A5049958348- Childhood Cancer Survivors' Quality of Life
- Advanced Causal Inference Techniques
- Acute Lymphoblastic Leukemia research
- Nutrition and Health in Aging
- LGBTQ Health, Identity, and Policy
- Statistical Methods and Bayesian Inference
- Statistical Methods and Inference
- Pregnancy and Medication Impact
- Children's Physical and Motor Development
- Health Systems, Economic Evaluations, Quality of Life
- Taxation and Compliance Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Cognitive Abilities and Testing
- Pregnancy and preeclampsia studies
- Family Support in Illness
- HIV/AIDS Research and Interventions
- Eosinophilic Esophagitis
- Adolescent and Pediatric Healthcare
- Chemotherapy-induced cardiotoxicity and mitigation
- Sexual Assault and Victimization Studies
- Cerebral Palsy and Movement Disorders
- Education, sociology, and vocational training
- African Sexualities and LGBTQ+ Issues
- Qualitative Comparative Analysis Research
- Reproductive System and Pregnancy
Centre Hospitalier Universitaire Sainte-Justine
2017-2024
Université de Montréal
2016-2024
Université du Québec à Montréal
2016-2023
Kharkiv National University of Internal Affairs
2019
Hôpital du Sacré-Cœur de Montréal
2016-2018
Abstract Background Childhood cancer survivorship issues represent an established public health challenge. Most late adverse effects (LAEs) have been demonstrated to be time and treatment dependent. The PETALE study is a multidisciplinary research project aiming comprehensively characterize LAEs identify associated predictive biomarkers in childhood acute lymphoblastic leukemia (cALL) survivors. Methods cALL survivors treated at Sainte‐Justine University Health Center with Dana‐Farber Cancer...
Abstract Our objectives were to assess the prevalence of cardiometabolic complications in children, adolescents, and young adult survivors childhood acute lymphoblastic leukemia (cALL), identify their predictors risk compared Canadian population. We performed a assessment cALL from PETALE cohort (n = 247, median age at visit 21.7 years). In our group, overweight obesity affected over 70% women. Pre-hypertension hypertension mostly common men, both adults (20%) children (19%). Prediabetes was...
Most childhood acute lymphoblastic leukemia (ALL) survivors develop chronic treatment-related adverse effects several years after the end of therapy. A regular practice physical activity and a good cardiorespiratory fitness have potential to reduce risk disease improve quality life. The aim this study was evaluate in cohort ALL survivors, association between or respect guidelines major long-term health outcomes.In total, 247 underwent cardiopulmonary exercise test, completed questionnaire...
Abstract Background Recent research has suggested that long‐term pediatric cancer survivors were at risk of important physical and psychological morbidities. To date, we do not know to what extent functional health status contributes which domains are most important. The aim this study was systematically explore domain could explain anxiety, depression, distress symptoms. Procedure We used data available for 105 adolescents 182 adults successfully treated childhood acute lymphoblastic...
Introduction: As the survival rate of childhood acute lymphoblastic leukemia (ALL) continues to improve, physical deconditioning is becoming an increasingly common problem in survivors. The aim this study was compare cardiorespiratory fitness and activity levels survivors control participants. Methods: A total 221 ALL (114 males 107 females), diagnosed between 1987 2010 treated according Dana Farber Cancer Institute-ALL 87-01 05-01 protocols at Sainte-Justine University Health Center...
Abstract Survivors of childhood acute lymphoblastic leukemia (cALL) are at higher risk developing cardiometabolic complications. We aimed exploring the associations between biomarkers inflammation, oxidative stress, endothelial function, endotoxemia and factors. conducted a cross-sectional analysis in 246 cALL survivors (mean age, 22.1 ± 6.3 years; mean time since diagnosis, 15.5 5.2 years) evaluated using series logistic regressions. Using structural equation models, we also tested if...
Introduction: More than two thirds of survivors have long-term adverse effects, and no study proposes a portrait physical activity level in childhood acute lymphoblastic leukemia survivors. The aims this were to present the cardiorespiratory fitness (CRF) levels detailed overview sedentary activities portrait. Methods: A total 247 included our study. Survivors underwent cardiopulmonary exercise test on ergocycle completed questionnaires assess their leisure daily energy expenditure. Results:...
Abstract In the causal mediation framework, several parametric-regression–based approaches have been introduced in last decade for estimating natural direct and indirect effects. For a binary outcome, number of proposed estimators use logistic model rely on specific assumptions or approximations that may be delicate not easy to verify practice. To circumvent challenges prompted by rare outcome assumption this context, an exact closed-form natural-effects estimator odds ratio scale was...
Background Despite greater acceptance of sexual and gender diversity the scientific consensus that same-gender attraction, creative expression, transness are not mental illnesses, LGBTQI2+ persons still commonly told they can or should change their orientation, identity, expression (SOGIE). The aim this study was to describe prevalence SOGIE conversion efforts, including sociodemographic correlates, among persons. Methods Using community-based sampling, we assessed attempts involvement in...
Abstract Background Cohorts of childhood acute lymphoblastic leukemia (cALL) survivors reaching adulthood are increasing. Approximately 30% meet criteria for low bone mineral density (BMD) 10 years after diagnosis. We investigated risk factors BMD in long‐term cALL survivors. Methods recruited 245 from the PETALE (Prévenir les effets tardifs des traitements de la leucémie aiguë lymphoblastique chez l'enfant) cohort, who were treated with Dana Farber Cancer Institute protocols, did not...
Concealing one's non-heterosexual orientation (NHO) remains a protection strategy against workplace discrimination used by many lesbian, gay, bisexual, and queer (LGBQ+) individuals. This article explores four sets of correlates (identity individual trajectory, social support, professional position, structural cultural work context) relative to three levels outness (total, partial, null). Online cross-sectional data 2,106 LGBQ+ participants from Quebec (Canada) showed that 27% reported total...
Background: In the binary outcome framework to causal mediation, closed-form expressions introduced by Valeri and VanderWeele for natural direct indirect effect odds ratios (ORs) are established from a logistic model invoking several approximations that hold under rare-disease assumption.Such ORs expected be close corresponding effects on risk ratio (RR) scale based log-binomial model, however new insight indicates this is not always verified.The objective was report mediation results these...
Abstract Background The prevalence of vertebral deformities in long-term survivors childhood acute lymphoblastic leukemia (ALL) is unknown. Our objectives were to identify the and their risk factors among ALL survivors. Methods/Results We recruited 245 (49% male) from Preventing Late Adverse Effects Leukemia Cohort (French-Canadian treated between years 1987 2010 with Dana Farber Cancer Institute clinical trials protocols, who did not experience disease relapse and/or receive hematopoietic...
The variable “small for gestational age,” frequently defined as birth weight below the 10th percentile in a age and sex-normalized population, is nowadays generally perceived more adequate measure than or low (birth < 2500 g) to capture fetal growth. However, use of small rather an outcome (dependent) may have important impacts on interpretation analyses aimed at estimating causal effect exposure interest infants. We hypothesized potential differences both types effects estimated (direct...
In the causal mediation framework, a number of parametric regression‐based approaches have been introduced in recent years for estimating natural direct and indirect effects binary outcome an exact manner, without invoking simplifying assumptions based on rareness or commonness outcome. However, most these works focused mediator. this article, we aim at continuous mediator introduce approach estimation odds ratio, risk difference scales. Our relies logistic linear models mediator,...
Asthma is a heterogeneous disease, and responses to asthma medications vary noticeably among patients. A substantively oriented objective of this study was explore the potentially effects exposure maternal inhaled corticosteroids (ICS) on gestational age (GA) at delivery birth weight (BW) using cohort 6,197 pregnancies women with (Quebec, Canada, 1998–2008). methodologically comprehensively describe application Bayesian 2-component mixture-of-bivariate-regressions model address issue...
Childhood acute lymphoblastic leukemia (cALL) is the most frequent pediatric cancer. Over past decades, treatment of cALL has significantly improved, with cure rates close to 90%. However intensive chemotherapy and cranial radiotherapy (CRT) during a critical period child's development have been shown lead significant long-term side effects including cardiometabolic complications. Using PETALE (Prévenir les effets tardifs des traitements de la leucémie aiguë lymphoblastique chez l'enfant)...
Purpose: Inhaled corticosteroids (ICS) are the first-line controller therapy for asthma.The objective was to assess impact of different ICS doses during pregnancy on birth weight (BW) using generalized propensity scores (GPS).Methods: A cohort 7374 pregnancies from 6197 asthmatic women giving in Quebec (Canada) 1998-2008 constructed.The average treatment effects (ATE) daily (0, >0-125, >125-250, >250 µg/day) BW were estimated multilevel GPS and a conventional multivariable...
Mediation analysis with a binary outcome is notoriously more challenging than continuous outcome. A new Bayesian approach for performing causal mediation and mediator, named the t-link approach, introduced. This relies on multivariate logistic regression model introduced by O'Brien Dunson (2004) its Student-t approximation. By re-expressing Formula, it shown how to use this latent estimating natural direct indirect effects of an exposure in any measure scale interest (e.g., odds or risk...
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