A5015187893- Acute Myeloid Leukemia Research
- Legal and Constitutional Studies
- Legal Systems and Judicial Processes
- Chronic Myeloid Leukemia Treatments
- Law, Economics, and Judicial Systems
- Judicial and Constitutional Studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Protein Degradation and Inhibitors
- Multiple Myeloma Research and Treatments
- Law, Rights, and Freedoms
- Histone Deacetylase Inhibitors Research
- Cancer Genomics and Diagnostics
- Nuclear Structure and Function
- Cancer-related molecular mechanisms research
- Acute Lymphoblastic Leukemia research
- International Arbitration and Investment Law
- MicroRNA in disease regulation
- American Constitutional Law and Politics
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- Immune Cell Function and Interaction
- Glioma Diagnosis and Treatment
- Endometrial and Cervical Cancer Treatments
- Sarcoma Diagnosis and Treatment
- Genetic factors in colorectal cancer
Tallaght University Hospital
2025
Emory University
2025
The Ohio State University
2015-2024
Karyopharm Therapeutics (United States)
2020-2024
Columbia University
2023-2024
Sandia National Laboratories
2024
University of Michigan–Ann Arbor
1992-2023
Ohio University
2011-2023
The University of Texas MD Anderson Cancer Center
2023
State Street (United States)
2023
Stenting of native coronary arteries with a balloon-expandable stent was attempted in 226 patients after elective angioplasty. Delivery the device successful 213 (94%) patients. Of these, 39 received aspirin and dipyridamole only (group 1) 174 aspirin, dipyridamole, warfarin for 1-3 months 2). There no abrupt closure (less than or equal to 1 day) perioperative death either group. In-hospital complications group compared 2 were as follows: subacute (1-14 days), seven (18%) versus one (0.6%)...
The success of tyrosine kinase inhibitors (TKIs) in treating chronic myeloid leukemia (CML) depends on the requirement for BCR-ABL1 activity CML progenitors. However, quiescent HSCs are TKI resistant and represent a kinase-independent disease reservoir. Here we have shown that persistence leukemic BM requires inhibition tumor suppressor protein phosphatase 2A (PP2A) expression--but not activity--of oncogene. Examination from patients healthy individuals revealed PP2A was suppressed compared...
Dorsal root ganglia (DRG) somatosensory neurons detect mechanical, thermal, and chemical stimuli acting on the body. Achieving a holistic view of how different DRG neuron subtypes relay neural signals from periphery to CNS has been challenging with existing tools. Here, we develop curate mouse genetic toolkit that allows for interrogating properties functions distinct cutaneous targeting subtypes. These tools have enabled broad morphological analysis, which revealed axon arborization areas...
BACKGROUND Several metallic intracoronary stents are currently undergoing preliminary evaluation to ascertain potential benefit as means reduce the 30-40% incidence of restenosis after balloon angioplasty. METHODS AND RESULTS To determine and correlates placement Palmaz-Schatz in native coronary arteries first group patients selected for this procedure, clinical quantitative angiographic data from 206 consecutive (221 stenoses) with successful stent (diameter stenosis < 50%) were...
Long non-coding RNAs (lncRNAs) are important regulatory molecules that implicated in cellular physiology and pathology. In this work, we dissect the functional role of HOXB-AS3 lncRNA patients with NPM1-mutated (NPM1mut) acute myeloid leukemia (AML). We show regulates proliferative capacity NPM1mut AML blasts vitro vivo. is shown to interact ErbB3-binding protein 1 (EBP1) guide EBP1 ribosomal DNA locus. Via mechanism, RNA transcription de novo synthesis. propose context NPM1 mutations,...
Balanced rearrangements involving the KMT2A gene, located at 11q23, are among most frequent chromosome aberrations in acute myeloid leukemia (AML). Because of numerous fusion partners, mutational landscape and prognostic impact specific 11q23/KMT2A not fully understood. We analyzed clinical features 172 adults with AML recurrent rearrangements, 141 whom had outcome data available. compared outcomes these patients 1,097 without an rearrangement categorized according to 2017 European...
Summary Mechanical and thermal stimuli acting on the skin are detected by morphologically physiologically distinct sensory neurons of dorsal root ganglia (DRG). Achieving a holistic view how this diverse neuronal population relays information from to central nervous system (CNS) has been challenging with existing tools. Here, we used transcriptomic datasets mouse DRG guide development curation genetic toolkit interrogate transcriptionally defined neuron subtypes. Morphological analysis...
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To date, limited evidence is available specifically evaluating ridge preservation (RP) and implant placement in molar sites. The primary aim of this study to radiographically compare alveolar changes with without RP cone-beam computed tomography (CBCT).This parallel, two-arm randomized clinical trial included 40 patients evenly distributed between two treatment groups. After extraction, sites were allowed heal naturally or received freeze-dried bone allograft covered by a non-resorbable...
Clinical outcome of patients with acute myeloid leukemia (AML) is associated cytogenetic and molecular factors patient demographics (e.g., age race). We compared survival 25,523 non-Hispanic Black White adults AML using Surveillance Epidemiology End Results (SEER) Program data performed mutational profiling 1,339 treated on frontline Alliance for Trials in Oncology (Alliance) protocols. had shorter than patients, both SEER the setting clinical trials. The disparity was especially pronounced...
Abstract Purpose: Selinexor is an oral selective inhibitor of exportin-1 (XPO1) with efficacy in various solid and hematologic tumors. We assessed intratumoral penetration, safety, selinexor monotherapy for recurrent glioblastoma. Patients Methods: Seventy-six adults Karnofsky Performance Status ≥ 60 were enrolled. undergoing cytoreductive surgery received up to three doses (twice weekly) preoperatively (Arm A; n = 8 patients). not 50 mg/m2 B, 24), or mg C, 14) twice weekly, 80 once weekly...
The novel coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome 2 (SARS-CoV-2) is responsible for recent global pandemic. nuclear export protein (XPO1) has a direct role in of SARS-CoV proteins including ORF3b, ORF9b, and nucleocapsid. Inhibition XPO1 induces anti-inflammatory, anti-viral, antioxidant pathways. Selinexor an FDA-approved inhibitor. Through bioinformatics analysis, we predicted sequences ACE-2 confirmed vitro testing that inhibition with selinexor...
Antitumor activity in preclinical models and a phase I study of patients with dedifferentiated liposarcoma (DD-LPS) was observed selinexor. We evaluated the clinical benefit selinexor previously treated DD-LPS whose sarcoma progressed on approved agents.
IL-5, which is produced mainly by activated T cells and allergically triggered mast cells, a major survival differentiation factor for eosinophils, therefore, of relevance to diseases associated with this type cell infiltration, most importantly asthma. In study, we have examined the transcriptional regulation human IL-5 in mouse line, CPII, stimulated IgE Ag. We report that an inducible activity region between -177 -80, constitutive -80 -70, promoter gene, are both necessary activation. A...