A5086840014- Sepsis Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Intensive Care Unit Cognitive Disorders
- Respiratory Support and Mechanisms
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Long-Term Effects of COVID-19
- Family and Patient Care in Intensive Care Units
- Nosocomial Infections in ICU
- Cardiac Arrest and Resuscitation
- Disaster Response and Management
- SARS-CoV-2 and COVID-19 Research
- Cardiac, Anesthesia and Surgical Outcomes
- Thermal Regulation in Medicine
- Anesthesia and Sedative Agents
- Surgical site infection prevention
- Hospital Admissions and Outcomes
- Renal Transplantation Outcomes and Treatments
- Global Health Workforce Issues
- Cardiac pacing and defibrillation studies
- Climate Change and Health Impacts
- COVID-19 and healthcare impacts
- Antibiotic Resistance in Bacteria
- Heart Failure Treatment and Management
Université Claude Bernard Lyon 1
2020-2025
Hospices Civils de Lyon
2020-2025
bioMérieux (France)
2025
Hôpital de la Croix-Rousse
2021-2025
Hôpital Edouard Herriot
2024
Infections are a leading cause of early mortality after liver transplantation (LT). Prior to transplantation, cirrhosis-associated immune dysfunction significantly increases the risk infection. This study investigated potential monitoring, with focus on monocytic HLA-DR (mHLA-DR) expression, as predictor post-LT complications. We conducted prospective 130 patients awaiting LT at Lyon University Hospital assess mHLA-DR lymphocyte subsets, and T-cell function before LT. Multivariate analysis...
Background: Cholestasis commonly occurs after orthotopic liver transplantation. It can be extrahepatic because of mechanical obstruction or intrahepatic various causes. During cholestasis episodes, blood concentrations tacrolimus (TAC) metabolites may increase, potentially affecting TAC measured by immunoassays. This study aimed to simultaneously evaluate the analytical performance 2 immunoassays, a quantitative microsphere system (QMS) immunoassay, and chemiluminescence microparticle using...
Abstract Background A 10-day dexamethasone regimen has emerged as the internationally adopted standard-of-care for severe COVID-19 patients. However, immune response triggered by SARS-CoV-2 infection remains a complex and dynamic phenomenon, leading to various profiles trajectories. The status of patients following complete treatment yet be thoroughly documented. Results To analyze monocyte HLA-DR expression (mHLA-DR) CD4 + T lymphocyte count (CD4) in critically ill after course evaluate...
The recent SarsCov2 pandemic has disrupted healthcare system notably impacting intensive care units (ICU). In severe cases, the immune is dysregulated, associating signs of hyperinflammation and immunosuppression. present work, we investigated, using a joint modeling approach, whether trajectories cellular immunological parameters were associated with survival COVID-19 ICU patients. This study based on REA-IMMUNO-COVID cohort including 538 patients admitted to between March 2020 May 2022....
Liver graft-recipient matching remains challenging, and both morphologic hemodynamic characteristics have been shown to be relevant indicators of post-transplant outcomes. However, no combined analysis is available date. To study the impact liver grafts on transplantation outcomes, we retrospectively evaluated all consecutive 257 transplantations with prospective measurements from 2017 2020 in a single-center perspective. First, compared recipients or without large-for-size (LFS), defined by...
Immune responses affiliated with COVID-19 severity have been characterized and associated deleterious outcomes. These approaches were mainly based on research tools not usable in routine clinical practice at the bedside. We observed that a multiplex transcriptomic panel prototype termed Profiling Panel (IPP) could capture dysregulation of immune ICU patients admission. Nine transcripts mortality univariate analysis this 9-mRNA signature remained significantly multivariate included age, SOFA...
Liver transplantation (LT) is a technically demanding surgical procedure associated with substantial postoperative morbidity. Several specialties have found benefits in performing sequential 2-team surgery, one surgeon the resection and another reconstruction.1,2 We applied this strategy for our LT program to facilitate young transplant surgeons' training decrease fatigue of teams. present here effects versus single-team on patient outcomes. defined "2-team" as which performed hepatectomy...
<title>Abstract</title> <bold>Background</bold> Infections are a leading cause of early mortality after liver transplantation (LT). Prior to transplantation, cirrhosis-associated immune dysfunction significantly increases the risk infection. This study investigated potential monitoring, with focus on monocytic HLA-DR (mHLA-DR) expression, as predictor post-LT complications.<bold>Methods</bold> We conducted prospective 130 patients awaiting LT at Lyon University Hospital assess mHLA-DR...
Background: Advanced stages of cirrhosis are characterized by the occurrence progressive immune alterations known as CAID (Cirrhosis Associated Immune Dysfunction). In advanced cirrhosis, liver transplantation (LT) remains only curative treatment. Sepsis, shares many similarities with decompensated in terms immuno-inflammatory response. both conditions, neutrophil-lymphocyte ratio (NLR) is associated poor outcomes. Based on sepsis, we hypothesized that could observe cirrhotic and LT patients...