardiopulmonary exercise test on ergocycle completed questionnaires assess their leisure daily energy expenditure. Results:...
2042 Background: Pediatric low-grade gliomas (PLGG) are the most frequent brain tumors in children and majority of PLGG have activation MAPK/ERK pathway. Plexiform neurofibromas (PN) found up to 50% patients with neurofibromatosis type 1 (NF1). Trametinib has been used widely treat PN, but no clinical trial reported its efficacy. Methods: This multicenter phase II includes aged ≥ month ≤ 25 years progressing/refractory groups or PN. The primary objective was evaluate overall response rate...
Background: There is limited evidence on the effects of aerobic and resistance training exercise interventions to improve physical function patient-reported outcomes prior autologous allogeneic hematopoietic stem cell transplant (HSCT). IMPROVE-BMT was a single-site, pilot randomized controlled trial investigating feasibility, acceptability, safety pragmatic program HSCT compared usual care. Secondary aims included differences in between group (EX) care control (UC). Methods: Outcome...
Abstract The protective action of remote ischaemic preconditioning (RIPC) has been demonstrated in the context surgical interventions cardiology. Application RIPC to sports performance proposed, but its effect on electrocardiogram (ECG) during exercise remains unknown. This exploratory study aims measure changes ventricular repolarization observed following healthy subjects. In an experimental randomized crossover study, 17 subjects underwent two bouts constant load tests at 75% and 115% gas...
Survivors of childhood acute lymphoblastic leukemia (cALL) are at high risk developing dyslipidemia, including low HDL-cholesterol (HDL-C). This study aimed to examine the associations between food/nutrient intake and levels HDL-C in a cohort children young adult survivors cALL. Eligible participants (n = 241) were cALL (49.4% boys; median age: 21.7 years old) recruited as part PETALE study. Nutritional data collected using validated food frequency questionnaire. Fasting blood was used...