A5100450128- interferon and immune responses
- Immune Response and Inflammation
- Cytokine Signaling Pathways and Interactions
- NF-κB Signaling Pathways
- Animal Virus Infections Studies
- Aquaculture disease management and microbiota
- Viral Infections and Immunology Research
- T-cell and B-cell Immunology
- Viral Infections and Outbreaks Research
- Ubiquitin and proteasome pathways
- Cell death mechanisms and regulation
- Blood disorders and treatments
- Hip disorders and treatments
- Endometriosis Research and Treatment
- Amoebic Infections and Treatments
- Platelet Disorders and Treatments
- Single-cell and spatial transcriptomics
- Immunodeficiency and Autoimmune Disorders
- Influenza Virus Research Studies
- Retinopathy of Prematurity Studies
- Inflammasome and immune disorders
- Phagocytosis and Immune Regulation
- Osteoarthritis Treatment and Mechanisms
- Uterine Myomas and Treatments
- Retinal Development and Disorders
Children's Hospital of Chongqing Medical University
2018-2023
Chongqing Medical University
2018-2023
Jiangxi Normal University
2023
Ocean University of China
2019-2022
Nanjing University
2019-2020
Nanjing General Hospital of Nanjing Military Command
2020
Nanjing Drum Tower Hospital
2020
Nanjing Medical University
2020
Jiangxi Agricultural University
2019
Montreal Clinical Research Institute
2018
Abstract Intestinal ischemia reperfusion (I/R) injury is the important pathogenesis for acute intestinal barrier disruption. The STING signaling associated with gut homeostasis and integrity. However, biological function regulation of in I/R are not yet fully understood. As ligand signaling, mitochondrial DNA (mtDNA) has been found to be necroptosis. It still remains unknown whether mtDNA-STING triggers necroptosis injury. We that circulating RIPK3 was significantly increased had a positive...
Primary immunodeficiencies represent naturally occurring experimental models to decipher human immunobiology. We report a patient with combined immunodeficiency, marked by recurrent respiratory tract and DNA-based viral infections, hypogammaglobulinemia, panlymphopenia. He also developed moderate neutropenia but without prototypical pyogenic infections. Using whole-exome sequencing, we identified homozygous mutation in the inducible T cell costimulator ligand gene (ICOSLG; c.657C>G;...
Porcine deltacoronavirus (PDCoV) is an emerging swine enteropathogenic coronavirus that causes watery diarrhea, vomiting and mortality in newborn piglets. Previous studies have suggested PDCoV infection antagonizes RIG-I-like receptor (RLR)-mediated IFN-β production to evade host innate immune defense, PDCoV-encoded nonstructural protein nsp5 accessory NS6 are associated with this process. However, whether the structural protein(s) of also antagonize remains unclear. In study, we found...
Nmi is an interferon (IFN)-inducible protein homologous to IFN-inducible IFP 35. The homology consists of a novel Nmi/IFP 35 domain (NID) 90–92 amino acids that repeated in tandem each and mediates Nmi-Nmi interactions subcellular localization. In yeast two-hybrid screen with fragment containing both NIDs, we identified interaction between Deletion derivatives the proteins indicate NIDs are required for mammalian cells, co-immunoprecipitate co-localize large cytoplasmic speckles. associate...
Abstract The underlying mechanisms that determine gene expression and chromatin accessibility in retinogenesis are poorly understood. Herein, single‐cell RNA sequencing assay for transposase‐accessible performed on human embryonic eye samples obtained 9–26 weeks after conception to explore the heterogeneity of retinal progenitor cells (RPCs) neurogenic RPCs. differentiation trajectory from RPCs 7 major types verified. Subsequently, diverse lineage‐determining transcription factors identified...
Nmi was initially identified through a yeast two-hybrid interaction with N-Myc but it also interacts cMyc, Max, Fos, and several other transcription factors, including signal transducer activator of (Stat) proteins. is an interferon (IFN)-inducible protein 25% amino acid identity to the IFN-inducible IFP 35. We have found that this homology consists novel domain approximately 90-92 acids (aa) repeated in tandem each protein. This region, termed Nmi/IFP 35 (NID), important for subcellular...
Developmental dysplasia of the hip (DDH) is one most common congenital disorders in childhood. Its diverse pathological changes require different treatments and result outcomes. Although many studies have been conducted on DDH, some special pathology still unrecognized. We here presented a rare case one-year eleven-month old girl with DDH; half-free intra-articular osteocartilaginous tissue was found her right joint. X-ray, computer assisted tomography (CT) magnetic resonance imaging (MRI)...
Pseudoachondroplasia (PSACH) is a relatively common skeletal dysplasia characterized by disproportionate short stature, joint laxity, early-onset osteoarthrosis, and of the spine, epiphysis, metaphysis. It known as an autosomal dominant disease which results exclusively from mutations in gene for Cartilage Oligomeric Matrix Protein (COMP). We have identified five year old Chinese boy who was diagnosed pseudoachondroplasia according to clinical manifestations X-ray symptoms. His mother seems...
Many mammals develop specific immune responses owing to the changes in their ecological niche and diet that are essential for animal survival. However, pattern recognition receptors (PRRs) serve as first line of defense innate immunity generate host. evolutionary impacts on PRR genes Carnivora not well studied. Herein, we explored evolution 946 gene sequences 43 species elucidate molecular mechanisms carnivore adaptation complex habitats. We found PRRs were relatively conserved, different...
Gut integrity is compromised in abdominal sepsis with increased cellular apoptosis and altered barrier permeability. Intestinal epithelial cells (IEC) form a physiochemical that separates the intestinal lumen from host's internal milieu strongly involved mucosal inflammatory response immune response. Recent research indicates involvement of stimulator interferons genes (STING) pathway uncontrolled inflammation gut We investigated role STING signaling function using biopsies human patients an...
Abstract Background: Studies have shown that human interferon inducible transmembrane proteins (IFITM) family broad-spectrum antiviral capabilities. Preliminary studies in our laboratory preliminarily proved IFITMs the effect of inhibiting influenza viruses. In order to further study its mechanism and role occurrence development influenza, relevant been carried out. Methods: Fluorescence quantitative polymerase chain reaction (PCR) detection, yeast two-hybrid test optical confocal microscopy...
Background: Intestinal ischemia reperfusion (I/R) injury is the important pathogenesis for acute intestinal barrier disruption. The STING signaling associated with gut homeostasis and integrity. However, biological function regulation of in I/R are not yet fully understood. As ligand signaling, mitochondrial DNA (mtDNA) has been found to be necroptosis. It still remains unknown whether mtDNA-STING triggers necroptosis injury.Methods: levels circulating receptor interacting protein kinase 3...