A5014358655- CRISPR and Genetic Engineering
- Animal Genetics and Reproduction
- Genetically Modified Organisms Research
- Telomeres, Telomerase, and Senescence
- Cardiac Arrhythmias and Treatments
- DNA Repair Mechanisms
- Autophagy in Disease and Therapy
- Cardiac pacing and defibrillation studies
- Transplantation: Methods and Outcomes
- Atrial Fibrillation Management and Outcomes
- Cancer-related molecular mechanisms research
- Nutrition and Health in Aging
- Childhood Cancer Survivors' Quality of Life
- RNA modifications and cancer
- Systemic Sclerosis and Related Diseases
- Congenital Heart Disease Studies
- Parkinson's Disease Mechanisms and Treatments
- Protein Hydrolysis and Bioactive Peptides
- Hematopoietic Stem Cell Transplantation
- Head and Neck Cancer Studies
- Cancer-related gene regulation
- Cancer-related Molecular Pathways
- Immunotherapy and Immune Responses
- Heavy Metal Exposure and Toxicity
- Cardiovascular Syncope and Autonomic Disorders
Université de Montréal
2020-2025
Centre Hospitalier de l’Université de Montréal
2012-2024
VetAgro Sup
2023
Université Clermont Auvergne
2023
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2023
Institute for Research in Immunology and Cancer
2018
Hôpitaux Universitaires de Strasbourg
2012
McGill University Health Centre
2012
Université du Québec à Montréal
2009
University of Padua
1976-1992
Sustained macroautophagy/autophagy favors the differentiation of fibroblasts into myofibroblasts. Cellular senescence, another means responding to long-term cellular stress, has also been linked myofibroblast and fibrosis. Here, we evaluate relationship between senescence in context sustained autophagy. We analyzed markers cell cycle arrest/senescence vitro, where autophagy was triggered by serum starvation (SS). Autophagic expressed biomarkers CDKN1A/p21 CDKN2A/p16 exhibited increased...
Radiotherapy (RT) is a key component of cancer treatment. Most the time, radiation given after surgery but for soft-tissue sarcomas (STS), pre-surgical commonly utilized. However, despite improvements in RT accuracy, rate local recurrence remains high and major cause death patients with STS. A better understanding cell fates response to could provide new therapeutic options enhance tumour killing by facilitate surgical resection. Here, we showed that irradiated STS cultures do not die...
Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer. Contributory factors such as inflammation and oxidative stress, in response to drug therapies, may induce premature aging cellular senescence with a severe impact on cardiometabolic health. Premature immunoaging through can lead lower thymic output of T-cell lymphocytes translated into circulating receptor excision circles (TRECs). We hypothesized TRECs levels are associated diet quality impacted by inflammatory status...
Childhood acute lymphoblastic leukemia (cALL) survivors suffer early-onset chronic diseases classically associated with aging. Normal aging is accompanied by organ dysfunctions, including immunological ones. We hypothesize that thymic immunosenescence occurs in cALL and its severity may correlate diseases. The PETALE study a survivor cohort an extensive cardiovascular metabolic evaluation. biomarker, signal joint T-cell receptor excision circles (TREC), was evaluated highly correlated age...
Abstract Survivors of childhood acute lymphoblastic leukemia (cALL) are at higher risk developing cardiometabolic complications. We aimed exploring the associations between biomarkers inflammation, oxidative stress, endothelial function, endotoxemia and factors. conducted a cross-sectional analysis in 246 cALL survivors (mean age, 22.1 ± 6.3 years; mean time since diagnosis, 15.5 5.2 years) evaluated using series logistic regressions. Using structural equation models, we also tested if...
The purpose of this study was to determine the prognostic value and oncogenic pathways associated miRNA expression in squamous cell carcinoma oral tongue link these candidates with potential gene targets. We performed a screening within our institutional cohort (n = 58 patients) reported five targets including cluster four co-expressed miRNAs (miR-18a, miR-92a, miR-103, miR-205). Multivariate analysis showed that miR-548b (p 0.007) miR-18a 0.004, representative miRNAs) are independent...
Genomic analyses of head and neck squamous cell carcinoma (HNSCC) have highlighted alterations in the phosphatidylinositol 3-kinase (PI3K) signaling pathway, presenting a therapeutic target for multiple ongoing clinical trials with PI3K or PI3K/MTOR inhibitors. However, these inhibitors can potentially increase autophagy HNSCC indirectly support cancer survival. Here, we sought to understand relationship between pathway during their dual inhibition panel lines. We used acridine orange...
Rapid T cell reconstitution following hematopoietic stem transplantation (HSCT) is essential for protection against infections and has been associated with lower incidence of chronic graft-versus-host disease (cGVHD), relapse, transplant-related mortality (TRM). While cord blood (CB) transplants are rates cGVHD their low content results in slower immune higher risk graft failure, severe infections, TRM. Recently, a phase I/II trial revealed that single UM171-expanded CB transplant allowed...
Genetic factors behind the increasing incidence of human papillomavirus (HPV) negative head and neck squamous cell carcinoma (HNSCC) in young non-smokers are suspected, but have not been identified. Recently, rs6942067, a single nucleotide polymorphism (SNP) located upstream DCBLD1 gene, was found associated with non-smoking lung adenocarcinoma. To validate if this SNP is also implicated HNSCC, participants The Cancer Genome Atlas HNSCC cohort were investigated for rs6942067 status,...
Abstract Loss of telomeric DNA leads to telomere uncapping, which triggers a persistent, p53-centric damage response that sustains stable senescence-associated proliferation arrest. Here, we show in normal cells uncapping focal accompanied by transient cell cycle Subsequent division with dysfunctional telomeres resulted sporadic sister chromatid fusions gave rise next-mitosis genome instability, including non-telomeric lesions responsible for stable, p53-mediated, Unexpectedly, the blocking...
Abstract Germline single nucleotide polymorphisms in the promoter region of DCBLD1 gene are associated with non-smoking cases both non-small cell lung carcinoma (NSCLC) and human papillomavirus-negative head neck cancer. However clinical relevance function remain unclear. This multicenter retrospective study was designed to evaluate prognostic value four main solid cancers: NSCLC, invasive breast carcinoma, colorectal adenocarcinoma prostate adenocarcinoma. We included following cohorts:...
ABSTRACT Replicative senescence is the permanent growth arrest caused by gradual telomere attrition occurring at each round of genome replication. Critically shortened telomeres lose their protective shelterin complex and t-loop structure revealing uncapped chromosome ends that are recognized as DNA double-strand breaks causing a p53-dependent damage response (DDR) towards proliferation arrest. Because heterogeneous in length within single cell, number short necessary for onset remains ill...
Malignant Melanoma that resists immunotherapy remains the deadliest form of skin cancer owing to poor clinically lasting responses. Alternative like genotoxic or targeted chemotherapy trigger various cell fates after treatment including death and senescence. Senescent cells can be eliminated using senolytic drugs we hypothesize elimination therapy-induced senescent melanoma could complement both conventional immunotherapies. We utilized a panel representing diverse mutational background...
To measure and visualize aerosol generation during ear, nose, throat (ENT) exam flexible laryngoscopy, as safety recommendations are currently to defer routine low-priority examinations.
We hypothesized that the transcriptome of primary cultures morphologically normal ovarian surface epithelial cells could be altered by presence a heterozygous BRCA1 or BRCA2 mutation. aimed to discover early events associated with carcinogenesis, which represent putative targets for preventive strategies this silent killer tumor. identified first molecular signature French Canadian founder mutations in cells. discovered wild-type and mutated allelic transcripts were expressed not only but...
// Vanessa Samouëlian 1, 2, 3 , Nawel Mechtouf 1 Eric Leblanc 4 Guillaume B. Cardin Valérie Lhotellier 5 Denis Querleu 6 Françoise Révillion 5, * and Francis Rodier 7, CRCHUM et Institut du cancer de Montréal, Montreal, QC, Canada 2 Université Département d’Obstétrique Gynécologie, CHUM, Service Gynécologie oncologique, Department of Surgery - Centre Oscar Lambret, Lille Cedex, France Laboratory Human Molecular...