A5033412343- Obsessive-Compulsive Spectrum Disorders
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Body Image and Dysmorphia Studies
- Functional Brain Connectivity Studies
- Neural and Behavioral Psychology Studies
- Psychology of Moral and Emotional Judgment
- Autism Spectrum Disorder Research
- Electroconvulsive Therapy Studies
- Eating Disorders and Behaviors
- COVID-19 and Mental Health
- Behavioral and Psychological Studies
- Mental Health Research Topics
- Advanced Neuroimaging Techniques and Applications
- Health, Environment, Cognitive Aging
- Dementia and Cognitive Impairment Research
- EEG and Brain-Computer Interfaces
- Digital Mental Health Interventions
- Cognitive Abilities and Testing
- Takotsubo Cardiomyopathy and Associated Phenomena
- Technology Use by Older Adults
- Gambling Behavior and Treatments
- Cardiac Structural Anomalies and Repair
- Transcranial Magnetic Stimulation Studies
- Sexuality, Behavior, and Technology
- Hemispheric Asymmetry in Neuroscience
University of Cambridge
2019-2025
University of Tübingen
2024-2025
German Center for Diabetes Research
2025
Neuroscience Institute
2023-2024
Sunway University
2022-2024
Monash University Malaysia
2023
University of Malaya
1988-2021
International Medical University
2021
There has been little analysis of neurochemical correlates compulsive behaviour to illuminate its underlying neural mechanisms. We use 7-Tesla proton magnetic resonance spectroscopy (1H-MRS) assess the balance excitatory and inhibitory neurotransmission by measuring glutamate GABA levels in anterior cingulate cortex (ACC) supplementary motor area (SMA) healthy volunteers participants with Obsessive-Compulsive Disorder (OCD). Within SMA, trait clinical measures are related levels, whereas a...
Abstract Background Obsessive-compulsive symptoms (OCS) emerge in a significant proportion of clozapine-treated schizophrenia patients, affecting social functioning and increasing depressive symptoms. This study investigates the underexplored cognitive mechanisms clozapine-induced OCS, particularly focusing on dysfunctional checking behavior. Methods Clinical profiles OCS their relationship to were investigated using novel paradigm (image verification task or IVT) four groups: patients with...
<h3>Importance</h3> Adults with obsessive-compulsive disorder (OCD) display perseverative behavior in stable environments but exhibit vacillating choice when payoffs are uncertain. These findings may be associated intolerance of uncertainty and compulsive behaviors; however, little is known about the mechanisms underlying learning decision-making youths OCD because research into this population has been limited. <h3>Objective</h3> To investigate cognitive by using executive functioning tasks...
Computational research had determined that adults with obsessive-compulsive disorder (OCD) display heightened action updating in response to noise the environment and neglect metacognitive information (such as confidence) when making decisions. These features are proposed underlie patients' compulsions despite knowledge they irrational. Nonetheless, it is unclear whether this extends adolescents OCD population lacking. Thus, study aimed investigate interplay between confidence...
Compulsive checking, a common symptom of obsessive-compulsive disorder (OCD), has been difficult to capture experimentally. Therefore, determination its neural basis remains challenging despite some evidence suggesting that it is linked dysfunction cingulostriatal systems. This study introduces novel experimental paradigm measure excessive checking and neurochemical correlates.
This study investigates the goal/habit imbalance theory of compulsion in obsessive-compulsive disorder (OCD), which postulates enhanced habit formation, increased automaticity, and impaired arbitration. It directly tests these hypotheses using newly developed behavioral tasks. First, OCD patients healthy participants were trained daily for a month smartphone app to perform chunked action sequences. Despite similar procedural learning attainment habitual performance (measured by an objective...
Compulsive behaviour may often be triggered by Pavlovian cues. Assessing how cues drive instrumental in obsessive-compulsive disorder (OCD) is therefore crucial to understand compulsions develop and are maintained. An aversive Pavlovian-to-Instrumental transfer (PIT) paradigm, particularly one involving avoidance/cancellation of negative outcomes, can enable such investigation has not previously been studied clinical-OCD. Forty-one participants diagnosed with OCD (21 adults; 20 youths) 44...
BackgroundCompulsive behaviour is often triggered by Pavlovian cues. Assessing how cues drive instrumental in obsessive-compulsive disorder (OCD) therefore crucial to understand compulsions develop and are maintained. An aversive Pavlovian-to-Instrumental transfer (PIT) paradigm, particularly one involving avoidance/cancellation of negative outcomes, can enable such investigation has not previously been studied clinical-OCD. MethodsForty-one participants diagnosed with OCD (21 adults; 20...
A significant challenge for psychiatry is to explain precisely how the brain generates psychopathology, as its translation presumed advance effective mechanism-based treatments.Computational psychiatrya mathematical understanding of mental illnesshas emerged bridge this explanatory gap [1].Broadly, computational uses models study psychiatric disorders, typically done via 1) an quantitative modelling approach aberrant computations mind produce symptoms, and 2) data-driven modelling, commonly...
Enhanced habit formation, greater automaticity and impaired goal/habit arbitration in obsessive-com-pulsive disorder (OCD) are key hypotheses from the imbalance theory of compulsion which have not been directly investigated. This study tests these using a combination newly developed behavioral tasks. First, we trained both OCD patients healthy controls, smartphone app, to perform chunked action sequences. motor training was conducted daily for one month. Both groups displayed equivalent...
<title>Abstract</title> Aging is associated with declines in cognition and brain structural integrity. However, there equivocality over 1) the specificity of affected domains different people, 2) location patterns deterioration, 3) sociodemographic factors contributing to ‘unhealthy’ cognition. We aimed identify cognitive profiles displayed by older adults determine features potentially shaping these profiles. A sample Southeast-Asian (N = 386) participated a multi-session study comprising...
This study investigates the goal/habit imbalance theory of compulsion in obsessive-compulsive disorder (OCD), which postulates enhanced habit formation, increased automaticity, and impaired arbitration. It directly tests these hypotheses using newly developed behavioral tasks. First, OCD patients healthy participants were trained daily for a month smartphone app to perform chunked action sequences. Despite similar procedural learning attainment habitual performance (measured by an objective...
The human reward system has been extensively studied using neuroimaging. This bibliometric analysis aimed to determine the global trend in diffusion magnetic resonance imaging (dMRI) and research terms of number documents, most active countries their collaborating countries, top journals institutions, prominent authors cited articles, hotspots.
Aging is associated with declines in cognition and brain structural integrity. However, there equivocality over (1) the specificity of affected domains different people, (2) location patterns deterioration, (3) sociodemographic factors contributing to 'unhealthy' cognition. We aimed identify cognitive profiles displayed by older adults determine features potentially shaping these profiles. A sample Southeast-Asian (N = 386) participated a multi-session study comprising testing, neuroimaging,...
Enhanced habit formation, greater automaticity and impaired goal/habit arbitration in obsessive-compulsive disorder (OCD) are key hypotheses from the imbalance theory of compulsion which have not been directly investigated. This article tests these using a combination newly developed behavioral tasks. First, we trained patients with OCD healthy controls, novel smartphone app, to perform chunked action sequences, previously shown engage brain circuitry. The motor training was daily over one...
Enhanced habit formation, greater automaticity and impaired goal/habit arbitration in obsessive-compulsive disorder (OCD) are key hypotheses from the imbalance theory of compulsion which have not been directly investigated. This study tests these using a combination newly developed behavioral tasks. First, we trained both OCD patients healthy controls, smartphone app, to perform chunked action sequences. motor training was conducted daily for one month. Both groups displayed equivalent...
Abstract A case of peripartum cardiomyopathy occurring in a Malay patient is presented. Diagnosis this condition can be difficult and usually one exclusion. The clinical course the disease presented highlighting points favour rather poorly appreciated misdiagnosed condition. To our knowledge first report patient.