A5055427963- Childhood Cancer Survivors' Quality of Life
- Acute Lymphoblastic Leukemia research
- Cancer-related cognitive impairment studies
- Genetics and Neurodevelopmental Disorders
- Epilepsy research and treatment
- Congenital heart defects research
- Neural dynamics and brain function
- Genomic variations and chromosomal abnormalities
- EEG and Brain-Computer Interfaces
- Neonatal and fetal brain pathology
- Functional Brain Connectivity Studies
- Autism Spectrum Disorder Research
- Fetal and Pediatric Neurological Disorders
- Family Support in Illness
- Advanced Neuroimaging Techniques and Applications
- Infant Development and Preterm Care
- Glioma Diagnosis and Treatment
- Neuroscience and Neuropharmacology Research
- Neurofibromatosis and Schwannoma Cases
- Neuroblastoma Research and Treatments
- Genomics and Rare Diseases
- Advanced MRI Techniques and Applications
- Neurobiology of Language and Bilingualism
- Language Development and Disorders
- Neuroscience and Music Perception
Centre Hospitalier Universitaire Sainte-Justine
2016-2025
Université de Montréal
2016-2025
Cégep Marie-Victorin
2017-2025
Cardiff University
2023
International Laboratory for Brain, Music and Sound Research
2017-2018
Centre de recherche cerveau et cognition
2015
Inserm
2010-2012
Université Paris Cité
2010-2012
Délégation Paris 5
2010-2012
Institut d'Imagerie Biomédicale
2012
The insula is a complex structure involved in wide range of functions. Tracing studies on nonhuman primates reveal array cortical connections the frontal (orbitofrontal and prefrontal cortices, cingulate areas supplementary motor area), parietal (primary secondary somatosensory cortices) temporal (temporal pole, auditory, prorhinal entorhinal lobes. However, recent human tractography have not observed between although these structures are thought to be functionally intimately connected. In...
A number of studies have characterized the changes in variability brain signals with maturation from perspective considering human as a complex system. Specifically, it has been shown that complexity increases development. On one hand, such an increase can be attributed to more specialized and differentiated regions able express higher repertoire mental microstates. other explained by increased integration between widely distributed neuronal populations establishment new connections. The...
Brain development carries with it a large number of structural changes at the local level which impact on functional interactions distributed neuronal networks for perceptual processing. Such enhance information processing capacity, can be indexed by estimation neural signal complexity. Here, we show that during development, EEG complexity increases from one month to 5 years age in response auditory and visual stimulation. However, rates change were not equivalent two responses. Infants'...
Abstract Background Pediatric low-grade gliomas (PLGG) are the most frequent brain tumors in children. Up to 50% will be refractory conventional chemotherapy. It is now known that majority of PLGG have activation MAPK/ERK pathway. The same pathway also activated plexiform neurofibromas (PNs) which involving peripheral nerves patients with neurofibromatosis type 1 (NF1). These lesions Specific MEK inhibitors such as trametinib available and been approved for other cancers harboring mutations...
In this paper we propose a deep learning approach for segmenting sub-cortical structures of the human brain in Magnetic Resonance (MR) image data. We draw inspiration from state-of-the-art Fully-Convolutional Neural Network (F-CNN) architecture semantic segmentation objects natural images, and adapt it to our task. Unlike previous CNN-based methods that operate on patches, model is applied full blown 2D image, without any alignment or registration steps at testing time. further improve...
Abstract Background Childhood cancer survivorship issues represent an established public health challenge. Most late adverse effects (LAEs) have been demonstrated to be time and treatment dependent. The PETALE study is a multidisciplinary research project aiming comprehensively characterize LAEs identify associated predictive biomarkers in childhood acute lymphoblastic leukemia (cALL) survivors. Methods cALL survivors treated at Sainte‐Justine University Health Center with Dana‐Farber Cancer...
Atypical head circumference (HC) growth has been associated with neurodevelopmental disorders. However, whether it is specific aspects of development in early childhood the general population unknown. The objective this study was to assess predictive value HC as an biomarker behavioral traits. We examined longitudinal associations between from 0 12 months and temperament, cognitive, motor at 24 months. A subsample healthy children (N = 756) drawn 3D (Design, Develop, Discover) cohort study....
Orbital fibroblasts in culture display phenotypic attributes that distinguish them from derived other anatomical regions. The current studies were conducted to define potential cellular heterogeneity among orbital with regard 1) differential expression of Thy-1, a 25-kilodalton glycoprotein associated cell signaling; 2) cells undergoing change shape response prostaglandin E2 (PGE2); and 3) differences morphology Thy-1 between single cell-derived clonal fibroblast strains. On the basis flow...
Although several clinical trials have evaluated the impact of n-3 polyunsaturated fatty acid (PUFA) on patients with attention-deficit hyperactivity disorder (ADHD), changes in plasma PUFA composition were not always assessed following supplementation. Furthermore, no reports are available efficacy Canadian youth ADHD.To determine (FA) composition, and safety supplementation ADHD symptoms French primary school children.The Strengths Weaknesses Normal Behaviors (SWAN) Conners' questionnaires...
Fragile X Syndrome (FXS) is the most common monogenic form of intellectual disability and one few known causes autism. It caused by a trinucleotide repeat expansion in FMR1 ('Fragile Mental Retardation 1') gene, which prevents expression 'Fragile Protein' (FMRP). In FXS, absence FMRP leads to altered structural functional development synapse, while preventing activity-based synapse maturation synaptic pruning, are essential for normal brain cognitive development. Possible impairments...
Most childhood acute lymphoblastic leukemia (ALL) survivors develop chronic treatment-related adverse effects several years after the end of therapy. A regular practice physical activity and a good cardiorespiratory fitness have potential to reduce risk disease improve quality life. The aim this study was evaluate in cohort ALL survivors, association between or respect guidelines major long-term health outcomes.In total, 247 underwent cardiopulmonary exercise test, completed questionnaire...
Abstract Quantifying cognitive potential relies on psychometric measures that do not directly reflect cortical activity. While the relationship between ability and resting state EEG signal dynamics has been extensively studied in children with below-average performances, there remains a paucity of research focusing individuals normal to above-average functioning. This study aimed elucidate aged four 12 years across potential. Our findings indicate complexity, as measured by Multiscale...
Background/Objectives: Previous research suggests that sleep quality and duration may significantly impact sensory experiences, yet the specific relationships in healthy early childhood remain unclear. This study explores relationship between parameters processing outcomes typically developing children followed longitudinally from 3 to 12 months 4 years of age. Methods: We assessed problems, duration, onset latency, parasomnias, a sample (N = 85). Sleep were reported by parents, was...
<title>Abstract</title> Snijders Blok-Campeau syndrome (SNIBCPS), a neurodevelopmental disorder first described in 2018, is caused by heterozygous pathogenic variants CHD3. Its encoded protein plays crucial role the development of nervous system embryos. While phenotypic traits have been broadly defined (i.e. global delays such as intellectual disabilities and delayed speech acquisition, physical features characteristic facial macrocephaly), spectrum has not further assessed. We present...
<title>Abstract</title> <bold>Background. </bold>Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders defined by stereotyped behavior and challenges in social communication interaction. ASD associated with various comorbidities, including anxiety, gastrointestinal (GI) symptoms sleep disorders. Evidence supports an association between intestinal dysbiosis the severity ASD-related symptoms. Probiotic intake was suggested to restore microbial homeostasis decrease...
Copy number variants (CNVs) are well-known genetic pleiotropic risk factors for multiple neurodevelopmental and psychiatric disorders (NPDs), including autism (ASD) schizophrenia. Little is known about how different CNVs conferring the same condition may affect subcortical brain structures these alterations relate to level of disease conferred by CNVs. To fill this gap, authors investigated gross volume, vertex-level thickness, surface maps in 11 six NPDs.
Abstract Background Systematic assessment of emotional distress is recommended in after care. Yet, it unclear if parent report may be used as a proxy child report. The aim this study was to assess agreements and differences explore possible moderators disagreement between ratings. Methods Sixty‐two young survivors treated for acute lymphoblastic leukemia (9–18 years) both parents responded the Beck Youth Inventory (anxiety depression) rating scale on child's status. Parents completed Brief...