A5002061358- Hematopoietic Stem Cell Transplantation
- Multiple Myeloma Research and Treatments
- Acute Lymphoblastic Leukemia research
- Chronic Lymphocytic Leukemia Research
- Acute Myeloid Leukemia Research
- Immune Cell Function and Interaction
- Cancer Treatment and Pharmacology
- Lymphoma Diagnosis and Treatment
- Mesenchymal stem cell research
- Polyomavirus and related diseases
- Neuroendocrine regulation and behavior
- Renal Transplantation Outcomes and Treatments
- T-cell and B-cell Immunology
- Chronic Myeloid Leukemia Treatments
- Receptor Mechanisms and Signaling
- Protein Degradation and Inhibitors
- CAR-T cell therapy research
- Chemical Synthesis and Analysis
- Transplantation: Methods and Outcomes
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Cytomegalovirus and herpesvirus research
- Neuropeptides and Animal Physiology
- Viral-associated cancers and disorders
- Neutropenia and Cancer Infections
Hôpital Maisonneuve-Rosemont
2016-2025
Université de Montréal
2016-2025
Amgen (Switzerland)
2024
Université de Lille
2024
Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal
2016-2023
Goethe University Frankfurt
2017
Medical University of Warsaw
2017
University of Ottawa
2010
Institute for Research in Immunology and Cancer
2009
Clinical Research Management
2007
Many cancer patients take antioxidant vitamin supplements with the hope of improving outcome conventional therapies and reducing adverse effects these treatments. A randomized trial was conducted to determine whether supplementation vitamins could reduce occurrence severity acute radiation therapy improve quality life without compromising treatment efficacy.We a randomized, double-blind, placebo-controlled among 540 head neck treated therapy. Patients were randomly assigned into two arms....
Background: Although low dietary intakes of antioxidant vitamins and minerals have been associated with higher risks cancer, results trials testing supplementation for cancer chemoprevention equivocal. We assessed whether could reduce the incidence second primary cancers among patients head neck cancer. Methods: conducted a multicenter, double-blind, placebo-controlled, randomized trial 540 stage I or II treated by radiation therapy between October 1, 1994, June 6, 2000. Supplementation...
The primary objectives of this study were 1) to determine the functional relationship between microvascular blood flow (Q) and arteriolar internal diameter (D) 2) whether conformed a theoretical optimality prediction--that is proportional cube (Q = kD3). Paired velocity measurements in cremaster muscle microvasculature eight normotensive (WKY) hypertensive (SHR) rats made under control conditions following maximal dilation with topically applied adenosine. A total 160 paired flow-diameter...
PURPOSE The lack of accurate criteria to predict the response radiotherapy for individual patients with squamous cell carcinoma head and neck (HN-SCC) remains a major problem. purpose this study was investigate role several biologic tumor markers complement clinical prognostic factors in assessment SCCs. PATIENTS AND METHODS p53, ki-67, c-erb B-2, heat-shock protein-27 (HSP-27), glutathione S transferase (GSTpi) were evaluated by immunohistochemistry on biopsies from 101 treated cancer...
The compound [3H]Tyr1,D-Ala2,Leu-OH5]enkephalin has been synthesised as a potentially selective substrate for enkephalin dipeptidyl carboxypeptidase (enkephalinase) activity in brain. Incubations the presence of homogenates and particulate fractions from rodent human brain result formation [3H]Tyr-D-Ala-Gly, which can be conveniently isolated by polystyrene bead column chromatography. enzyme responsible hydrolysis Gly3-Phe4 amide bond this displays close resemblance to that hydrolysing...
High-dose chemotherapy with autologous stem cell transplantation (ASCT) remains the standard of care for patients multiple myeloma. Outpatient ASCT can be an attractive option given wait times and costs associated inpatient procedures. We initiated outpatient protocol in 2006. Patients were treated at a university hospital clinic that was open 5 days week. The present study investigated safety cost-effectiveness program. Ninety-one underwent between 2006 2010. majority (77%) had Durie-Salmon...
Graft-versus-host disease in the upper gastrointestinal tract presents with anorexia, vomiting, and abdominal discomfort. Because these symptoms are not specific, we have proposed that a diagnosis of GI GVHD requires histologic confirmation. However, utility endoscopy has been examined. We report retrospective analysis 77 allogeneic bone marrow transplantation recipients who received simultaneous lower biopsies. Upper was found 44% patients, whom 59% also had positive biopsy (P <0.001)....
Cord blood (CB) transplantation is hampered by low cell dose and high nonrelapse mortality (NRM). A phase 1-2 trial of UM171-expanded CB transplants demonstrated safety favorable preliminary efficacy. The aim the current analysis was to retrospectively compare results with those after unmanipulated matched-unrelated donor (MUD) transplants. Data from recipients MUD were obtained Center for International Blood Marrow Transplant Research (CIBMTR) database. Patients directly matched number...
Objective: Umbilical cord blood (UCB) represents a valuable graft source in the absence of human leukocyte antigen (HLA)-matched donor for hematopoietic cell transplantation (HCT). Donor-specific anti-HLA antibodies (DSAs), targeting grafts with mismatched HLA antigens, pose significant obstacle by increasing risk primary failure, delayed engraftment, and decreased survival. Existing literature on desensitization has primarily focused haploidentical transplants, there is lack experience...
Abstract Background Cold agglutinin disease (CAD) or syndrome (CAS) can be particularly challenging when autologous stem cell transplant (ASCT) is needed. Standard peripheral blood (PBSC) collection and manipulation involve ex vivo manipulations at lower than body temperature, predisposing to agglutination during graft collection, handling, processing, infusion. Study Design Methods We describe the first case of ASCT for relapsing lymphoma in a patient with high‐titer CAD requiring...