A5030523892- Immunodeficiency and Autoimmune Disorders
- SARS-CoV-2 and COVID-19 Research
- Autoimmune and Inflammatory Disorders Research
- COVID-19 epidemiological studies
- Fungal Infections and Studies
- Vaccine Coverage and Hesitancy
- Platelet Disorders and Treatments
- Blood disorders and treatments
- Chronic Lymphocytic Leukemia Research
- Antifungal resistance and susceptibility
- Genetics and Neurodevelopmental Disorders
- Cell Adhesion Molecules Research
- COVID-19 Clinical Research Studies
- Nosocomial Infections in ICU
- Yeasts and Rust Fungi Studies
- Bacterial biofilms and quorum sensing
- Immune Response and Inflammation
- Cytokine Signaling Pathways and Interactions
- Eosinophilic Disorders and Syndromes
- Immune Cell Function and Interaction
- Genomics and Rare Diseases
- NF-κB Signaling Pathways
- Clostridium difficile and Clostridium perfringens research
- Genetic and rare skin diseases.
- Skin Diseases and Diabetes
McGill University Health Centre
2015-2022
McGill University
2021
Primary immunodeficiencies represent naturally occurring experimental models to decipher human immunobiology. We report a patient with combined immunodeficiency, marked by recurrent respiratory tract and DNA-based viral infections, hypogammaglobulinemia, panlymphopenia. He also developed moderate neutropenia but without prototypical pyogenic infections. Using whole-exome sequencing, we identified homozygous mutation in the inducible T cell costimulator ligand gene (ICOSLG; c.657C>G;...
The use of COVID-19 vaccines has been prioritised to protect the most vulnerable-notably, older people. Because fluctuations in vaccine availability, strategies such as delayed second dose and heterologous prime-boost have used. However, effectiveness these frail, people are unknown. We aimed assess antigenicity mRNA-based a real-world setting, with rationed interval dosing 16 weeks between prime boost doses.This prospective observational cohort study was done across 12 long-term care...
Summary CARD 9 deficiency ( CANDF 2; OMIM # 212050) is an autosomal‐recessive monogenic inborn error of immunity conferring susceptibility to invasive fungal diseases, including the very distinct syndrome spontaneous central nervous system candidiasis, in which opportunistic yeast genus Candida infect (either brain parenchyma and/or meninges) absence trauma, chemotherapy or underlying systemic disease. We present a patient with endophthalmitis right eye due albicans ; further investigations...
Clostridioides difficile is a major cause of health care-associated diarrhea. Severity ranges from mild to life-threatening, but this variability remains poorly understood. Microbiologic diagnosis C. infection (CDI) straightforward offers little insight into the patient's prognosis or pathophysiologic determinants clinical trajectory. The aim study was discover host-derived, CDI-specific fecal biomarkers involved in disease severity. Subjects without and with CDI diarrhea were recruited....
Background The Coronavirus disease 2019 (Covid-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has prompted accelerated vaccines development. Their use was prioritized to protect the most vulnerable, notably, elderly. Because of fluctuations in vaccine availability, strategies such as delayed second dose and heterologous prime-boost have been employed. effectiveness these frail elderly are unknown. Methods In this real-world vaccination study, under a...
Background: The Coronavirus disease 2019 (Covid-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has prompted accelerated vaccines development. Their use was prioritized to protect the most vulnerable, notably, elderly. Because of fluctuations in vaccine availability, strategies such as delayed second dose and heterologous prime-boost have been employed. effectiveness these frail elderly are unknown. Methods: In this real-world vaccination study, under a...
Ichthyosis is marked by dry, thickened, scaly skin. It may be genetic or acquired. Importantly, it a cutaneous manifestation of an underlying malignancy. Here, we present striking case paraneoplastic ichthyosis.