A5082318076- Obsessive-Compulsive Spectrum Disorders
- Neurobiology of Language and Bilingualism
- Eating Disorders and Behaviors
- Language Development and Disorders
- Phonetics and Phonology Research
- Reading and Literacy Development
- Stuttering Research and Treatment
- Electroconvulsive Therapy Studies
- Body Image and Dysmorphia Studies
- Treatment of Major Depression
- Advanced Neuroimaging Techniques and Applications
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neural and Behavioral Psychology Studies
- Behavioral Health and Interventions
- Neonatal and fetal brain pathology
- Cognitive Abilities and Testing
- Fetal and Pediatric Neurological Disorders
- Congenital heart defects research
University of Cambridge
2020-2024
Wellcome Centre for Integrative Neuroimaging
2020-2024
University of Oxford
2020-2024
Wellcome Trust
2020-2023
Google (United States)
2021
There has been little analysis of neurochemical correlates compulsive behaviour to illuminate its underlying neural mechanisms. We use 7-Tesla proton magnetic resonance spectroscopy (1H-MRS) assess the balance excitatory and inhibitory neurotransmission by measuring glutamate GABA levels in anterior cingulate cortex (ACC) supplementary motor area (SMA) healthy volunteers participants with Obsessive-Compulsive Disorder (OCD). Within SMA, trait clinical measures are related levels, whereas a...
Developmental language disorder (DLD) is a common neurodevelopmental characterised by receptive or expressive difficulties both. While theoretical frameworks and empirical studies support the idea that there may be neural correlates of DLD in frontostriatal loops, findings are inconsistent across studies. Here, we use novel semiquantitative imaging protocol - multi-parameter mapping (MPM) to investigate microstructural differences children with DLD. The MPM allows us reproducibly map...
Developmental language disorder (DLD) is characterised by difficulties in learning one's native for no apparent reason. These occur 7% of children and are known to limit future academic social achievement. Our understanding the brain abnormalities associated with DLD limited. Here, we used a simple four-minute verb generation task (children saw picture an object were instructed say action that goes object) test between ages 10–15 years (DLD N = 50, typically developing 67). We also tested 26...
Purpose People who stutter (PWS) have more unstable speech motor systems than people are typically fluent (PWTF). Here, we used real-time magnetic resonance imaging (MRI) of the vocal tract to assess variability and duration movements different articulators in PWS PWTF during production. Method The tracts 28 adults with moderate severe stuttering 20 were scanned using MRI while repeating simple complex pseudowords. Midsagittal images from lips larynx reconstructed at 33.3 frames per second....
Compulsive checking, a common symptom of obsessive-compulsive disorder (OCD), has been difficult to capture experimentally. Therefore, determination its neural basis remains challenging despite some evidence suggesting that it is linked dysfunction cingulostriatal systems. This study introduces novel experimental paradigm measure excessive checking and neurochemical correlates.
Children with developmental language disorder (DLD) struggle to learn their native for no apparent reason. While research on the neurobiological underpinnings of has focused role corticostriatal systems, little is known about cerebellum in DLD. Corticocerebellar circuits might be involved as they contribute complex sensorimotor skill learning, including acquisition spoken language. Here, we used diffusion-weighted imaging data from 77 typically developing and 54 children DLD performed...
Abstract Approximately 7% of children have developmental language disorder (DLD), a neurodevelopmental condition associated with persistent learning difficulties without known cause. Our understanding the neurobiological basis DLD is limited. Here, we used FreeSurfer to investigate cortical surface area and thickness in large cohort 156 adolescents aged 10–16 years range abilities, including 54 DLD, 28 history speech-language who did not meet criteria for 74 age-matched controls typical...
Children with developmental language disorder (DLD) struggle to learn their native for no apparent reason. While research on the neurobiological underpinnings of has focused role cortico-striatal systems, little is known about cerebellum in DLD. Cortico-cerebellar circuits might be involved as they contribute complex sensorimotor skill learning, including acquisition spoken language. Here, we used diffusion-weighted imaging data from 77 typically developing and 54 children DLD performed...
Background Several studies indicate that people who stutter show greater variability in speech movements than do not stutter, even when the produced is perceptibly fluent. Speaking to beat of a metronome reliably increases fluency regardless severity stuttering. Objectives Here, we aimed test whether metronome-timed reduces articulatory variability. Method We analysed vocal tract MRI data from 24 and 16 controls. Participants repeated sentences with without metronome. Midsagittal images lips...
AbstractBackground: Several studies indicate that people who stutter show greater variability in speech movements than do not stutter, even when the produced is perceptually fluent. Speaking to beat of a metronome reliably increases fluency regardless severity stuttering. Objectives: Here, we aimed test whether metronome-timed reduces articulatory variability. Method: We analysed vocal tract MRI data from 24 and 16 controls. Participants repeated sentences with without metronome. Midsagittal...
ABSTRACT Approximately seven per cent of children have developmental language disorder (DLD), a neurodevelopmental condition associated with persistent learning difficulties without known cause. Our understanding the neurobiological basis DLD is limited. Here, we used FreeSurfer to investigate cortical surface area and thickness in 54 adolescents 74 age-matched controls aged 10-16 years. We also examined asymmetries using an automated surface-based technique. Those showed smaller bilaterally...
Abstract Developmental stuttering is a speech motor disorder characterised by difficulties initiating and frequent interruptions to the flow. Previous work suggests that people who stutter (PWS) have an overactive response suppression mechanism. Imaging studies of production in PWS consistently reveal greater activity right inferior frontal cortex, area robustly implicated inhibitory control both manual spoken responses. Here, we used version stop-signal task during fMRI investigate neural...