A5038069814- Functional Brain Connectivity Studies
- Hemispheric Asymmetry in Neuroscience
- Congenital heart defects research
- Morphological variations and asymmetry
- Genomics and Rare Diseases
- Genomic variations and chromosomal abnormalities
- Dementia and Cognitive Impairment Research
- Advanced Neuroimaging Techniques and Applications
- Vestibular and auditory disorders
- Musculoskeletal pain and rehabilitation
- Pain Management and Placebo Effect
- Alzheimer's disease research and treatments
- Neural and Behavioral Psychology Studies
- Neurological disorders and treatments
- Health Systems, Economic Evaluations, Quality of Life
- Cognitive Abilities and Testing
- Neural dynamics and brain function
- Gene expression and cancer classification
- Memory and Neural Mechanisms
- Pain Mechanisms and Treatments
- EEG and Brain-Computer Interfaces
- Neuroscience and Neural Engineering
- Reading and Literacy Development
- Medical and Biological Sciences
- Neuroscience and Music Perception
Montreal Neurological Institute and Hospital
2022-2024
McGill University
2022-2024
Mila - Quebec Artificial Intelligence Institute
2023-2024
National University of Singapore
2024
Weatherford College
2024
University of Oxford
2024
Abstract The human cerebellum is increasingly recognized to be involved in non-motor and higher-order cognitive functions. Yet, its ties with the entire cerebral cortex have not been holistically studied a whole-brain exploration unified analytical framework. Here, we characterized disso-ciable cortical-cerebellar structural covariation patterns across brain n=38,527 UK Bio-bank participants. Our results invigorate previous observations that important shares of corti-cal-cerebellar are...
Abstract Asymmetry between the left and right hemisphere is a key feature of brain organization. Hemispheric functional specialization underlies some most advanced human-defining cognitive operations, such as articulated language, perspective taking, or rapid detection facial cues. Yet, genetic investigations into asymmetry have mostly relied on common variants, which typically exert small effects brain-related phenotypes. Here, we leverage rare genomic deletions duplications to study how...
Abstract The amygdala nuclei modulate distributed neural circuits that most likely evolved to respond environmental threats and opportunities. So far, the specific role of unique in context processing salient cues lacks adequate characterization across systems over time. Here, we present morphometry behavioral findings from longitudinal population data (>1400 subjects, age range 40-69 years, sampled 2-3 years apart): UK Biobank offers exceptionally rich phenotyping along with brain...
Cerebellum’s association with the entire cerebral cortex has not been holistically studied in a unified way. Here, we conjointly characterize population-level cortical-cerebellar structural covariation patterns leveraging ∼40,000 UK Biobank participants whole brain scans and ∼1,000 phenotypes. We revitalize previous hypothesis of an anticorrelation between visual-attention system advanced associative networks within cerebellum. also discovered novel ipsilateral cerebral-cerebellar...
Abstract Asymmetry between the left and right brain is a key feature of organization. Hemispheric functional specialization underlies some most advanced human-defining cognitive operations, such as articulated language, perspective taking, or rapid detection facial cues. Yet, genetic investigations into asymmetry have mostly relied on common variant studies, which typically exert small effects phenotypes. Here, we leverage rare genomic deletions duplications to study how alterations...
Abstract Alzheimer’s disease and related dementias (ADRD) are marked by intracellular tau aggregates in the medial-temporal lobe (MTL) extracellular amyloid default network (DN). Here, we sought to clarify ADRD-related co-dependencies between MTL’s most vulnerable structure, hippocampus (HC), highly associative DN at a subregion resolution. We confronted effects of APOE ɛ2 ɛ4, rarely investigated together, with their impact on HC-DN co-variation regimes population level. In two-pronged...
Abstract Copy number variations (CNVs) are rare genomic deletions and duplications that can exert profound effects on brain behavior. Previous reports of pleiotropy in CNVs imply they converge shared mechanisms at some level pathway cascades, from genes to large-scale neural circuits the phenome. However, studies date have primarily examined single CNV loci small clinical cohorts. It remains unknown how distinct escalate risk for same developmental psychiatric disorders. Here, we...
Alzheimer's disease is marked by intracellular tau aggregates in the medial temporal lobe (MTL) and extracellular amyloid default network (DN). Here, we examined codependent structural variations between MTL's most vulnerable structure, hippocampus (HC), DN at subregion resolution individuals with related dementia (ADRD). By leveraging power of approximately 40,000 participants UK Biobank cohort, assessed impacts from protective APOE ɛ2 deleterious ɛ4 alleles on these relationships. We...
Abstract The rapid shifts of society have brought about changes in human behavioral patterns, with increased evening activities, screen time, and postponed sleep schedules. As an explicit manifestation circadian rhythms, chronotype is closely intertwined both physical mental health. Night owls often exhibit more unhealthy lifestyle habits, are susceptible to mood disorders, poorer fitness. Although individual differences yield varying consequences, their neurobiological underpinnings remain...
<title>Abstract</title> Human beings may have evolved the largest asymmetries of brain organization in animal kingdom. Hemispheric left-vs-right specialization is especially pronounced our species-unique capacities. Yet, asymmetry features appear to be strongly shaped by non-genetic influences. We hence charted longitudinal brain-imaging adult resource, yielding evidence that changes continuously a manner suggestive neural plasticity. In UK Biobank population cohort, we demonstrate show...
Abstract Background Pain is a complex problem that triaged, diagnosed, treated, and billed based on which body part painful, almost without exception. While the “body framework” guides organization treatment of individual patients’ pain conditions, it remains unclear how to best conceptualize, study, treat conditions at population level. Here, we investigate (1) framework agrees with population-level, biologically derived profiles; (2) do data-derived profiles interface other symptom domains...
Abstract Sleep dysfunction affects over 90% of Parkinson’s disease patients. Recently, subthalamic nucleus deep brain stimulation has shown promise for alleviating sleep dysfunction. We previously showed that a single-layer neural network could classify stages from local field potential recordings in However, it was unable to categorise non-rapid eye movement into its different sub-stages. Here we employ larger hidden layer architecture distinguish the substages with reasonable accuracy, up...
Abstract We consider a shift in pain medicine delivery systems from the conventional, body-part-based approach to one anchored intricate, real-world experience and holistic profiles of patient function. Utilizing largest biomedical dataset date (n = 34,337), we unearth four unique, biologically-based that cut across medical specialties: interference, depression, pain, anxiety, each representing different facets functional impairment. Importantly, these do not specifically align with...