A5080425175- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Infectious Diseases and Mycology
- Pneumocystis jirovecii pneumonia detection and treatment
- Cardiac Arrest and Resuscitation
- Mycobacterium research and diagnosis
- Neutropenia and Cancer Infections
- Organ and Tissue Transplantation Research
- Hematopoietic Stem Cell Transplantation
- Plant Pathogens and Fungal Diseases
- Immune Response and Inflammation
- Tuberculosis Research and Epidemiology
- Ocular Infections and Treatments
- Clostridium difficile and Clostridium perfringens research
- HIV/AIDS drug development and treatment
- COVID-19 and healthcare impacts
- COVID-19 Clinical Research Studies
- Trauma Management and Diagnosis
- Probiotics and Fermented Foods
- Social Robot Interaction and HRI
- Fungal and yeast genetics research
- NF-κB Signaling Pathways
- Medical and Biological Ozone Research
- Bacterial Identification and Susceptibility Testing
- Rabies epidemiology and control
Université de Montréal
2007-2024
Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal
2019-2024
Hôpital Maisonneuve-Rosemont
2013-2024
Centre intégré universitaire de santé et de services sociaux de l'Est-de-l'Île-de-Montréal
2019-2024
Baystate Medical Center
2024
Centre Hospitalier Universitaire Sainte-Justine
2021-2022
Centre Hospitalier de l’Université de Montréal
2019-2022
McGill University Health Centre
2022
Université Laval
2021-2022
Hôpital de l'Enfant-Jésus
2021-2022
Candida auris is an emerging multidrug-resistant yeast that has been systematically incorrectly identified by phenotypic methods in clinical microbiology laboratories. The Vitek 2 automated identification system (bioMérieux) recently included C. its database (version 8.01). We evaluated the performance of YST ID card to identify and related species. A panel 44 isolates species (C. auris, n = 35; haemulonii, 5; duobushaemulonii, 4) were tested three different hospital-based Among 35 yielded...
ABSTRACT Candida kefyr is an emerging pathogen among patients with hematologic malignancies (HM). We performed a retrospective study at Johns Hopkins Hospital to evaluate the epidemiology of C. colonization and infection in HM between 2004 2010. Eighty-three were colonized and/or infected , 8 (9.6%) having invasive candidiasis (IC). The yearly incidence candidemia increased over period ( P < 0.01), particularly after 2009. In 2010, caused 16.7% episodes. monthly was higher during summer...
Mortality associated with invasive aspergillosis (IA) remains high, partly because of delayed diagnosis. Detection microbial exoantigens, released in serum and other body fluids during infection, may help timely In course IA, Aspergillus galactomannan (GM), a well established polysaccharide biomarker, is including urine. Urine an abundant, safely collected specimen, well-suited for point-of-care (POC) testing, which could play increasing role screening early disease. Our main objective was...
Pneumocystis pneumonia (PCP) is associated with morbidity and mortality in solid organ transplant (SOT) recipients. In this case-control study, we determined the association between posttransplant PCP 3 variables: cytomegalovirus (CMV) infection, allograft rejection, prophylaxis. Eight centers participated. For each case (SOT recipient PCP), 3–5 controls recipients without PCP) were included. Controls matched to cases based on center, type of allograft, date transplantation (±6 months). We...
We sought to describe the epidemiology of Clostridium difficile infection (CDI) among adult recipients autologous hematopoietic stem cell transplantation (auto-HSCT) within first year after HSCT in centers with variable hypertoxigenic strains. A multicenter, retrospective nested case-control study was conducted 873 auto-HSCT at Johns Hopkins Hospital (JHH) and Hôpital Maisonneuve-Rosemont (HMR) between January 2003 December 2008. Despite center differences prevalence NAP-1 strains during...
Clostridium difficile infection (CDI) is a significant complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). Our primary objective was to determine risk factors for the development CDI during first year following allo-HSCT.A matched case-control study nested in cohort allo-HSCT at single hospital Montréal, Québec, Canada, conducted from 2002 through 2011.Sixty-five 760 patients who underwent between and 2011 developed CDI, representing an incidence 8.6%. We selected...
Epstein–Barr virus-related post-transplantation lymphoproliferative disorder (EBV-PTLD) is a serious complication following hematopoietic stem cell transplantation (HSCT). A pre-emptive strategy using rituximab, which aims to manage patients early at the time of EBV reactivation avoid PTLD, has been recommended by most recent ECIL-6 guidelines in 2016. However, there still great heterogeneity viral-load monitoring protocols, targeted patient populations, and treatment characteristics between...
Rapid T cell reconstitution following hematopoietic stem transplantation (HSCT) is essential for protection against infections and has been associated with lower incidence of chronic graft-versus-host disease (cGVHD), relapse, transplant-related mortality (TRM). While cord blood (CB) transplants are rates cGVHD their low content results in slower immune higher risk graft failure, severe infections, TRM. Recently, a phase I/II trial revealed that single UM171-expanded CB transplant allowed...
<h3>Background:</h3> The COVID-19 pandemic has disproportionately affected health care workers. We sought to estimate SARS-CoV-2 seroprevalence among hospital workers in Quebec, Canada, after the first wave of and explore factors associated with seropositivity. <h3>Methods:</h3> Between July 6 Sept. 24, 2020, we enrolled from 10 hospitals, including 8 a region high incidence (the Montréal area) 2 low-incidence regions Quebec. Eligible were physicians, nurses, orderlies cleaning staff working...
Azole resistance among Aspergillus fumigatus isolates is a growing concern worldwide. Induction of mutations during azole therapy, environment-acquired caused by fungicides and intrinsic cryptic Fumigati species all contribute to the burden resistance. However, there lack data in Canada on this emerging threat.To gain insights into magnitude mechanisms resistance, 14 year collection section comprising 999 from 807 patients at Montreal hospital was screened for were investigated with combined...
Anncaliia algerae myositis is a life-threatening, emerging microsporidiosis among immunocompromised hosts. We report case of disseminated A infection in man previously treated with alemtuzumab. Due to failure albendazole-based therapy, fumagillin was added as novel approach management, good clinical response and patient survival.
Summary: Facial vascularized composite allotransplantation has emerged as a groundbreaking reconstructive solution for patients with severely disfiguring facial injuries. The authors report on the first Canadian face transplant. A 64-year-old man sustained gunshot wound, which resulted in extensive midface bony and soft-tissue damage involving lower two-thirds of face. In May 2018, he underwent transplant consisting Le Fort III bilateral sagittal split osteotomies addition to skin from neck....
Aerococcus urinae is a urinary pathogen with well-described resistance to fluoroquinolones. This study aimed validate the gradient diffusion (GD) method (Etest) on cation-adjusted Mueller-Hinton agar 5% sheep blood for testing susceptibilities of antimicrobial agents ciprofloxacin and levofloxacin compare Etest broth microdilution (BMD) from CLSI document M45-A3.
Nonsporulating moulds (NSM) represent an identification challenge for clinical laboratories. Data on the prevalence of pathogenic species among NSM are lacking. We prospectively investigated consecutive thermotolerant (36°C) isolates from respiratory tract samples. A total 123 were identified by DNA sequencing and phenotypically characterized. Of those, 13 (11%) (Aspergillus fumigatus, n = 10; A. flavus, 1; hiratsukae, Schizophyllum commune, 1). Presumptive Aspergillus can be achieved simple...
Here, we present the draft genome sequence of Aspergillus thermomutatus (formerly known as Neosartorya pseudofischeri; strain HMR-AF-39/LSPQ-01276), a cryptic species section Fumigati. This is intrinsically resistant to antifungal azoles and recognized an agent invasive aspergillosis among immunocompromised hosts.
We present the draft genome sequences of two clinical strains Aspergillus turcosus, one azole-susceptible (strain HMR-AF-23/LSPQ-01275) and other azole-resistant HMR-AF-1038/LSPQ-01280), isolated from bronchoalveolar lavage fluid adult patients. These are first reported isolates A. turcosus.
Erythema nodosum (EN)-like lesions are a rare occurrence after solid organ transplantation. Differential diagnosis includes infective panniculitis, which can be feature of progressive disseminated histoplasmosis (PDH), an uncommon but severe form affecting primarily immunocompromised hosts. We report on fatal case PDH, presented as fungal panniculitis masquerading EN in renal allograft recipient 25 years discuss the clinical, histopathological, and microbiological characteristics this...
Chronic Q fever (or persistent focalized infection) is an infection caused by Coxiella burnetii, and patients can present with multisystemic manifestations including endocarditis. Membranoproliferative glomerulonephritis result from various infectious or autoimmune diseases has been described in cases of bacterial There are only a few reported which presented none them clear description membranoproliferative glomerulonephritis.
Fourier transform infrared (FTIR) spectroscopy has demonstrated applicability as a reagent-free whole-organism fingerprinting technique for both microbial identification and strain typing. For routine application of this in microbiology laboratories, acquisition FTIR spectra the attenuated total reflectance (ATR) mode simplifies workflow, providing results within minutes after initial culture without prior sample preparation.