A5052348906- Hematopoietic Stem Cell Transplantation
- Cardiac Arrhythmias and Treatments
- Immune Cell Function and Interaction
- Chronic Myeloid Leukemia Treatments
- Atrial Fibrillation Management and Outcomes
- Acute Myeloid Leukemia Research
- CAR-T cell therapy research
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Mesenchymal stem cell research
- Multiple Myeloma Research and Treatments
- Chronic Lymphocytic Leukemia Research
- Acute Lymphoblastic Leukemia research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cardiac Imaging and Diagnostics
- Lymphoma Diagnosis and Treatment
- Photodynamic Therapy Research Studies
- Cytomegalovirus and herpesvirus research
- Renal Transplantation Outcomes and Treatments
- Corneal Surgery and Treatments
- Polyomavirus and related diseases
- Tissue Engineering and Regenerative Medicine
- Transplantation: Methods and Outcomes
Hôpital Maisonneuve-Rosemont
2016-2025
Université de Montréal
2016-2025
Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal
2016-2025
Centre intégré universitaire de santé et de services sociaux de l'Est-de-l'Île-de-Montréal
2020-2025
Montreal Heart Institute
2011-2024
Institute of Post Graduate Medical Education and Research
2024
BioInVision (United States)
2017
Rowan University
2015
University Health Network
2014
Kiadis Pharma (Netherlands)
2014
Background —Patients surviving ventricular fibrillation (VF) or sustained tachycardia (VT) are at a high risk of death due to recurrence arrhythmia. The implantable cardioverter defibrillator (ICD) terminates VT VF, but it is not known whether this device prolongs life in these patients compared with medical therapy amiodarone. Methods and Results —A total 659 resuscitated VF unmonitored syncope were randomly assigned treatment the ICD primary outcome measure was all-cause mortality,...
The restoration and maintenance of sinus rhythm is a desirable goal in patients with atrial fibrillation, because the prevention recurrences can improve cardiac function relieve symptoms. Uncontrolled studies have suggested that amiodarone low doses may be more effective safer than other agents preventing recurrence, but this agent has not been tested large, randomized trial.
Amiodarone is effective in maintaining sinus rhythm atrial fibrillation but associated with potentially serious toxic effects. Dronedarone a new antiarrhythmic agent pharmacologically related to amiodarone developed reduce the risk of side effects.In two identical multicenter, double-blind, randomized trials, one conducted Europe (ClinicalTrials.gov number, NCT00259428 [ClinicalTrials.gov] ) and United States, Canada, Australia, South Africa, Argentina (termed non-European trial, NCT00259376...
Blast crisis chronic myelogenous leukemia (CML-BC) and Philadelphia chromosome–positive (Ph1-positive) acute lymphocytic (ALL) are 2 fatal BCR/ABL-driven leukemias against which Abl kinase inhibitors fail to induce a long-term response. We recently reported that functional loss of protein phosphatase 2A (PP2A) activity is important for CML blastic transformation. assessed the therapeutic potential PP2A activator FTY720 (2-amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol hydrochloride), an...
Several lines of evidence indicate that immunologic effectors, particularly suppressor T cells and NK cells, may play a role in the pathogenesis idiopathic repetitive abortions. To investigate involvement these immune cell populations, we determined immunophenotypic characteristics endometrial leukocytes from nonpregnant recurrent aborters. Habitual aborters with negative investigation underwent an biopsy during their secretory phase were followed prospectively to assess clinical outcome....
Depression predicts prognosis in many cardiac conditions, including congestive heart failure (CHF). Despite heightened risk patients with comorbid atrial fibrillation (AF) and CHF, depression has not been studied this group. This substudy, from the AF-CHF Trial of rate- versus rhythm-control strategies, investigated whether long-term cardiovascular mortality left ventricular ejection fraction <or=35%, CHF symptoms, AF history who receive optimal medical care.Depression symptoms (Beck...
Background— Atrial fibrillation (AF) is commonly associated with impaired quality of life. There no simple validated scale to quantify the functional illness burden AF. The Canadian Cardiovascular Society Severity in Fibrillation (CCS-SAF) a bedside that ranges from class 0 4, effect on life severe quality. This study was performed validate scale. Methods and Results— In 484 patients documented AF (62.2�12.5 years age, 67% men; 62% paroxysmal 38% persistent/permanent), SAF assessed 2...
Abstract Among bone marrow cells, hematopoietic and mesenchymal components can contribute to repair damaged organs. Such cells are usually used in acute diseases but few options available for the treatment of chronic disorders. In this study, we have a laser-induced model open angle glaucoma (OAG) evaluate potential cell populations mechanisms involved tissue repair. addition, investigated remodeling as method targeting effector into tissues. We demonstrate that among stem (MSC) induce...
The prognostic significance of programmed ventricular stimulation and its usefulness in relation to other forms invasive noninvasive testing was evaluated 150 survivors acute myocardial infarction. Ventricular tachyarrhythmias 6 beats or more were induced 35 (23%) patients. No significant differences existed between patients with inducible those without tachycardia respect occurrence spontaneous arrhythmias the early recovery phase infarction predischarge exercise-induced ischemia...
The long-term prognosis of variant angina and the factors influencing it were assessed in 217 consecutive patients hospitalized our coronary care unit followed for a mean 65 months (range 2 to 123). Cardiac death occurred 30 an additional 54 experienced nonfatal myocardial infarction. Survival at 1 5 years was 95% 89%, respectively; survival without infarction 83% 69%. Coronary disease degree activity strong predictors by Cox analysis. year 99%, that 94%, respectively, with one-vessel (n =...