A5102724199- Head and Neck Cancer Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Tracheal and airway disorders
- Head and Neck Surgical Oncology
- Ear and Head Tumors
- Reconstructive Surgery and Microvascular Techniques
- Organ and Tissue Transplantation Research
- Cancer Cells and Metastasis
- Cancer Diagnosis and Treatment
- Voice and Speech Disorders
- Metastasis and carcinoma case studies
- Cleft Lip and Palate Research
- Transplantation: Methods and Outcomes
- Airway Management and Intubation Techniques
- Sarcoma Diagnosis and Treatment
- Colorectal and Anal Carcinomas
- COVID-19 and healthcare impacts
- RNA modifications and cancer
- Pancreatic and Hepatic Oncology Research
- Genetic factors in colorectal cancer
- Tumors and Oncological Cases
- Cancer-related Molecular Pathways
- Cancer Genomics and Diagnostics
- Peripheral Nerve Disorders
- Oral health in cancer treatment
Hôpital de la Croix-Rousse
2017-2025
Université Claude Bernard Lyon 1
2017-2025
Hospices Civils de Lyon
2017-2025
Centre National de la Recherche Scientifique
2022
Hôpital Lyon Sud
2018-2021
Centre Hospitalier de l’Université de Montréal
2019
Hôpital Nord
2017-2018
Oropharyngeal squamous cell carcinomas (OPSCC) related to human papillomavirus (HPV) infection have a better prognosis than those without HPV infection. Although p16INK4a overexpression is used as surrogate marker for infection, 5-20% of p16-positive OPSCC are described being unrelated with worse overall survival compared OPSCC-related HPV. There therefore risk undertreating proportion patients falsely considered be HPV-driven because p16 positivity. TP53 mutations highly prevalent in driven...
Abstract Purpose Sensory alterations and oral manifestations are prevalent among head neck cancer (HNC) patients. While taste smell have been thoroughly investigated, studies on their somatosensory perception remain limited. Building upon our previous publication that primarily focused objective measurements, the present work examined self-reported sensory perception, including somatosensation symptoms, in HNC patients evaluated link with eating behaviour. Methods A cross-sectional study was...
Background In the case of a locoregional recurrence oropharyngeal squamous cell carcinoma, curative standard care is surgery. Our main purpose this study was to determine preoperative prognostic factors that would allow us select patients on whom we could expect good results with salvage Methods We conducted monocentric retrospective from 2005 2013. It included all treated for carcinoma Their initial treatment radiotherapy. Results Fifty-two were included. Poor survival cT status (P = .0039)...
Genetic factors behind the increasing incidence of human papillomavirus (HPV) negative head and neck squamous cell carcinoma (HNSCC) in young non-smokers are suspected, but have not been identified. Recently, rs6942067, a single nucleotide polymorphism (SNP) located upstream DCBLD1 gene, was found associated with non-smoking lung adenocarcinoma. To validate if this SNP is also implicated HNSCC, participants The Cancer Genome Atlas HNSCC cohort were investigated for rs6942067 status,...
Oncocytic adenocarcinoma (OC) of the salivary glands is a rare and controversial entity. It was recently reclassified as "salivary carcinoma NOS emerging entities" in 2022 WHO classification head neck tumors. The lack specific molecular alterations its potential affiliation with other gland carcinomas, such oncocytic mucoepidermoid carcinomas (OMEC) or subtype duct (OSDC) justified this reclassification. becoming essential to clarify complex spectrum diagnoses surrounding objective study...
Aims Poorly differentiated neuroendocrine carcinoma (PDNEC) of the head and neck is a rare high‐grade neoplasm. Human papillomavirus (HPV) status p16 are as yet unclear among PDNECs, owing to lack statistical analysis. The objective present study was therefore evaluate their potential clinicopathological associations, prognostic impact on overall survival in PDNECs neck, regardless HPV genotype. Methods results All cases PDNEC between 1998 2019 were identified from database Lyon university...
Squamous cell carcinoma is the most common type of head and neck cancer (HNSCC) with a disease-free survival at 3 years that does not exceed 30%. Biomarkers able to predict clinical outcomes are clearly needed. The purpose this study was investigate whether short-term culture tumour fragments irradiated ex vivo could anticipate patient responses chemo- and/or radiotherapies. Biopsies were collected prior treatment from cohort 28 patients non-operable tumours oral cavity or oropharynx, then...
Patients with locally advanced oropharyngeal carcinoma treated neoadjuvant chemotherapy are reassessed both radiologically and clinically to adapt their treatment after the first cycle. However, some responders show early tumor progression adjuvant radiotherapy. This cohort study evaluated circulating cells (CTCs) from a population of patients docetaxel, cisplatin, 5-fluorouracil (DCF) induction or DCF modified dose fractioned administration. The counts phenotypes CTCs were assessed at...
The base of the tongue (BOT) is second most common site for squamous cell carcinoma (SCC) in oropharynx. There are currently no clear guidelines management BOT SCC. Our main objective was to compare oncological outcomes two minimally invasive approaches, transoral laser microsurgery (TLM) and robot-assisted surgery (TORS). This a retrospective French GETTEC (Groupe d’Études des Tumeurs de la Tête et du Cou) multicenter study patients with SCC removed surgically either by TLM or TORS between...